Surgical Clinics of North America, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 134 - 134
Published: Jan. 8, 2025
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies head and neck (HNSCC). HNSCC recognized as eighth commonly occurring cancer globally in men. It essential to distinguish between cancers arising regions due significant differences their etiologies, treatment approaches, prognoses. As Cancer Genome Atlas (TCGA) dataset available HNSCC, survival analysis prognosis OSCC patients based on TCGA for discovering gene expression-based prognostic biomarkers limited. To address this paucity, we aimed provide comprehensive evidence by recruiting studies that have reported new biomarkers/signatures establish a model predict patients. Using PubMed search, identified 34 been using least absolute shrinkage selection operator (LASSO)-based Cox regression analyses signature related different pathways from past 4 years. Our review was focused summarizing these signatures implications targeted therapy FDA-approved drugs. Furthermore, conducted an LASSO signatures. findings revealed 13 correlated greater number regulatory T cells (Tregs) protective with increased recurrence-free overall rates. Conversely, two displayed opposing trend cases OSCC. We will also explore how dysregulation impacts immune status, promoting tumor evasion or, conversely, enhancing surveillance. Overall, insight future anti-cancer therapies potential associated poor
Language: Английский
Citations
0
Pathology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0
Russian Journal of Biotherapy, Journal Year: 2024, Volume and Issue: 23(4), P. 22 - 29
Published: Dec. 19, 2024
Background. Skin melanoma (SM) is a malignant non-epithelial tumor of transformed melanocytes with predominant localization on the skin (more than 90 % cases). According to statistics for 2021, SM in Russia accounted 1.82 all neoplasms adult population and 12.65 tumors. There has been steady annual increase incidence throughout world, especially countries predominantly Caucasian population. In Russia, over past 10 years, mortality from increased by 17.6 %. heterogeneous high metastatic potential, because addition standard clinical pathomorphological prognostic factors, identification additional factors progression unfavorable prognosis disease remains an urgent unresolved problem modern oncology. Aim . To determine role spontaneous regression occurrence based analysis literature data their systematization. Results. This review reflects various global research progression. Spontaneous immunological process which disappearance cells observed, leads division into separate islands intermediate areas non-tumor tissue. The mechanism primary SM, as well its significance, not understood studied. Of course, most researchers primarily associate immune response, since lymphocytic infiltration was noted cases regression. presence lymphoid infiltration, quantitative qualitative ratio cells, are important development process, affect effectiveness immunotherapy greater extent factor favorable prognosis. Conclusion still controversial issue. Interestingly, number studies demonstrate that independent predictor SM.
Language: Английский
Citations
0
Surgical Clinics of North America, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0