Exosome-derived miR-1290 in blood as a predictive biomarker for occult neck metastasis in patients with cT1-2N0 tongue cancer

Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Advancements in Autophagy Modulation for the Management of Oral Disease: A Focus on Drug Targets and Therapeutics

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2645 - 2645

Published: Nov. 19, 2024

Autophagy is an intrinsic breakdown system that recycles organelles and macromolecules, which influences metabolic pathways, differentiation, thereby cell survival. Oral health essential component of integrated well-being, it critical for developing therapeutic interventions to understand the molecular mechanisms underlying maintenance oral homeostasis. However, because complex dynamic relationship between autophagy health, associated treatment modalities have not yet been well elucidated. Determining how affects at level may enhance understanding prevention targeted diseases. At level, hard soft tissues develop interactions epithelial mesenchymal cells. Aging contributes progression various disorders including periodontitis, cancer, periapical lesions during aging. levels decrease with age, thus indicating a possible association In this review, we critically review aspects their significance in context diseases lesions, periodontal conditions, candidiasis. A better its can guide us new preventative strategies management

Language: Английский

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Role of UFMylation in tumorigenesis and cancer immunotherapy

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 23, 2024

Protein post-translational modifications (PTMs) represent a crucial aspect of cellular regulation, occurring after protein synthesis from mRNA. These modifications, which include phosphorylation, ubiquitination, acetylation, methylation, glycosylation, Sumoylation, and palmitoylation, play pivotal roles in modulating function. PTMs influence localization, stability, interactions, thereby orchestrating variety processes response to internal external stimuli. Dysregulation is linked spectrum diseases, such as cancer, inflammatory neurodegenerative disorders. UFMylation, type PTMs, has recently gained prominence for its regulatory role numerous processes, including stress, key signaling pathways influencing functions. This review highlights the function UFMylation development progression tumors, underscoring potential therapeutic target. Moreover, we discuss tumorigenesis malignant progression, explore impact on cancer immunotherapy. The article aims provide comprehensive overview biological functions propose how targeting could enhance effectiveness immunotherapy strategies.

Language: Английский

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PER2 binding to PDK1 enhances the cisplatin sensitivity of oral squamous cell carcinoma through inhibition of the AKT/mTOR pathway

Cellular Signalling, Journal Year: 2024, Volume and Issue: 122, P. 111327 - 111327

Published: July 28, 2024

Language: Английский

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