Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham-controlled pilot trial DOI Creative Commons
Milenko Kujovic,

Christian Bahr,

Mathias Riesbeck

et al.

Borderline Personality Disorder and Emotion Dysregulation, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 14, 2025

Abstract Background Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in treating borderline personality disorder (BPD). Impulsivity impaired decision-making prominent features of BPD, therapeutic interventions targeting these symptoms could lead to significant improvements. Objective/Hypothesis We hypothesized that intermittent theta burst (iTBS), a modified rTMS protocol targets the left dorsolateral prefrontal cortex, would enhance effects DBT, leading greater improvements impulsivity compared with sham stimulation. Methods performed single-blind, randomized, sham-controlled pilot study evaluate efficacy iTBS as an add-on 8-week DBT program for BPD routine inpatient setting. A total 53 patients were randomly assigned receive either ( n = 25) or 28) during weeks 4 8 36 met inclusion criteria present analysis ≥ 16 20 iTBS/sham sessions assessment delay discounting). The endpoints Barratt Impulsiveness Scale-15 Monetary Choice Questionnaire decision-making/delay discounting. Results mixed model repeated measures 2 × factorial between-subjects design showed overall improvement over time but not No differences found between sham, although post hoc tests revealed changes group (mean diff -4.7, p .001, Cohen’s d 0.68) -2.1, .077, 0.31). Conclusions may offer long-term benefits treatment suggesting need further investigation larger-scale studies. Trial registration Registered at drks.de (no. DRKS00020413) on January 13, 2020.

Language: Английский

Effects on impulsivity and delay discounting of intermittent theta burst stimulation add-on to dialectical behavioral therapy in borderline personality disorder: a randomized, sham-controlled pilot trial DOI Creative Commons
Milenko Kujovic,

Christian Bahr,

Mathias Riesbeck

et al.

Borderline Personality Disorder and Emotion Dysregulation, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 14, 2025

Abstract Background Dialectical behavioral therapy (DBT) and repetitive transcranial magnetic stimulation (rTMS) are both effective in treating borderline personality disorder (BPD). Impulsivity impaired decision-making prominent features of BPD, therapeutic interventions targeting these symptoms could lead to significant improvements. Objective/Hypothesis We hypothesized that intermittent theta burst (iTBS), a modified rTMS protocol targets the left dorsolateral prefrontal cortex, would enhance effects DBT, leading greater improvements impulsivity compared with sham stimulation. Methods performed single-blind, randomized, sham-controlled pilot study evaluate efficacy iTBS as an add-on 8-week DBT program for BPD routine inpatient setting. A total 53 patients were randomly assigned receive either ( n = 25) or 28) during weeks 4 8 36 met inclusion criteria present analysis ≥ 16 20 iTBS/sham sessions assessment delay discounting). The endpoints Barratt Impulsiveness Scale-15 Monetary Choice Questionnaire decision-making/delay discounting. Results mixed model repeated measures 2 × factorial between-subjects design showed overall improvement over time but not No differences found between sham, although post hoc tests revealed changes group (mean diff -4.7, p .001, Cohen’s d 0.68) -2.1, .077, 0.31). Conclusions may offer long-term benefits treatment suggesting need further investigation larger-scale studies. Trial registration Registered at drks.de (no. DRKS00020413) on January 13, 2020.

Language: Английский

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