Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 1822 - 1822
Published: March 8, 2025
Background: Apathy is a common neuropsychiatric symptom in all stages of dementia, significantly complicating patient management. This study examines the prevalence apathy across Alzheimer’s Disease (AD), Lewy Body Dementia (LBD), Frontotemporal (FTD), and Vascular (VD) explores its associations with cognitive functions, symptoms, magnetic resonance imaging (MRI) findings. Methods: retrospective, cross-sectional included 200 patients diagnosed AD, LBD, FTD, VD along 100 healthy controls (HCs). was assessed using Evaluation Scale. Depression anxiety were evaluated Geriatric Scale Anxiety Scale, respectively. Cognitive function measured Mini-Mental State Examination (MMSE) Addenbrooke’s Examination-Revised (ACE-R). MRI findings atrophy scales that are routinely utilized dementia assessments. Results: more prevalent MCI compared to HC. However, there no significant differences among subtypes. showed correlation depression, anxiety, or performance. Notably, analysis revealed strong association between orbitofrontal (OF) sulci atrophy. Conclusions: critical linked OF presenting challenges These emphasize importance integrating assessments clinical practice. Larger, longitudinal studies needed further clarify pathophysiology management dementia.
Language: Английский