Recent Trends and Advances in Design of Rapid Tests for Colorimetric Detection of Staphylococcus aureus DOI

Cemile Yilmaz,

Çağla Çelik, Nilay Ildi̇z

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Staphylococcus aureus (S. aureus), which is a member of Micrococcacease family, one the most dangerous disease-causing bacteria. S. also biggest factor causing hospital-acquired infections worldwide, as well life-threatening such meningitis, septicaemia, and suppurating wounds in human body. Today, there have been various phenotypic and/or genotypic methods for detection both methicillin-resistant (MRSA) strains. Although commonly used certain rapid results, they are quite expensive rarely available all hospitals; need costly complicated devices expert use. To address these issues, researchers recently developed nanomaterials (NMs) organic molecules-based rapid, sensitive, economical MRSA. We focus on evaluating colorimetric assays using NMs pH indicator-containing tests cost-effective MRSA, specifically target their application clinical environmental contexts.

Language: Английский

Genome-wide pan-GPCR cell libraries accelerate drug discovery DOI Creative Commons
Hanting Yang, Yongfu Wang, Wei Liu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(10), P. 4296 - 4311

Published: June 26, 2024

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account about 40% of FDA-approved drugs, representing the most successful targets. However, only approximately 15% 800 human targeted by market leaving numerous opportunities discovery among remaining receptors. Cell expression systems play crucial roles GPCR field, including novel target identification, structural functional characterization, potential ligand screening, signal pathway elucidation, safety evaluation. Here, we discuss principles, applications, limitations widely used cell GPCR-targeted discovery, function investigation, pharmacological property studies. We also propose three strategies constructing genome-wide pan-GPCR libraries, which will provide a powerful platform facilitate study mechanisms evaluation, ultimately accelerating process

Language: Английский

Citations

8
Antibiotic resistance, biofilm formation, and molecular epidemiology of Staphylococcus aureus in a tertiary hospital in Xiangyang, China DOI

Yi-Tong Tang,

Na Xiao, Jiu-Ming Zou

et al.

Brazilian Journal of Microbiology, Journal Year: 2024, Volume and Issue: 55(2), P. 1305 - 1315

Published: Feb. 16, 2024

Language: Английский

Citations

1
Nordalbergin Synergizes with Novel β-Lactam Antibiotics against MRSA Infection DOI Open Access
Haiting Wang,

Sangyu Hu,

Yuzhu Pei

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7704 - 7704

Published: July 14, 2024

The synergetic strategy has created tremendous advantages in drug-resistance bacterial infection treatment, whereas challenges related to novel compound discovery and identifying drug-binding targets still remain. mechanisms of antimicrobial resistance involving

Language: Английский

Citations

1
Evaluation of Arabic gum antibacterial and wound healing activities against Staphylococcus aureus isolates obtained from skin infections DOI Creative Commons

Deyaa M. Elebiary,

Hesham M. Mahdy,

Ahmed M. Mansour

et al.

Microbial Biosystems, Journal Year: 2024, Volume and Issue: 9(1), P. 129 - 138

Published: July 25, 2024

Staphylococcus aureus is a Gram-positive bacterium that has reflected noteworthy problem for public health. Nearly all strains secrete lipase enzymes, which may cause damage to host tissues and deactivate immune systems. This pathogen colonize the skin soft tissues. study aimed investigate effectiveness of Arabic gum in inhibiting lipolytic activity pathogenic S. commonly found infections, through both lab-based animal experiments. We obtained 300 specimens from individuals who met clinical requirements various diseases four Egyptian hospitals: Al-Minshawi general hospital, Tanta University Kafr El-Zayat Mahalla respectively. determined isolates examined effect on mice against enzyme activity. treatment reduced at 1/2 MIC, 1/4 1/8 1/16 MIC by 84.1%, 68.7%, 81.6%, 68.6%, In male Sprague-Dawley mice, revealed significant improvement burn healing. All mouse groups used experiment showed better neovascularization re-epithelialization histological tests gum. Our results suggest help wounds heal faster affecting tissue regeneration. concluded promising antibacterial wound-healing properties infections.

Language: Английский

Citations

1
Recent Trends and Advances in Design of Rapid Tests for Colorimetric Detection of Staphylococcus aureus DOI

Cemile Yilmaz,

Çağla Çelik, Nilay Ildi̇z

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Staphylococcus aureus (S. aureus), which is a member of Micrococcacease family, one the most dangerous disease-causing bacteria. S. also biggest factor causing hospital-acquired infections worldwide, as well life-threatening such meningitis, septicaemia, and suppurating wounds in human body. Today, there have been various phenotypic and/or genotypic methods for detection both methicillin-resistant (MRSA) strains. Although commonly used certain rapid results, they are quite expensive rarely available all hospitals; need costly complicated devices expert use. To address these issues, researchers recently developed nanomaterials (NMs) organic molecules-based rapid, sensitive, economical MRSA. We focus on evaluating colorimetric assays using NMs pH indicator-containing tests cost-effective MRSA, specifically target their application clinical environmental contexts.

Language: Английский

Citations

1