Drug-induced hypokalemia: an analytical study based on real-world drug monitoring data DOI Creative Commons
Bo Song, Liheng Liu, Shichao Dong

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 20, 2025

Drug-induced hypokalemia is often associated with adverse clinical outcomes, and unfortunately, the inability to fully understand drugs that cause puts us in a passive position. This study applies pharmacovigilance data present panorama of suspected medications hyperkalemia. used disproportionality analysis mine events OpenFDA, identified all caused hypokalemia, coded classified according Anatomical Therapeutic Chemical (ATC) classification system. There are 19755 reports related drug-induced hypokalemia. The majority individuals females, concentrated age range 65 84 years old. After occurrence 8.02% died due 1141 drugs, among top 50 32 did not include their instructions. All can be categorized into 73 subgroups ATC By mining OpenFDA database, we have conducted comprehensive evaluation. instructions for most do focus on When treatment regimen includes other directly/indirectly decrease blood potassium, recommend actively monitoring potassium when using drugs.

Language: Английский

Drug-induced hypokalemia: an analytical study based on real-world drug monitoring data DOI Creative Commons
Bo Song, Liheng Liu, Shichao Dong

et al.

Expert Opinion on Drug Safety, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: Feb. 20, 2025

Drug-induced hypokalemia is often associated with adverse clinical outcomes, and unfortunately, the inability to fully understand drugs that cause puts us in a passive position. This study applies pharmacovigilance data present panorama of suspected medications hyperkalemia. used disproportionality analysis mine events OpenFDA, identified all caused hypokalemia, coded classified according Anatomical Therapeutic Chemical (ATC) classification system. There are 19755 reports related drug-induced hypokalemia. The majority individuals females, concentrated age range 65 84 years old. After occurrence 8.02% died due 1141 drugs, among top 50 32 did not include their instructions. All can be categorized into 73 subgroups ATC By mining OpenFDA database, we have conducted comprehensive evaluation. instructions for most do focus on When treatment regimen includes other directly/indirectly decrease blood potassium, recommend actively monitoring potassium when using drugs.

Language: Английский

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