Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(22), P. 7049 - 7049
Published: Nov. 12, 2023
Inflammation
is
an
important
component
of
the
etiopathology
depression
that
uses
oxidative
and
nitrosative
stress
(O&NS)
elevated
inflammatory
markers.
SARS-CoV-2
infection
also
associated
with
abnormal
processes,
which
may
impair
effective
treatment
in
COVID-19
survivors.
In
presented
study,
thirty-three
hospitalized
patients
major
depressive
disorder
(MDD)
were
started
on
antidepressant
treatment,
twenty-one
re-evaluated
after
4–6
weeks.
The
control
group
consisted
thirty
healthy
volunteers.
All
participants
underwent
neuropsychiatric
evaluation,
biochemical
blood
urine
analyses.
results
research
demonstrated
positive
correlations
Hamilton
Depression
Rating
Scale
(HAM-D)
scores
serum
catalase
(CAT)
urinary
S-Nitrosothiols
levels,
Beck
Inventory
(BDI)
reduced
glutathione
(GSH)
superoxide
dismutase
(SOD)
levels.
Depressed
a
history
prior
to
had
higher
nitric
oxide
(NO)
levels
lower
peroxidase
(GPx)
group,
survivors
N-formylkynurenine
(NFK).
Our
suggest
has
modulating
effect
O&NS,
reduces
symptoms
improves
cognitive
functions
present
study
does
not
indicate
clinical
response
baseline
antibody
Nevertheless,
further
this
area
needed
systematize
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 28, 2023
Introduction:
Glycoxidative
stress
is
essential
for
linking
glucose
disturbances
and
cardiovascular
diseases.
Unfortunately,
contemporary
antidiabetic
drugs
do
not
have
an
antiglycative
effect
but
only
lower
blood
levels.
Therefore,
there
intense
search
substances
that
could
inhibit
protein
glycation
prevent
diabetic
complications.
A
potential
antioxidant
activity
has
been
demonstrated
with
verapamil,
a
phenylalkylamine
derivative
belonging
to
selective
calcium
channel
blockers.
Verapamil
well-established
position
in
cardiology
due
its
wide
range
of
indications
good
safety
profile.
Nevertheless,
the
verapamil
still
unclear.
We
are
first
comprehensively
evaluate
verapamil’s
on
glycoxidation
using
various
vitro
silico
models.
Methods:
Bovine
serum
albumin
(BSA)
was
used
assess
rate
inhibition
by
verapamil.
As
glycating
factors,
sugars
(glucose,
fructose,
ribose)
aldehyde
(glyoxal)
were
used.
Chloramine
T
as
oxidizing
agent.
Aminoguanidine
(protein
inhibitor)
Trolox
(antioxidant)
control
substances.
The
biomarkers
oxidation
(total
thiols,
carbonyls,
advanced
products),
(Amadori
products,
β-amyloid,
end
products
[AGEs]),
(tryptophan,
kynurenine,
N-formylkynurenine,
dityrosine)
evaluated
colorimetric
fluorimetric
methods.
mechanism
assessed
docking
study
interaction
BSA,
glycosidases,
seventeen
AGE
pathway
proteins.
Results:
In
all
models,
glycation,
oxidation,
significantly
ameliorated
under
influence
comparable
potent
antiglycating
agents
antioxidants.
molecular
simulations
showed
bound
preferentially
amino
acids
prone
glycoxidative
damage
out
α-glucosidase’s
active
center.
Among
proteins,
best
docked
Janus
kinase
2
(JAK2)
nuclear
factor-κB
(NF-κB).
Discussion:
results
our
confirm
antiglycoxidant
properties
drug’s
action
recognized
protecting
against
oxidative
modifications.
may
be
particularly
helpful
patients
disease
concomitant
diabetes.
Studies
animal
models
humans
needed
antiglycative/antidiabetic
activity.
Future Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
16(18), P. 1853 - 1863
Published: Aug. 9, 2024
Derivatization
has
been
tremendously
utilized
in
the
field
of
drug
discovery
for
optimizing
pharmacological
properties
and
improving
safety,
efficacy
selectivity.
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(22), P. 7049 - 7049
Published: Nov. 12, 2023
Inflammation
is
an
important
component
of
the
etiopathology
depression
that
uses
oxidative
and
nitrosative
stress
(O&NS)
elevated
inflammatory
markers.
SARS-CoV-2
infection
also
associated
with
abnormal
processes,
which
may
impair
effective
treatment
in
COVID-19
survivors.
In
presented
study,
thirty-three
hospitalized
patients
major
depressive
disorder
(MDD)
were
started
on
antidepressant
treatment,
twenty-one
re-evaluated
after
4–6
weeks.
The
control
group
consisted
thirty
healthy
volunteers.
All
participants
underwent
neuropsychiatric
evaluation,
biochemical
blood
urine
analyses.
results
research
demonstrated
positive
correlations
Hamilton
Depression
Rating
Scale
(HAM-D)
scores
serum
catalase
(CAT)
urinary
S-Nitrosothiols
levels,
Beck
Inventory
(BDI)
reduced
glutathione
(GSH)
superoxide
dismutase
(SOD)
levels.
Depressed
a
history
prior
to
had
higher
nitric
oxide
(NO)
levels
lower
peroxidase
(GPx)
group,
survivors
N-formylkynurenine
(NFK).
Our
suggest
has
modulating
effect
O&NS,
reduces
symptoms
improves
cognitive
functions
present
study
does
not
indicate
clinical
response
baseline
antibody
Nevertheless,
further
this
area
needed
systematize
