Predictors of nirmatrelvir–ritonavir receipt among COVID-19 patients in a large US health system
Deborah E. Malden,
No information about this author
John M. McLaughlin,
No information about this author
Vennis Hong
No information about this author
et al.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: March 29, 2024
Abstract
A
clear
understanding
of
real-world
uptake
nirmatrelvir–ritonavir
for
treatment
SARS-CoV-2
can
inform
allocation
strategies
and
improve
interpretation
effectiveness
studies.
We
used
data
from
a
large
US
healthcare
system
to
describe
dispenses
among
all
positive
patients
aged
≥
12
years
meeting
recommended
National
Institutes
Health
eligibility
criteria
the
study
period
between
1
January
31
December,
2022.
Overall,
10.9%
(N
=
34,791/319,900)
eligible
with
infections
received
over
period.
Although
increased
time,
by
end
2022,
less
than
quarter
had
nirmatrelvir–ritonavir.
Across
patient
demographics,
was
generally
consistent
tiered
guidelines,
concentrated
65
(14,706/63,921;
23.0%),
multiple
comorbidities
(10,989/54,431;
20.1%).
However,
neighborhoods
lower
socioeconomic
status
(upper
third
neighborhood
deprivation
index
[NDI])
12%
(95%
CI:
7–18%)
28%
(25–32%)
odds
dispense
time
periods
studied
compared
NDI
distribution,
even
after
accounting
demographic
clinical
characteristics.
limited
chart
review
40)
confirmed
that
in
some
cases
decision
not
treat
appropriate
aligned
national
guidelines
use
judgement
on
case-by-case
basis.
There
is
need
enhance
provider
awareness
availability
benefits
COVID-19
illness.
Language: Английский
Spatiotemporal Trends in Self-Reported Mask-Wearing Behavior in the United States: Analysis of a Large Cross-sectional Survey
JMIR Public Health and Surveillance,
Journal Year:
2023,
Volume and Issue:
9, P. e42128 - e42128
Published: March 6, 2023
Face
mask
wearing
has
been
identified
as
an
effective
strategy
to
prevent
the
transmission
of
SARS-CoV-2,
yet
mandates
were
never
imposed
nationally
in
United
States.
This
decision
resulted
a
patchwork
local
policies
and
varying
compliance,
potentially
generating
heterogeneities
trajectories
COVID-19
Although
numerous
studies
have
investigated
patterns
predictors
masking
behavior
nationally,
most
suffer
from
survey
biases
none
able
characterize
at
fine
spatial
scales
across
States
through
different
phases
pandemic.Urgently
needed
is
debiased
spatiotemporal
characterization
mask-wearing
information
critical
further
assess
effectiveness
masking,
evaluate
drivers
time
points
during
pandemic,
guide
future
public
health
decisions
through,
for
example,
forecasting
disease
surges.We
analyzed
over
8
million
behavioral
responses
States,
starting
September
2020
May
2021.
We
adjusted
sample
size
representation
using
binomial
regression
models
raking,
respectively,
produce
county-level
monthly
estimates
behavior.
additionally
self-reported
bias
measures
derived
by
comparing
vaccination
data
same
official
records
county
level.
Lastly,
we
evaluated
whether
individuals'
perceptions
their
social
environment
can
serve
less
biased
form
surveillance
than
data.We
found
that
was
spatially
heterogeneous
along
urban-rural
gradient,
with
peaking
winter
2021
declining
sharply
Our
results
regions
where
targeted
efforts
could
suggest
frequency
may
be
influenced
national
guidance
prevalence.
validated
our
correction
approach
community-reported
estimates,
after
addressing
issues
small
representation.
Self-reported
especially
prone
desirability
nonresponse
biases,
findings
demonstrated
these
reduced
if
individuals
are
asked
report
on
community
rather
self
behaviors.Our
work
highlights
importance
characterizing
behaviors
capture
drive
outbreak
trajectories.
also
emphasize
need
standardized
incorporating
big
into
response
efforts.
Even
large
surveys
bias;
thus,
advocate
sensing
enable
more
accurate
behaviors.
Finally,
invite
research
communities
use
publicly
available
consider
how
bias-corrected
improve
understanding
protective
crises
impact
dynamics.
Language: Английский
Resurgence of Kawasaki Disease Following Relaxation of Coronavirus Disease 2019 Pandemic Restrictions in Japan
The Journal of Pediatrics,
Journal Year:
2024,
Volume and Issue:
275, P. 114251 - 114251
Published: Aug. 23, 2024
Language: Английский
The effect of COVID-19 infection on patients with rheumatic diseases in China
Clinical Rheumatology,
Journal Year:
2024,
Volume and Issue:
43(3), P. 1199 - 1206
Published: Jan. 29, 2024
Language: Английский
Invited Commentary: To Make Long-Term Gains Against Infection Inequity, Infectious Disease Epidemiology Needs to Develop a More Sociological Imagination
American Journal of Epidemiology,
Journal Year:
2023,
Volume and Issue:
192(7), P. 1047 - 1051
Published: Feb. 24, 2023
In
a
recent
article
in
the
Journal,
Noppert
et
al.
(Am
J
Epidemiol.
2023;192(3):475-482)
articulated
detail
mechanisms
connecting
high-level
"fundamental
social
causes"
of
health
inequity
to
inequitable
infectious
disease
outcomes,
including
infection,
severe
disease,
and
death.
this
commentary,
we
argue
that
while
intensive
focus
on
intervening
is
welcome
necessary,
it
cannot
occur
isolation
from
examination
way
fundamental
causes-including
racism,
socioeconomic
inequity,
stigma-sustain
infection
inequities
even
when
are
addressed.
We
build
taxonomy
laid
out
by
create
road
map
for
strengthening
connection
between
cause
theory
epidemiology
discuss
its
implications
future
research
intervention.
Language: Английский
Using an integrated social cognition model to identify the determinants of QR code check-in compliance behaviors in the COVID-19 pandemic
Journal of Health Psychology,
Journal Year:
2023,
Volume and Issue:
29(6), P. 495 - 509
Published: Nov. 8, 2023
In
Australia,
checking
in
while
entering
venues
was
a
legal
requirement
during
the
COVID-19
pandemic
to
track
potential
infection
sites.
This
two-wave
correlational
study
used
an
integrated
theory
of
planned
behavior
model
including
moral
norms,
anticipated
regret,
and
habit
predict
check-in
compliance
sample
181
Victorians
(Mean
Age
=
41.88,
56.4%
female)
162
Queenslanders
43.26,
47.5%
female).
Habit
intention
predicted
behavior,
perceived
behavioral
control
did
not.
Intention
by
baseline
habit,
attitude,
subjective
norm,
norm
Victorian
sample,
only
Queensland
sample.
has
implications
for
reviewing
previous
strategies
future
preparedness,
both
identifying
drivers
compliance,
through
discussion
how
differences
effects
between
states
may
be
linked
each
state’s
experience
(e.g.
rates,
lockdown
length).
Language: Английский
Liminal Stigma and the Interference With the Positive Construction of Face Masks: The Case of Online Reactions to an Anti-Mask Rally
Humanity & Society,
Journal Year:
2024,
Volume and Issue:
48(2-4), P. 179 - 203
Published: July 19, 2024
Masks
emerged
as
one
of
the
few
means
responding
to
COVID-19
pandemic.
A
significant
minority
Americans,
however,
resisted
emergent
mask
wearing
norm.
This
study
seeks
examine
ways
that
constructions
use
an
appropriate
alleviation
threat
posed
by
was
disrupted
in
public
discourse.
It
does
so
employing
a
qualitative
content
analysis
comments
made
on
Twitter,
Reddit,
and
YouTube
response
burning
rally
held
Boise,
Idaho
March
2021.
Guided
literature
aligning
activity,
this
identifies
four
processes
which
positive
definition
undermined.
Through
fragmentation,
neutralization,
dilution,
displacement,
official
complicated
competing
definitions
conduct
also
contested
evaluations
identities.
These
findings
provide
further
understanding
obstacles
coordination
during
role
activity
plays
obstacle
social
construction
danger
absence
established
norms.
Language: Английский
An assessment on the interplay of digital proximity app use and vaccine uptake for SARS-CoV-2 transmission mitigation in Switzerland
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 19, 2023
Abstract
Introduction
Adherence
to
digital
proximity
tracing
apps
and
preventive
measures
leading
up
following
widespread
SARS-CoV-2
vaccine
rollout
remains
unclear.
Our
study
aims
evaluate
the
relative
effect
of
app
use,
uptake
adherence
additional
in
a
localized
context
pandemic.
Methods
We
report
findings
from
two
population-based
longitudinal
cohorts
Switzerland,
Corona
Immunitas
Digital
Follow-up
eCohort
(CI-DFU)
COVID-19
Social
Monitor
(CSM)
studies
2021.
Failure
time
analyses
were
conducted
for
each
cohort,
stratified
by
age
group.
Cox
proportional
hazards
regression
models
with
time-varying
covariates
used
estimate
adjusted
hazard
ratios
(aHR).
The
assessed
SwissCovid
uninstalling
outcomes,
outcomes
interchanging
as
exposures
separate
substudies.
Results
observed
dichotomy
individuals
who
did
not
use
during
period
get
vaccinated,
got
vaccinated
period.
found
an
increased
associated
(aHR,
1.51;
95%
CI:
1.40–1.62
[CI-DFU];
aHR,
1.79;
1.62–1.99
[CSM])
or
1.44;
1.28–1.62
1.82;
1.52–2.18
[CSM]).
Decreased
uninstallation
risk
was
participants
received
their
first
dose
throughout
0.55;
0.38–0.81
0.45;
0.27–0.78
Conclusion
In
evolving
pandemic
contexts,
these
can
assist
public
health
authorities
designing
evidence-based
communication
strategies
enable
adoption
novel
technologies
across
all
population
groups.
Language: Английский
Interplay of Digital Proximity App Use and SARS-CoV-2 Vaccine Uptake in Switzerland: Analysis of Two Population-Based Cohort Studies
International Journal of Public Health,
Journal Year:
2023,
Volume and Issue:
68
Published: Sept. 20, 2023
Objectives:
Our
study
aims
to
evaluate
developments
in
vaccine
uptake
and
digital
proximity
tracing
app
use
a
localized
context
of
the
SARS-CoV-2
pandemic.
Methods:
We
report
findings
from
two
population-based
longitudinal
cohorts
Switzerland
January
December
2021.
Failure
time
analyses
Cox
proportional
hazards
regression
models
were
conducted
assess
(SwissCovid)
uninstalling
outcomes.
Results:
observed
dichotomy
individuals
who
did
not
SwissCovid
get
vaccinated,
used
got
vaccinated
during
period.
Increased
was
with
(aHR,
1.51;
95%
CI:
1.40-1.62
[CI-DFU];
aHR,
1.79;
1.62-1.99
[CSM])
compared
non-use.
Decreased
uninstallation
risk
for
participants
0.55;
0.38-0.81
0.45;
0.27-0.78
vaccinated.
Conclusion:
In
evolving
epidemic
contexts,
these
underscore
need
communication
strategies
as
well
flexible
adjustments
that
accommodate
different
preventive
measures
their
anticipated
interactions.
Language: Английский
Spatiotemporal trends in self-reported mask-wearing behavior in the United States: Analysis of a large cross-sectional survey
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2022,
Volume and Issue:
unknown
Published: July 22, 2022
Face
mask-wearing
has
been
identified
as
an
effective
strategy
to
prevent
transmission
of
SARS-CoV-2,
yet
mask
mandates
were
never
imposed
nationally
in
the
United
States.
This
decision
resulted
a
patchwork
local
policies
and
varying
compliance
potentially
generating
heterogeneities
trajectories
COVID-19
U.S.
While
numerous
studies
have
investigated
patterns
predictors
masking
behavior
nationally,
most
suffer
from
survey
biases
none
able
characterize
at
fine
spatial
scales
across
through
different
phases
pandemic.Urgently
needed
is
debiased
spatiotemporal
characterization
information
critical
further
assess
effectiveness
masking,
evaluate
drivers
time
points
during
pandemic,
guide
future
public
health
decisions
through,
for
example,
forecasting
disease
surges.We
analyze
over
eight
million
behavioral
responses
States
starting
September
2020
May
2021.
We
adjust
sample
size
representation
using
binomial
regression
models
raking,
respectively,
produce
county-level
monthly
estimates
behavior.
additionally
debias
self-reported
bias
measures
derived
by
comparing
vaccination
data
same
official
records
county-level.
Lastly,
we
whether
individuals'
perceptions
their
social
environment
can
serve
less
biased
form
surveillance
than
data.We
find
that
spatially
heterogeneous
along
urban-rural
gradient,
with
peaking
winter
2021
declining
sharply
Our
results
identify
regions
where
targeted
efforts
could
suggest
frequency
may
be
influenced
national
guidance
prevalence.
validate
our
bias-correction
approach
community-reported
estimates,
after
addressing
issues
small
representation.
Self-reported
are
especially
prone
desirability
non-response
findings
demonstrate
these
reduced
if
individuals
asked
report
on
community
rather
self
behaviors.Our
work
highlights
importance
characterizing
behaviors
capture
drive
outbreak
trajectories.
also
emphasize
need
standardized
incorporating
big
into
response
efforts.
Even
large
surveys
bias;
thus,
advocate
sensing
enable
more
accurate
behaviors.
Finally,
invite
research
communities
use
publicly
available
consider
how
bias-corrected
improve
understanding
protective
crises
impact
dynamics.
Language: Английский