Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer DOI Creative Commons
Jean‐François Rossi,

Patrick Frayssinet,

Maksim Matciyak

et al.

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: 20(12), P. 1021 - 1034

Published: Feb. 5, 2024

Immune adjuvants are immune modulators that have been developed in the context of infectious vaccinations. There is currently a growing interest due to development immunotherapy against cancers. adjuvant mechanisms action focused on initiation and amplification inflammatory response leading innate response, followed by adaptive response. The main activity lies support antigen presentation maturation functions dendritic cells. Most associated with vaccine or incorporated into new generation mRNA vaccines. Few used as drugs. Hydroxyapatite (HA) ceramics azoximer bromide (AZB) overlooked molecules were early clinical trials, which demonstrated efficacy excellent tolerance profiles. HA combined an autologous was previously veterinary field for use canine spontaneous lymphomas. AZB, original modulator derived from class heterochain aliphatic polyamines licensed Russia, Commonwealth Independent States, Slovakia diseases, now being cancer promising results. These two can be various strategies.

Language: Английский

The quest for nanoparticle-powered vaccines in cancer immunotherapy DOI Creative Commons
Zhe Sun,

Hui Zhao,

Li Ma

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Language: Английский

Citations

27
mRNA vaccine platforms: linking infectious disease prevention and cancer immunotherapy DOI Creative Commons
Dariush Haghmorad, Majid Eslami,

Niloufar Orooji

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 12, 2025

The advent of mRNA vaccines, accelerated by the global response to COVID-19 pandemic, marks a transformative shift in vaccine technology. In this article, we discuss development, current applications, and prospects vaccines for both prevention treatment infectious diseases oncology. By leveraging capacity encode antigens within host cells directly, provide versatile scalable platform suitable addressing broad spectrum pathogens tumor-specific antigens. We highlight recent advancements design, innovative delivery mechanisms, ongoing clinical trials, with particular emphasis on their efficacy combating diseases, such as COVID-19, Zika, influenza, well emerging potential cancer immunotherapy. also address critical challenges, including stability, optimization immune responses, broader issue accessibility. Finally, review strategies advancing next-generation aim overcoming limitations technology enhancing preventive therapeutic approaches oncological diseases.

Language: Английский

Citations

1
A Minimalist Pathogen‐Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy DOI Open Access

Miao Yu,

Le Niu,

Xinying Lv

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Pathogen-mimicking nanoparticles have emerged at the forefront of vaccine delivery technology, offering potent immune activation and excellent biocompatibility. Among these innovative carriers, mannan, a critical component yeast cell walls, shows promise as an exemplary carrier. Nevertheless, it faces challenges like unpredictable immunogenicity, rapid elimination, limited antigen loading due to high water solubility. Herein, mannan with varying carbon chain ratios is innovatively modified, yielding series dodecyl chains modified (Mann-C

Language: Английский

Citations

7
Process Optimization of Scaled-Up Production and Biosafety Evaluation of the Dimethyl-Dioctadecyl-Ammonium Bromide/Poly(lactic acid) Nano-Vaccine DOI Creative Commons

Hengye Yang,

Yuan Gao, Meijuan Liu

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(5), P. 127 - 127

Published: May 14, 2024

Nano-adjuvant vaccines could induce immune responses and enhance immunogenicity. However, the application manufacturing of nano-adjuvant is hampered by its challenging scale-up, poor reproducibility, low security. Therefore, present study aimed to optimize preparation nanoparticles (NPs) using FDA-approved biopolymer materials poly(lactic acid) (PLA) cationic lipid didodecyl-dimethyl-ammonium bromide (DDAB), develop scale-up process, evaluate stability biosafety it. The optimum conditions DDAB/PLA NPs on a small scale were as follows: DDAB amount 30 mg, aqueous phase volume 90 mL, stirring rate at 550 rpm, solidifying time 12 h. Under conditions, size was about 170 nm. In experiments, vacuum rotary evaporation 6 h Tangential flow ultrafiltration (TFU) method conditions. results suggested that exhibited uniform particle distribution, with an average 150.3 ± 10.4 nm narrow polydispersity index (PDI) 0.090 0.13, coupled high antigen loading capacity 85.4 4.0%. addition, can be stored stably for days do not have side effects caused residual solvents. For biosafety, acute toxicity experiments showed good tolerance vaccine formulation even adjuvant dose. local irritation experiment demonstrated reversibility muscular irritation, repeated revealed no significant necrosis or severe lesions in mice injected high-dose formulation. Overall, exhibit potential clinical translation safe candidate adjuvant.

Language: Английский

Citations

2
Investigation on the immune effect of a chitosan-based particle-in-oil-in-water emulsion DOI
Lanxin Li, Yanan Li, Yanan Peng

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 128, P. 111468 - 111468

Published: Jan. 2, 2024

Language: Английский

Citations

1
Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond DOI
Mohit Kumar,

Nitasha Chauhan,

Devesh Kumar

et al.

Journal of Dispersion Science and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: June 20, 2024

Nanoemulsions are nano-sized particles, typically ranging from tens to hundreds of nanometers. These nanoemulsions possess various appealing properties, making them highly promising for applications in pharmaceutics, foods, and cosmetics. properties include their small size, which allows a high surface area per unit volume, ability disperse hydrophobic components enhance absorption effectively. In the pharmaceutical industry, have been developed delivery active ingredients. Macromolecular surfactants offer enhanced emulsion stability compared conventional low-molecular surfactants. Enhanced is due slower desorption kinetics at droplet interface, reduces risk toxicity skin irritation associated with latter. This article presents comprehensive investigation into role drug delivery. It commences by delineating types subsequently explores techniques nanoemulsion preparation. Surfactants serve as pivotal both production stabilization nanoemulsions. The review provides an encompassing overview diverse surfactant types, molecule variants, particle surfactants, phospholipids, peptides, protein-based tailored Additionally, it addresses instability, elucidating strategies mitigate instability challenges, highlights utilization nanomedicine effective aims insights researchers engaged nanoemulsion-related studies interdisciplinary fields.

Language: Английский

Citations

1
Construction of Candida albicans Adhesin-Exposed Synthetic Cells for Preventing Systemic Fungal Infection DOI Creative Commons
Zirun Zhao, Ying Sun, Mingchun Li

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(10), P. 1521 - 1521

Published: Sept. 25, 2023

The development of efficient fungal vaccines is urgent for preventing life-threatening systemic infections. In this study, we prepared a synthetic, cell-based vaccine infections using synthetic biology techniques. cell EmEAP1 was constructed by transforming the Escherichia coli chassis de novo fragment encoding protein mChEap1 that composed E. OmpA peptide, fluorescence mCherry, Candida albicans adhesin Eap1, and C-terminally transmembrane region. cells highly exposed on surface under IPTG induction. then mixing with aluminum hydroxide gel CpG. Fluorescence quantification revealed stable even after 112 days storage. After immunization in mice, resided lymph nodes, inducing recruitment CD11c+ dendritic cells. Moreover, strongly activated CD4+ T splenocytes elicited high levels anti-Eap1 IgG. By prime-boost immunization, prolonged survival time mice infected C. attenuated colonization together inflammation kidneys. This study sheds light biology-based prevention

Language: Английский

Citations

1
Azoximer bromide and hydroxyapatite: promising immune adjuvants in cancer DOI Creative Commons
Jean‐François Rossi,

Patrick Frayssinet,

Maksim Matciyak

et al.

Cancer Biology and Medicine, Journal Year: 2024, Volume and Issue: 20(12), P. 1021 - 1034

Published: Feb. 5, 2024

Immune adjuvants are immune modulators that have been developed in the context of infectious vaccinations. There is currently a growing interest due to development immunotherapy against cancers. adjuvant mechanisms action focused on initiation and amplification inflammatory response leading innate response, followed by adaptive response. The main activity lies support antigen presentation maturation functions dendritic cells. Most associated with vaccine or incorporated into new generation mRNA vaccines. Few used as drugs. Hydroxyapatite (HA) ceramics azoximer bromide (AZB) overlooked molecules were early clinical trials, which demonstrated efficacy excellent tolerance profiles. HA combined an autologous was previously veterinary field for use canine spontaneous lymphomas. AZB, original modulator derived from class heterochain aliphatic polyamines licensed Russia, Commonwealth Independent States, Slovakia diseases, now being cancer promising results. These two can be various strategies.

Language: Английский

Citations

0