Frontiers in Systems Biology,
Journal Year:
2024,
Volume and Issue:
4
Published: Nov. 13, 2024
Circular
RNAs
(circRNAs)
have
gained
prominence
as
important
players
in
various
biological
processes
such
gastric
cancer
(GC).
Identification
of
several
dysregulated
circRNAs
may
serve
biomarkers
for
early
diagnosis
or
novel
therapeutic
targets.
Predictive
models
can
suggest
potential
new
interactions
and
regulatory
roles
GCs.
Experimental
validations
key
are
being
performed
using
vitro
models,
confirming
the
significance
identified
circRNA
networks.
The
aim
this
review
is
to
highlight
associated
with
GC.
On
top
that
an
overview
mechanistic
details
biogenesis
functionalities
also
presented.
Furthermore,
potentialities
field
drug
discovery
deciphered.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 12, 2025
The
advent
of
mRNA
vaccines,
accelerated
by
the
global
response
to
COVID-19
pandemic,
marks
a
transformative
shift
in
vaccine
technology.
In
this
article,
we
discuss
development,
current
applications,
and
prospects
vaccines
for
both
prevention
treatment
infectious
diseases
oncology.
By
leveraging
capacity
encode
antigens
within
host
cells
directly,
provide
versatile
scalable
platform
suitable
addressing
broad
spectrum
pathogens
tumor-specific
antigens.
We
highlight
recent
advancements
design,
innovative
delivery
mechanisms,
ongoing
clinical
trials,
with
particular
emphasis
on
their
efficacy
combating
diseases,
such
as
COVID-19,
Zika,
influenza,
well
emerging
potential
cancer
immunotherapy.
also
address
critical
challenges,
including
stability,
optimization
immune
responses,
broader
issue
accessibility.
Finally,
review
strategies
advancing
next-generation
aim
overcoming
limitations
technology
enhancing
preventive
therapeutic
approaches
oncological
diseases.
Vaccines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 126 - 126
Published: Jan. 27, 2025
Infectious
diseases
continue
to
pose
a
significant
global
health
threat.
To
combat
these
challenges,
innovative
vaccine
technologies
are
urgently
needed.
Nanoparticles
(NPs)
have
unique
properties
and
emerged
as
promising
platform
for
developing
next-generation
vaccines.
revolutionizing
the
field
of
development,
offering
new
era
immunization.
They
allow
creation
more
effective,
stable,
easily
deliverable
Various
types
NPs,
including
lipid,
polymeric,
metal,
virus-like
particles,
can
be
employed
encapsulate
deliver
components,
such
mRNA
or
protein
antigens.
These
NPs
protect
antigens
from
degradation,
target
them
specific
immune
cells,
enhance
antigen
presentation,
leading
robust
durable
responses.
Additionally,
simultaneously
multiple
antigens,
adjuvants,
in
single
formulation,
simplifying
production
administration.
Nanovaccines
offer
approach
food-
water-borne
bacterial
diseases,
surpassing
traditional
formulations.
Further
research
is
needed
address
burden
infections.
This
review
highlights
potential
revolutionize
platforms.
We
explore
their
mechanisms
action,
current
applications,
emerging
trends.
The
discusses
limitations
nanovaccines,
solutions
role
artificial
intelligence
effective
accessible
nanovaccines
infectious
diseases.
The AAPS Journal,
Journal Year:
2025,
Volume and Issue:
27(4)
Published: May 19, 2025
Abstract
Quality
by
Design
(QbD)
is
a
transformative
and
systematic
approach
to
developing
top-tier
pharmaceutical
products,
ushering
in
departure
from
traditional
trial-and-error
methods
toward
more
science-based,
risk-oriented,
holistic
strategy.
Central
QbD
implementation
the
meticulous
development
of
formulations
manufacturing
processes,
consistently
fulfilling
predefined
quality
objectives.
The
core
objective
remains
unwavering
—
guarantee
steadfast
alignment
final
product
with
predetermined
attributes,
thereby
mitigating
batch-to-batch
variations
potential
recalls.
This
article
succinctly
explores
multifaceted
application
methodology
within
industry.
Emphasizing
its
pivotal
role
research
development,
manufacturing,
control,
assurance,
discussion
navigates
through
strategic
deployment
elements
tools.
Amidst
evident
advantages
QbD,
challenges
persist
widespread
adoption
sector
regulatory
frameworks.
sheds
light
on
landscape
that
currently
governs
these
crucial
stages
processes.
For
reason,
this
review
aims
provide
researchers,
scientists,
industry
professionals
thorough
introduction
so
they
may
adopt
methodical
producing
high-quality
always
compliance
underlying
regulations.
Graphical
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(5), P. 659 - 659
Published: May 17, 2025
Background/Objectives:
Traditional
Quality
by
Testing
(QbT)
strategies
rely
heavily
on
end-product
testing
and
offer
limited
insight
into
how
critical
process
parameters
(CPPs)
influence
product
quality.
This
increases
the
risk
of
variability
inconsistent
outcomes.
To
overcome
these
limitations,
this
study
aimed
to
implement
a
Design
(QbD)
approach
optimize
manufacturing
clopidogrel
tablets.
Methods:
A
science-
risk-based
QbD
framework
was
applied
identify
prioritize
key
CPPs,
intermediate
quality
attributes
(iCQAs),
final
CQAs
across
unit
operations—pre-blending,
dry
granulation,
post-blending,
lubrication,
compression.
Risk
assessment
tools
statistical
design
experiments
(DoE)
were
used
define
proven
acceptable
ranges
(PARs).
Results:
The
revealed
strong
correlations
between
CPPs
CQAs,
allowing
definition
PARs
development
robust
control
strategy.
led
improved
consistency,
reduced
variability,
enhanced
understanding.
Conclusions:
minimized
reliance
while
ensuring
high-quality
offers
novel
implementation
tailored
challenges
tablets,
providing
validated
that
integrates
granulation
with
process-specific
CQAs.
These
results
demonstrate
value
in
achieving
pharmaceutical
meeting
regulatory
expectations.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 992 - 992
Published: Aug. 30, 2024
Since
their
conception
with
the
smallpox
vaccine,
vaccines
used
worldwide
have
mitigated
multiple
pandemics,
including
recent
COVID-19
outbreak.
Insightful
studies
uncovered
complexities
of
different
functional
networks
CD4
T
cells
(T
helper
1
(Th1);
Th2,
Th17)
and
CD8
cytotoxic;
Tc),
as
well
B
cell
(B
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(12), P. 1382 - 1382
Published: Dec. 7, 2024
Influenza
poses
a
significant
global
health
challenge
due
to
its
rapid
mutation
and
antigenic
variability,
which
often
leads
seasonal
epidemics
frequent
outbreaks.
Traditional
vaccines
struggle
offer
comprehensive
protection
because
of
mismatches
with
circulating
viral
strains.
The
development
broad-spectrum
vaccine
is
therefore
crucial.
This
paper
explores
the
potential
mRNA
technology
address
these
challenges
by
providing
swift,
adaptable,
broad
protective
response
against
evolving
influenza
We
detail
mechanisms
variation
in
viruses
discuss
design
production,
enhanced
immunogenicity,
encoding
multiple
antigens,
safety
stability
compared
traditional
methods.
By
leveraging
advantages,
represent
revolutionary
approach
prevention,
potentially
offering
significantly
improving
management
strategies.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 23, 2024
Today,
lipid
nanoparticles
(LNPs)
are
some
of
the
main
delivery
systems
for
mRNA-based
therapeutics.
The
scope
LNP
applications
in
terms
RNA
is
not
limited
to
antiviral
vaccines
but
encompasses
anticancer
drugs
and
therapeutics
genetic
(including
rare)
diseases.
Such
widespread
use
implies
high
customizability
targeted
LNPs
specific
organs
tissues.
This
review
addresses
vector-free
options
LNPs,
namely
influence
composition
these
on
their
biodistribution.
In
review,
experimental
studies
examined
that
focused
biodistribution
mRNA
or
encoded
protein
after
administration
via
mammals.
We
also
performed
a
comprehensive
analysis
individual
lipids’
functional
groups
ensure
desired
organs.
These
data
will
allow
us
outline
prospects
further
optimization
compositions
