Impacto da infecção pelo SARS-CoV-2 nos resultados gestacionais e neonatais em gestantes acompanhadas no Hospital das Clínicas da Faculdade de Medicina e no Hospital Universitário da USP DOI Creative Commons
Úrsula Trovato Gomez

Published: Nov. 23, 2022

Objetivo: Determinar os fatores clínicos e epidemiológicos associados à gravidade do quadro clínico em mulheres gestantes infectadas pelo SARS-CoV-2 o risco de resultados gestacionais neonatais adversos acordo com a da infecção.Métodos: Análise retrospectiva dados coletados forma prospectiva testadas para (ensaios sorológicos e/ou moleculares) durante gravidez no parto dois hospitais São Paulo período 12 abril 2020 28 fevereiro 2021.Cinco grupos foram criados: C0, investigação negativa ausência sintomas COVID-19 ou parto; C1, positiva sintomas; C2, presença leves; C3, internação moderado; C4, grave.A associação foi determinada por análise multivariada (AMV).Resultados: Foram incluídas 734 elegíveis, seguinte forma: C0 (n= 357), C1 127), C2 174), C3 37), C4 39).Idade materna mais avançada apresentou piora clínica (p= 0,044), nuliparidade menos frequente nos casos moderados graves (ORa= 0,30; IC 95% 0,12 -0,79 ORa= -0,76, respectivamente), enquanto hipertensão crônica 5,21; 2,09 -13,0) diabetes pré-existente, leves 4,27; 1,43 -11,71).Em comparação infecção (grupo C0), seguintes grave: oligoâmnio 6,18; 1,87 -20,39), sofrimento fetal 4,01; 1,84 -8,75), prematuro 5,51; 1,47 -20,61), maior tempo 1,66; 1,36 -2,02) unidade terapia intensiva neonatal 19,36; 5,86 -63,99).Todos óbitos maternos 6; 15,4%; p< 0,001) 5; 12,5%; p<0,001), maioria dos fetais 4; 9,8%; p<0,001) ocorreram COVID-19.A moderada associada 6,23; 1,93 -20,13) 3,60; 1,45 -9,27).COVID-19 leve 3,77; 1,56 -9,07).Conclusão: Progressão idade materna, multiparidade antecedentes arterial correlacionaram-se grave.

Severe Acute Respiratory Syndrome Coronavirus 2 Infection Symptoms in Pregnancy and Maternal and Neonatal Complications Due to COVID-19: A Systematic Review DOI Creative Commons

Maryam Derakhshani,

Sepideh Miraj, Azadeh Asgarian

et al.

Journal of Human Reproductive Sciences, Journal Year: 2023, Volume and Issue: 16(2), P. 90 - 98

Published: April 1, 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnant women is associated with severe maternal and neonatal complications including newborn death.This review aimed to assess the SARS-CoV-2 symptoms during pregnancy as well Iran.A developing low-income country a systematic review.International scientific databases PubMed, Web of Science, Scopus Google Scholar were searched manner. Two independent researchers checked identified articles from September 2019 2022 based on eligibility criteria quality appraisal. The results reported two sections outcomes.Descriptive statistics was used for statistical analysis.Seventeen studies 870 mothers COVID-19 met reviewed. main consequences intensive care unit (ICU) admission, pre-term delivery, death, pre-mature rupture membranes, pre-eclampsia, intrauterine growth retardation stillbirth. Neonatal ICU sepsis, low birth weight distress syndrome, tachypnoea, asphyxia pneumothorax most common outcomes offspring subjects.Pregnant are at higher risk being admitted mechanical ventilation consequently death. Comparing foetal different ethnicities, regions countries may be related socioeconomic status people should considered respect determines. Moreover, due Iran other seem than countries.

Language: Английский

Citations

2

CO-Sprout—A Pilot Double-Blinded Placebo-Controlled Randomised Trial of Broccoli Sprout Powder Supplementation for Pregnant Women with COVID-19 on the Duration of COVID-19-Associated Symptoms: Study Protocol DOI Open Access
Neville J. Fields, Kirsten R. Palmer, Daniel L. Rolnik

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(18), P. 3980 - 3980

Published: Sept. 14, 2023

Since its discovery in late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been estimated to be responsible for at least 769.3 million infections and over 6.95 deaths. Despite significant global vaccination efforts, there are limited therapies that considered safe effective use management of COVID-19 during pregnancy despite common knowledge pregnant patients have a much higher risk adverse outcomes. A bioactive compound found broccoli sprout—sulforaphane—is potent inducer phase-II detoxification enzymes promoting series potentially beneficial effects notably as an antioxidant, anti-inflammatory, anti-viral. pilot, double-blinded, placebo-controlled randomised trial is conducted Melbourne, Australia, across both public private hospital sectors. We will assess commercially available sprout extract women between 20+0 36+0 weeks gestation with SARS-CoV-2 infection investigate (i) duration associated symptoms, (ii) maternal neonatal outcomes, (iii) biomarkers inflammation. plan enrol 60 outpatient irrespective status diagnosed by PCR swab or RAT (rapid antigen test) within five days 14 oral (42 mg sulforaphane daily) identical microcrystalline cellulose placebo. The primary outcome this pilot feasibility conducting larger investigating (days) COVID-19-associated symptoms using supplement COVID-19-affected pregnancies. Pregnant remain at-risk group disease following currently unclear consequences offspring. Therefore, study supplement, whilst providing important safety data pregnancy.

Language: Английский

Citations

2

Clinical-epidemiological characteristics and maternal-foetal outcomes in pregnant women hospitalised with COVID-19 in Venezuela: a retrospective study DOI Creative Commons
Fhabián S. Carrión‐Nessi,

Mercedes P. Castro,

Diana C. Freitas-De Nobrega

et al.

BMC Pregnancy and Childbirth, Journal Year: 2022, Volume and Issue: 22(1)

Published: Dec. 5, 2022

In low- and middle-income countries, pregnant women newborns are more vulnerable to adverse outcomes from coronavirus disease 2019 (COVID-19). However, in Venezuela, there no integrated data a national surveillance system identify the clinical-epidemiological characteristics maternal-foetal of hospitalised with COVID-19.A retrospective study was conducted among Venezuelan COVID-19 seen at "Ruiz y Páez" University Hospital Complex San Cristobal Central between June 2020 September 2021. Information obtained physical digitised clinical records using purpose-designed proforma collect epidemiological, clinical, paraclinical, treatment, obstetric perinatal complications, data.A total 80 confirmed severe acute respiratory syndrome 2 infection were within period, 59 (73.8%) survived 21 (26.2%) died. The median (interquartile range) age 29 (23-33) years, majority being third trimester pregnancy (81.2%; n = 65). Interestingly, four (5%) co-infected malaria by Plasmodium vivax three (3.8%) syphilis. most frequent symptoms fever (75%; 60), dry cough (68.8%; 55), dyspnoea (55%; 44), headache (53.8%; 43). maternal complications anaemia (51.5%; 66) hypertensive disorders (17.5%; 14). preterm delivery (39.2%; 20/51) oligohydramnios (31.3%; 25). A (36.3%) foetal documented, stillbirth eight abortions.This is first describe behaviour women. Anaemia, pregnancy, oligohydramnios, low birth weight this population

Language: Английский

Citations

4

Impacts of the COVID-19 pandemic on access to HIV and reproductive health care among women living with HIV (WLHIV) in Western Kenya: A mixed methods analysis DOI Creative Commons
Caitlin Bernard, Shukri A. Hassan, John Humphrey

et al.

Frontiers in Global Women s Health, Journal Year: 2022, Volume and Issue: 3

Published: Dec. 12, 2022

The COVID-19 pandemic has impacted access to health services. Our objective was understand the pandemic's impact on HIV, pregnancy, and family planning (FP) care among women living with HIV (WLHIV).

Language: Английский

Citations

4

Characteristics of the pregnancy and labour course in women who underwent COVID-19 during pregnancy DOI

Elvira Shukenova,

Meilė Minkauskienė,

Nurzhamal Dzhardemalieva

et al.

Journal of Perinatal Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

Abstract Objectives This study aims to analyze the impact of COVID-19 on pregnancy and labor, focusing its effects maternal child health. The research explores relationships between coronavirus infection clinical laboratory parameters, as well risks complications adverse birth outcomes. Methods involved 60 pregnant women diagnosed with COVID-19. A comprehensive evaluation indicators was conducted, employing correlation, regression, logistic analyses determine risk factors. Results There a strong inverse correlation carbon dioxide levels haematocrit (−0.76), direct blood pH partial pressure oxygen (0.73). associated increased preterm labor (OR=1.82), stillbirth (OR=2.11), pre-eclampsia (OR=1.46), foetal distress. Multivariate analysis revealed 200 g reduction in neonatal weight higher hospitalisation (OR=1.8), postpartum hemorrhage (OR=2.3), delivery (OR=2.5). Comorbid conditions such cardiovascular abnormalities, diabetes, obesity, thrombophilias exacerbated complications, including pre-eclampsia, respiratory distress syndrome, venous thromboembolism. Conclusions increases likelihood outcomes, especially comorbidities. These findings highlight need for preventive strategies management protocols during future outbreaks, emphasizing importance further this field.

Language: Английский

Citations

0

Association Between COVID-19 During Pregnancy and Preterm Birth by Trimester of Infection: A Retrospective Cohort Study Using Longitudinal Social Media Data DOI Creative Commons
Ari Z. Klein, Shriya Kunatharaju, Su Golder

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 21, 2023

Abstract Background Preterm birth, defined as birth at <37 weeks of gestation, is the leading cause neonatal death globally and, together with low birthweight, second infant mortality in United States. There mounting evidence that COVID-19 infection during pregnancy associated an increased risk preterm birth; however, data remain limited by trimester infection. The ability to study earlier stages has been available sources data. objective this was use self-reports large-scale, longitudinal social media assess association between and birth. Methods In retrospective cohort study, we used natural language processing machine learning, followed manual validation, identify pregnant Twitter users search their collection publicly tweets for reports subsequently, a or term (i.e., gestational age ≥37 weeks) outcome. Among who reported on Twitter, also identified 1:1 age-matched control group, consisting due date prior January 1, 2020—that is, without pregnancy. We calculated odds ratios (ORs) 95% confidence intervals (CIs) compare overall rates pregnancies timing infection: first (weeks 1-13), 14-27), third 28-36). Results Through August 2022, 298 pregnancy, outcome, maternal age: 94 (31.5%) first-trimester infection, 110 (36.9%) second-trimester 95 (31.9%) third-trimester total, 26 (8.8%) these birth: 8 (8.5%) were infected trimester, 7 (6.4%) 12 (12.6%) trimester. 13 (4.4%) Overall, significantly higher compared those (OR 2.1, CI 1.06-4.16). particular, 3.17, 1.39-7.21). Conclusion results our suggest particularly

Language: Английский

Citations

1

WITHDRAWN: COVID-19 not hypertension or diabetes increases the risk of preeclampsia among a high-risk population DOI Open Access

Rachael Morris,

Ahmed S. Z. Moustafa, Wondwosen Kassahun‐Yimer

et al.

Pregnancy Hypertension, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 1, 2023

Language: Английский

Citations

0

Maternal, Fetal and Neonatal Outcomes in Pregnant Women with COVID-19: A Case-Control Study DOI
Mahtab Sattari, Banafshe Samari,

Rezvanehsadat Beheshti

et al.

Current Women s Health Reviews, Journal Year: 2023, Volume and Issue: 20(1)

Published: Feb. 1, 2023

Background: COVID-19 is an emerging, highly contagious disease caused by the SARSCoV- 2 virus. Pregnant women appear to be at greater risk for infection and complications. Considering importance of maternal fetal healthcare, this study aims evaluate some maternal, fetal, neonatal outcomes in pregnant with COVID-19. Methods: gestational age 20 weeks or more were recruited divided into two groups: cases (those infection) controls without infection). Maternal complications during current pregnancy, delivery factors, fetal/neonatal recorded compared between groups. Results: was associated need emergency cesarean surgery (p = 0.005), preterm labor 0.017), NICU admission newborns (OR 0.05, p 0.000). Also, high rates vertical transmission observed cases. Conclusion: could a range both mother her newborn. The rate also higher than previously reported literature. Further studies are required phenomenon.

Language: Английский

Citations

0

A critical review of COVID-19 course and vaccination in dermatology patients on immunomodulatory/biologic therapy: recommendations should not differ between non-pregnant and pregnant individuals DOI Creative Commons
Tassahil Messas, Rachel Lim,

Laura Burns

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 2, 2023

COVID-19 can have detrimental effects on immunosuppressed patients. Here, we evaluate the evidence regarding continuing immunomodulatory/biologic (IMBI) therapy in pregnant dermatology patients during pandemic. Also, discuss risks of vaccination IMBI therapy. As indicated this review, pandemic, there is no compelling reason for treating them differently than non-pregnant. The body indicates that mRNA vaccines are safe pregnancy. Studies rheumatology patients, a group overlaps significantly with group, provided essential findings. non-pregnant patient was not associated mortality (except rituximab), and pregnancy improved obstetric outcomes compared to unvaccinated patient. Based data, it be stated after weighing benefit–risk profile available vaccines, recommendation speaks favor vaccination. vaccine recommendations should differ from those their counterparts.

Language: Английский

Citations

0

Prenatal Covid-19 on Toddler Development DOI Creative Commons

Seri Pasongli,

Budu Budu,

Mardiana Ahmad

et al.

JURNAL INFO KESEHATAN, Journal Year: 2023, Volume and Issue: 21(2), P. 341 - 349

Published: June 30, 2023

Along with the spread of COVID-19 pandemic, there has been an increase in reports confirmed cases pregnant women COVID-19. Exposure to virus pregnancy can affect fetus and result long-term vulnerability abnormalities child's brain development. This study aimed determine impact prenatal Covid-19 on development toddlers. The research method uses observational cross-sectional analysis. Secondary data mothers were obtained from Prof. RD Kandou General Hospital, Wolter Monginsidi Manado Adventist Hospital. Primary toddler using KPSP Development Questionnaire instrument 10 Community Health Centers City a total 92 respondents for two, 46 born during period toddlers who not have period. results showed that was no significant effect p-value 0.562 impaired gross motor, fine socialization, independence, speech, language Based it be concluded both are at risk experiencing growth disturbances, especially pandemic because could effects occur infants exposed prenatal/intrauterine

Language: Английский

Citations

0