Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization DOI Creative Commons
Yeon Mi Hwang, Samantha N. Piekos, Alison G. Paquette

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 25, 2024

Pregnant women are significantly underrepresented in clinical trials, yet most of them take medication during pregnancy despite the limited safety data. The objective this study was to characterize use and apply propensity score matching method at scale on patient records accelerate prioritize drug effect signal detection associated with risk preterm birth other adverse outcomes.

Language: Английский

Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats DOI
Fengjiao Liu,

Yunlong Jia,

Liwei Zhao

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 984, P. 177063 - 177063

Published: Oct. 18, 2024

Language: Английский

Citations

3
Detection of Drug Effect Signals Associated with Adverse Pregnancy Outcomes Using Propensity Score Matching at Scale DOI Creative Commons
Yeon Mi Hwang, Samantha N. Piekos, Qi Wei

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 24, 2024

ABSTRACT Objective We applied propensity score matching method at scale on patient records to confirm signals of known drug effects preterm birth and detect previously unidentified potential effects. Materials Methods This was a retrospective study women who had continuity care Providence St. Joseph Health (PSJH) both before after pregnancy delivered live births between 2013/01/01 2022/12/31 (n=365,075). Our exposures interest were all outpatient medications prescribed during pregnancy. limited our analyses medication that met the minimal sample size (n=600). The primary outcome birth. Secondary outcomes small for gestational age low weight. used evaluate risk these adverse associated with exposure adjusting demographics, characteristics, comorbidities. Results total prescription rate increased from 58.5% 75.3% ( P <0.0001) 2013 2022. prevalence 7.7%. 175 out 1329 prenatally minimum size. identified 58 statistically significantly (P≤0.1; decreased: 12, increased: 46). Discussion narrowed down showed significant association even addressing numerous covariates through matching. Conclusion data-driven approach demonstrated multiple testable hypotheses in pharmacology can be prioritized scale, laying foundation application other outcomes.

Language: Английский

Citations

0
Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization DOI Creative Commons
Yeon Mi Hwang, Samantha N. Piekos, Alison G. Paquette

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 25, 2024

Pregnant women are significantly underrepresented in clinical trials, yet most of them take medication during pregnancy despite the limited safety data. The objective this study was to characterize use and apply propensity score matching method at scale on patient records accelerate prioritize drug effect signal detection associated with risk preterm birth other adverse outcomes.

Language: Английский

Citations

0