Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 720 - 720
Published: April 14, 2025
The gut microbiota has emerged as a crucial player in cardiovascular diseases, including heart failure (HF). Recent studies have highlighted the bidirectional interaction between and heart, often referred to gut–heart axis. Dysbiosis, characterized by alterations microbial composition function, been linked systemic inflammation, metabolic disturbances, impaired homeostasis. This review explores mechanisms through which influences HF, metabolite production, inflammatory pathways, endothelial dysfunction, hormonal modulation, fluid retention, sodium absorption. potential therapeutic implications of modulation diet, probiotics, pharmacological interventions are also discussed. Understanding these could pave way for novel diagnostic strategies management HF. Future research should focus on longitudinal establish causality development personalized microbiota-based interventions.
Language: Английский