Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

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Interplay among Oxidative Stress, Autophagy, and the Endocannabinoid System in Neurodegenerative Diseases: Role of the Nrf2- p62/SQSTM1 Pathway and Nutraceutical Activation

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 6868 - 6884

Published: July 2, 2024

The onset of neurodegenerative diseases involves a complex interplay pathological mechanisms, including protein aggregation, oxidative stress, and impaired autophagy. This review focuses on the intricate connection between stress autophagy in disorders, highlighting as pivotal disease pathogenesis. Reactive oxygen species (ROS) play dual roles cellular homeostasis regulation, with disruptions redox signaling contributing to neurodegeneration. activation Nrf2 pathway represents critical antioxidant mechanism, while maintains by degrading altered cell components. interaction among p62/SQSTM1, Nrf2, Keap1 forms regulatory essential for response, whose dysregulation leads aggregate accumulation. Targeting Nrf2-p62/SQSTM1 holds promise therapeutic intervention, mitigating preserving functions. Additionally, this explores potential synergy endocannabinoid system neuroprotection. Further research is needed elucidate involved molecular mechanisms develop effective strategies against

Language: Английский

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Redox Homeostasis, Gut Microbiota, and Epigenetics in Neurodegenerative Diseases: A Systematic Review

Antioxidants, Journal Year: 2024, Volume and Issue: 13(9), P. 1062 - 1062

Published: Aug. 30, 2024

Neurodegenerative diseases encompass a spectrum of disorders marked by the progressive degeneration structure and function nervous system. These conditions, including Parkinson's disease (PD), Alzheimer's (AD), Huntington's (HD), Amyotrophic lateral sclerosis (ALS), Multiple (MS), often lead to severe cognitive motor deficits. A critical component neurodegenerative pathologies is imbalance between pro-oxidant antioxidant mechanisms, culminating in oxidative stress. The brain's high oxygen consumption lipid-rich environment make it particularly vulnerable damage. Pro-oxidants such as reactive nitrogen species (RNS) (ROS) are continuously generated during normal metabolism, counteracted enzymatic non-enzymatic defenses. In diseases, this balance disrupted, leading neuronal This systematic review explores roles stress, gut microbiota, epigenetic modifications aiming elucidate interplay these factors identify potential therapeutic strategies. We conducted comprehensive search articles published 2024 across major databases, focusing on studies examining relationships redox homeostasis, changes neurodegeneration. total 161 were included, comprising clinical trials, observational studies, experimental research. Our findings reveal that stress plays central role pathogenesis with microbiota composition significantly influencing balance. Specific bacterial taxa markers identified modulators suggesting novel avenues for intervention. Moreover, recent evidence from human animal supports emerging concept targeting homeostasis through therapies. Future research should focus validating targets settings exploring personalized medicine strategies based individual profiles.

Language: Английский

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Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive

Language: Английский

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Neuroprotective Effect of Perillyl alcohol in Sporadic Alzheimer’s disease in Rats

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177558 - 177558

Published: April 1, 2025

Language: Английский

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Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer’s Disease Induced by Amyloid Beta 1–42 Peptide

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 543 - 543

Published: April 7, 2025

The onset of Alzheimer's disease (AD) is attributed to widespread amyloid beta (Aβ) plaque accumulation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. However, the underlying mechanism AD remains unclear, no curative treatment currently exists. aim was investigate effect thymoquinone by suppressing RAGE/NOX4 pathway in AD. Mice (n = 60) were divided into five groups, an experimental model induced Aβ1-42 peptide established two groups. We also administered 5 mg/kg (TMQ) mice for its properties slow or treat neurodegeneration Behavioral tests memory emotional states, micro-computed tomography (Micro CT) assess brain volume, ELISA measure malondialdehyde (MDA) levels, hematoxylin eosin staining (H&E) evaluate neuronal degeneration used. Immunohistochemical (IHC), Western blot (WB), real-time polymerase chain reaction (PCR) methods used inhibitory TMQ on a receptor advanced glycation end products (RAGE)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) signaling results showed that may have ameliorative effects memory, spatial learning, learning ability, anxiety has antioxidative decreasing MDA levels ELSIA method (p < 0.05). There marked increase compared other groups concluded could ameliorate H&E suppress IHC WB analysis. be therapeutic reducing AB expression level analysis Real-time PCR APP 0.05), RAGE, NOX4 0.05) gene expressions reduced TMQ. In conclusion, high potential effective preventive strategy can developed with more comprehensive studies

Language: Английский

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Exploring Oxidative Stress in Disease and Its Connection with Adenosine

Oxygen, Journal Year: 2024, Volume and Issue: 4(3), P. 325 - 337

Published: Aug. 19, 2024

Oxidative stress, characterized by an imbalance between the production of reactive oxygen species and body’s antioxidant defenses, plays important role in pathogenesis various health conditions, including cancer neurological disorders. For example, excessive ROS can lead to mutations, genomic instability, uncontrolled cell proliferation cancer. In disorders, oxidative stress contributes neuronal damage, inflammation, progression diseases such as Alzheimer’s Parkinson’s diseases. Adenosine, a nucleoside involved energy transfer signal transduction, is crucial maintaining cellular homeostasis. Its extends modulating stress. Adenosine receptors are implicated physiological processes pathophysiology The interplay adenosine signaling complex critical. modulate responses, providing therapeutic potential for conditions where key player. Understanding this connection opens up avenues novel strategies targeting mitigate damage.

Language: Английский

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Insights into Catechin–Copper Complex Structure and Biologic Activity Modulation

Molecules, Journal Year: 2024, Volume and Issue: 29(20), P. 4969 - 4969

Published: Oct. 21, 2024

Compounds of natural origin found in varying quantities plant-based products constitute a highly significant category, possessing structural significance as well the capacity to regulate oxidative processes. The activity these compounds may be modulated by composition biological environment which they operate, pH environment, or presence metal cations plants plant extracts. A successful complexation reaction was mainly confirmed FT-IR, observing shift from original transmittance catechin bonds, especially O-H ones. This work shows synthetic methodology and optimization process that took place synthesize catechin-copper complex, demonstrated antioxidant activity. It tested for iron chelation ability, hydroxyl radicals, inhibition lipoxygenase (15-LOX). An antidiabetic assay performed determining alpha-amylase alpha-glucosidase, finding synthesized complex had similar inhibitory potential pure catechin. antibacterial tests showed results against

Language: Английский

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Efficiency of Water Kumquat (Fortunella margarita) Extracts Against Hepatotoxicity Induced by Carbendazim in Vitro and In Vivo

Current Research in Nutrition and Food Science Journal, Journal Year: 2024, Volume and Issue: 12(3), P. 1389 - 1408

Published: Dec. 15, 2024

Objective: The study aims to evaluate the efficiency of water kumquat (Fortunella margarita) extracts in mitigating hepatotoxicity induced by carbendazim (CBZ), a broad-spectrum fungicide, both vitro and vivo. Methods: In vitro, HepG2 liver cancer cells were exposed CBZ determine half-maximal inhibitory concentration (IC50) assess protective effects extracts. vivo, 48 healthy male albino Sprague Dawley rats divided into two main groups: negative control group intoxication group. was further subdivided receive varying concentrations hot or cold Liver functions evaluated through biochemical assays, while histopathological examinations assessed tissue damage. Results: Kumquat exhibited significant hepatoprotective effects. improved cell viability reduced oxidative stress markers compared CBZ-treated cells. treatment with led levels enzymes, antioxidant status, minimized damage CBZ-exposed rats. dose-dependent, higher showing more effectiveness benefits. Conclusion: demonstrate considerable potential protecting against CBZ-induced toxicity. These investigations suggest that could serve as natural therapeutic option for preventing caused pesticide exposure.

Language: Английский

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