Synthesis, Characterization, and Evaluation of the Antifungal Properties of 3-Indolyl-3-Hydroxy Oxindole Derivatives Against Plant Pathogenic Fungi DOI Creative Commons
Zhi-Qiang Bai,

Kunrong Dang,

Jinrui Tang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1079 - 1079

Published: Feb. 26, 2025

To discover novel fungicides with good inhibitory effects on plant fungal diseases, twenty-five 3-indolyl-3-hydroxy oxindole derivatives (3a-3y) were synthesized. These newly characterized by NMR and HRMS. Their antifungal activities against five pathogenic fungi assessed in vitro. Most of the compounds exhibited moderate to excellent fungi. Notably, 3t, 3u, 3v, 3w displayed remarkable broad-spectrum comparable or superior those carvacrol (CA) phenazine-1-carboxylic acid (PCA). Among them, compound 3u most activity Rhizoctonia solani Kühn (R. solani), an EC50 3.44 mg/L, which was CA (7.38 mg/L) PCA (11.62 mg/L). Preliminary structure-activity relationship (SAR) results indicated that introduction I, Cl, Br substituents at position 5 3-hydroxy-2-oxindole indole rings is crucial for exhibit activity. The vivo assay showed has curative R. solani. current suggest these are capable serving as promising lead compounds.

Language: Английский

Synthesis, Characterization, and Evaluation of the Antifungal Properties of 3-Indolyl-3-Hydroxy Oxindole Derivatives Against Plant Pathogenic Fungi DOI Creative Commons
Zhi-Qiang Bai,

Kunrong Dang,

Jinrui Tang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1079 - 1079

Published: Feb. 26, 2025

To discover novel fungicides with good inhibitory effects on plant fungal diseases, twenty-five 3-indolyl-3-hydroxy oxindole derivatives (3a-3y) were synthesized. These newly characterized by NMR and HRMS. Their antifungal activities against five pathogenic fungi assessed in vitro. Most of the compounds exhibited moderate to excellent fungi. Notably, 3t, 3u, 3v, 3w displayed remarkable broad-spectrum comparable or superior those carvacrol (CA) phenazine-1-carboxylic acid (PCA). Among them, compound 3u most activity Rhizoctonia solani Kühn (R. solani), an EC50 3.44 mg/L, which was CA (7.38 mg/L) PCA (11.62 mg/L). Preliminary structure-activity relationship (SAR) results indicated that introduction I, Cl, Br substituents at position 5 3-hydroxy-2-oxindole indole rings is crucial for exhibit activity. The vivo assay showed has curative R. solani. current suggest these are capable serving as promising lead compounds.

Language: Английский

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