<i>Escherichia </i><i>coli</i>: Research Progress on Drug Resistance Mechanisms and Emerging Treatment Strategies DOI

利君 秦

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 240 - 252

Published: Jan. 1, 2025

The Antimicrobial Peptide D-CONGA-Q7 Eradicates Drug-Resistant E. coli by Disrupting Bacterial Cell Membranes DOI Creative Commons

Zonghan Jiang,

Leisheng Sun, Yuanyuan Li

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 226 - 226

Published: Feb. 21, 2025

Escherichia coli (E. coli) is a zoonotic bacterium widespread in the environment, highly transmissible, and responsible for significant economic losses millions of cases illness annually. The rise multidrug-resistant (MDR) strains has rendered last-line antibiotics such as polymyxin meropenem ineffective, making development new urgent. Although D-CONGA-Q7 broad-spectrum bactericidal activity, its underlying mechanism remains poorly understood. In this study, we used vitro vivo experiments to demonstrate that effectively kills both antibiotic-sensitive E. coli. disrupts cell membranes Gram-negative bacteria, treatment strain LN175 with resulted up-regulation Mlac gene, suggesting may interact phospholipids membrane. Furthermore, treating K88-induced bacterial enteritis small intestine, significantly reduced intestinal inflammation. conclusion, study provides novel approach combat drug-resistant

Language: Английский

Citations

0
LPS-Enriched Interaction Drives Spectrum Conversion in Antimicrobial Peptides: Design and Optimization of AA16 Derivatives for Targeting Gram-Negative Bacteria DOI

Wanyang Xiao,

Ruize Sun,

Jenny W. H. Lou

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117462 - 117462

Published: Feb. 28, 2025

Language: Английский

Citations

0
Synthesis, Molecular modelling, and antimicrobial activity of new triazole-thiophene compounds DOI
Matokah M. Abualnaja,

Shaker T. Alsharif,

Alaa M. Alqahtani

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141898 - 141898

Published: Feb. 1, 2025

Language: Английский

Citations

0
Therapeutic effect of pH responsive Magainin II modified azithromycin plus curcumin micelles in different depth models of MRSA infection DOI Creative Commons
Lu Zhang,

Rui-bo Guo,

Liu Yang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for serious infections in humans. The overuse of antibiotics has led to the evolution resistance genes bacteria. This study aimed develop pH-responsive micelle, loaded with therapy drugs and modified antimicrobial peptides, treat drug-resistant bacterial at varying depths. micelles containing azithromycin curcumin, Magainin II, were prepared using thin-film dispersion method. physicochemical properties characterized, their targeting therapeutic effects on investigated both vivo vitro across various demonstrated excellent infection sites released response degradation disease site. combination curcumin effectively mitigated through multiple mechanisms, enhancing antibacterial effect while reducing required dosage associated toxicity. In models depths—skin, muscle, lungs—the exhibited strong antibacterial, anti-biofilm, anti-inflammatory low These findings provide promising strategy addressing infections.

Language: Английский

Citations

0
<i>Escherichia </i><i>coli</i>: Research Progress on Drug Resistance Mechanisms and Emerging Treatment Strategies DOI

利君 秦

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 240 - 252

Published: Jan. 1, 2025

Citations

0