Penilumamide, a novel SIRT1 activator, protects UVB-induced photodamages in HaCaT cells DOI Creative Commons
Ji Won Park, Jae Hyeon Park, Haeun Lee

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Aug. 6, 2024

Ultraviolet-B (UVB) radiation is a major physical factor that induces structural changes in human skin. The aim of this study was to determine whether the novel silent information regulator 1 (sirtuin SIRT1) protein activator, penilumamide, exerted any protective effects against UVB-induced skin damage using HaCaT keratinocytes as model. Enzymatic assays were performed SIRT1-activating ability which compared with resveratrol, potent natural product SIRT1 activator antioxidant and anti-inflammatory properties. Penilumamide markedly activated enzyme activity resveratrol. To further investigate effect penilumamide cytotoxicity, cells pretreated (10 μM) for 24 hr followed by irradiation UVB (40 mJ/cm2). mJ/cm2) significantly reduced cell viability time-dependent manner, whereas pretreatment blocked effect. Further, decreased levels intracellular reactive oxygen species (ROS) generated cells. Pretreatment also prevented irradiation-induced mitochondrial membrane potential (ΔΨm). In addition, expression pro-inflammatory cytokines, interleukin (IL)-6, IL-8, IL-10 phosphorylation nuclear factor-kB (NF-kB). These results indicate protects from inflammation. Taken together data demonstrate ROS generation Therefore, may be considered used new protect keratinocyte damage.

Language: Английский

Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy DOI Creative Commons
Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Language: Английский

Citations

3
Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties DOI Creative Commons

Basma Es-Sai,

Hicham Wahnou, S. Benayad

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 653 - 653

Published: Feb. 1, 2025

Gamma-tocopherol (γ-tocopherol), a major isoform of vitamin E, exhibits potent antioxidant, anti-inflammatory, and anticancer properties, making it promising therapeutic candidate for treating oxidative stress-related diseases. Unlike other tocopherol isoforms, γ-tocopherol effectively neutralizes reactive oxygen species (ROS) nitrogen (RNS), providing robust cellular protection against damage lipid peroxidation. Its anti-inflammatory effects are mediated through the modulation pathways involving cyclooxygenase-2 (COX-2) tumor necrosis factor-alpha (TNF-α), reducing chronic inflammation its associated risks. In cancer therapy, demonstrates multifaceted activity, including inhibition growth, induction apoptosis, suppression angiogenesis, with significant efficacy observed in cancers such as prostate, lung, colon. Preclinical clinical studies support mitigating stress, inflammation, progression, excellent tolerance at physiological levels. However, high doses necessitate careful evaluation to minimize adverse effects. This review consolidates current knowledge on γ-tocopherol’s biological activities implications, underscoring importance natural compound managing cancer. As perspective, advancements nanoformulation technology could enhance bioavailability, stability, targeted delivery, offering potential optimize application future.

Language: Английский

Citations

1
Integrating ADMET, enrichment analysis, and molecular docking approach to elucidate the mechanism of Artemisia herba alba for the treatment of inflammatory bowel disease-associated arthritis DOI
Hicham Wahnou, Fouzia Hmimid, Ahmed Errami

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(20), P. 836 - 854

Published: July 19, 2024

Inflammatory Bowel Disease-Associated Arthritis (IBD-associated arthritis) poses a significant challenge, intertwining the complexities of both inflammatory bowel disease (IBD) and arthritis, significantly compromising patient quality life. While existing medications offer relief, these drugs often initiate adverse effects, necessitating requirement for safer therapeutic alternatives.

Language: Английский

Citations

5
Vernonia amygdalina Delile and cancer: a comprehensive review of its chemopreventive mechanisms and efficacy DOI Creative Commons
Martin Ndayambaje, Thierry Habyarimana,

Theogene Niyonsaba

et al.

Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)

Published: Jan. 30, 2025

Language: Английский

Citations

0
Antioxidant capacity, acute and sub-acute oral toxicity, and in vivo anti-inflammatory effects of Tetradenia riparia hydroalcoholic extract DOI
Martin Ndayambaje, Thierry Habyarimana, Hicham Wahnou

et al.

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 23, 2025

Tetradenia riparia (T. riparia) is a medicinal plant native to sub-Saharan Africa, traditionally used but has limited in vivo scientific validation. This study evaluated its antioxidant, toxicity, and anti-inflammatory effects using toxicity tests, paw edema, air pouch models, vascular permeability assessment. Additionally, qualitative phytochemical analysis quantitative measurements of total polyphenolic flavonoid content were conducted. In vitro assays revealed significant concentrations compounds, demonstrating notable radical scavenging activities DPPH, phosphomolybdate, FRAP assays. studies demonstrated that T. extract showed no indications acute or sub-acute oral even when administered at the highest tested dosage 5000 mg/kg body weight (LD50 > mg/kg). Toxicity assessments confirmed safety, showing fatalities, organ damage as evidenced by histopathological analysis, substantial adverse on most hematological biochemical parameters. The hydroalcoholic effect increased with dosage. inhibition percentage edema was high 3 hours, reaching 39.13 ± 8.78%. Nitric oxide (NO) doses 0.5 g/kg 1 recorded 36.09 2.13% 49.96 5.41%, respectively. Regarding permeability, significantly reduced dye leakage (p < 0.05 p 0.001), percentages 61.57% 75.25% g/kg, These findings highlight promising potential treatment for inflammatory disorders. conclusion, identified which are believed be responsible pharmacological observed. Further needed investigate chronic consumption long-term isolate bioactive understand their mechanisms, ensure comprehensive safety profiles drug development, elucidate mechanism.

Language: Английский

Citations

0
Pharmacological insights into Laurus nobilis: HPLC profiling and evaluation of its anti-Toxoplasma, antioxidant, and anti-hemolytic properties DOI
Othman El Faqer, Ismail Elkoraichi, Mounia Latif

et al.

Biochemical Systematics and Ecology, Journal Year: 2024, Volume and Issue: 117, P. 104891 - 104891

Published: Sept. 3, 2024

Language: Английский

Citations

3
Penilumamide, a novel SIRT1 activator, protects UVB-induced photodamages in HaCaT cells DOI Creative Commons
Ji Won Park, Jae Hyeon Park, Haeun Lee

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: Aug. 6, 2024

Ultraviolet-B (UVB) radiation is a major physical factor that induces structural changes in human skin. The aim of this study was to determine whether the novel silent information regulator 1 (sirtuin SIRT1) protein activator, penilumamide, exerted any protective effects against UVB-induced skin damage using HaCaT keratinocytes as model. Enzymatic assays were performed SIRT1-activating ability which compared with resveratrol, potent natural product SIRT1 activator antioxidant and anti-inflammatory properties. Penilumamide markedly activated enzyme activity resveratrol. To further investigate effect penilumamide cytotoxicity, cells pretreated (10 μM) for 24 hr followed by irradiation UVB (40 mJ/cm2). mJ/cm2) significantly reduced cell viability time-dependent manner, whereas pretreatment blocked effect. Further, decreased levels intracellular reactive oxygen species (ROS) generated cells. Pretreatment also prevented irradiation-induced mitochondrial membrane potential (ΔΨm). In addition, expression pro-inflammatory cytokines, interleukin (IL)-6, IL-8, IL-10 phosphorylation nuclear factor-kB (NF-kB). These results indicate protects from inflammation. Taken together data demonstrate ROS generation Therefore, may be considered used new protect keratinocyte damage.

Language: Английский

Citations

1