Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy DOI
Khusbu Dwivedi, Ankit Sahoo, Waleed Hassan Almalki

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Dec. 20, 2024

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations high metabolism, poor absorption, dosage requirements. Challenges the large-scale isolation phytoactive compounds, solubility, bioavailability, targeting limit their development. Recent developments, including carbohydrate, lipid, protein-based nanoparticles, have enhanced treatment by improving bioavailability targeted delivery polyphenols, alkaloids, sulfur-containing flavonoids, terpenes. Despite advancements, clinical application faces hurdles inconsistent immune responses. This article discusses phytoactive-loaded nanoformulations management, highlighting delivery, unmet needs, challenges. Further research is needed overcome these fully understand potential management.

Language: Английский

Molecular docking analyses on the chemical profile and antioxidant potential of Cakile maritima using GC–MS and HPLC DOI Creative Commons
Erdi Can Aytar, Emine İncilay Torunoğlu,

Abidin Gümrükçüoğlu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 8, 2025

Language: Английский

Citations

0
Inhibitory effects of corylin derived from aerial part of Pueraria lobata on melanin synthesis and potential applications in skin whitening and photoaging management DOI Creative Commons

BoYoon Chang,

SungYeon Kim

Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 27, 2025

Abstract Purpose This study aimed to investigate the potential of corylin, a bioactive compound isolated from aerial part Pueraria lobata , as novel skin-whitening agent. Specifically, research sought evaluate its effects on melanin synthesis, understand underlying mechanisms, and validate efficacy in mitigating hyperpigmentation. Methods Bioactive was through systematic fractionation process involving activated carbon pigment removal, sequential solvent extraction, resin-based chromatography. It shown inhibit synthesis by targeting tyrosinase activation modulating key signaling pathways. Its reducing production validated cellular assays UVB-stimulated 3D human skin model, highlighting Results Through fractionation, identified which reduced content activity without cytotoxicity, modulated pathways downregulate MITF melanogenic enzymes, inhibited α-glucosidase, disrupted glycosylation. In it effectively decreased production, confirming mitigate Conclusion Corylin is promising candidate for applications, hyperpigmentation multiple stages including enzymatic regulatory Further clinical studies are needed confirm safety therapeutic dermatological use. Graphical

Language: Английский

Citations

0
Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy DOI
Khusbu Dwivedi, Ankit Sahoo, Waleed Hassan Almalki

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Dec. 20, 2024

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations high metabolism, poor absorption, dosage requirements. Challenges the large-scale isolation phytoactive compounds, solubility, bioavailability, targeting limit their development. Recent developments, including carbohydrate, lipid, protein-based nanoparticles, have enhanced treatment by improving bioavailability targeted delivery polyphenols, alkaloids, sulfur-containing flavonoids, terpenes. Despite advancements, clinical application faces hurdles inconsistent immune responses. This article discusses phytoactive-loaded nanoformulations management, highlighting delivery, unmet needs, challenges. Further research is needed overcome these fully understand potential management.

Language: Английский

Citations

1