Magnetic resonance imaging bias field correction improves tumor prognostic evaluation after transcatheter arterial chemoembolization for liver cancer DOI
Peng Liu,

Junbiao Li,

Yong Wang

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(4)

Published: March 29, 2025

BACKGROUND Transcatheter arterial chemoembolization (TACE) is a key treatment approach for advanced invasive liver cancer (infiltrative hepatocellular carcinoma). However, its therapeutic response can be difficult to evaluate accurately using conventional two-dimensional imaging criteria due the tumor’s diffuse and multifocal growth pattern. Volumetric imaging, especially enhanced tumor volume (ETV), offers more comprehensive assessment. Nonetheless, bias field inhomogeneity in magnetic resonance (MRI) poses challenges, potentially skewing volumetric measurements undermining prognostic evaluation. AIM To investigate whether MRI correction enhances accuracy of assessment infiltrative carcinoma treated with TACE, analyze how this improved measurement impacts prediction. METHODS We retrospectively collected data from 105 patients who underwent TACE at Affiliated Hospital Xuzhou Medical University January 2020 2024. The N4 algorithm was applied process images, ETV before after calculated. were compared, their relationship patient prognosis analyzed. A Cox proportional hazards model used factors, Martingale residual analysis determining optimal cutoff value, followed by survival analysis. RESULTS Bias significantly affected measurements, corrected baseline mean (505.235 cm³) being lower than (825.632 cm³, P < 0.001). showed that hazard ratio (HR) (HR = 1.165, 95%CI: 1.069-1.268) higher 1.063, 1.031-1.095). Using 412 cm³ as cutoff, group 415 had longer median time compared ≥ (18.523 months vs 8.926 months, an reduction rate 41% better (17.862 9.235 0.006). Multivariate confirmed 0.412, 0.001), Child-Pugh classification 0.298, Barcelona Clinic Liver Cancer stage 0.578, 0.045) independent factors. CONCLUSION Volume based on improve evaluating efficacy cancer. serve indicators predicting prognosis, providing important reference developing individualized strategies.

Language: Английский

Magnetic resonance imaging bias field correction improves tumor prognostic evaluation after transcatheter arterial chemoembolization for liver cancer DOI
Peng Liu,

Junbiao Li,

Yong Wang

et al.

World Journal of Gastrointestinal Surgery, Journal Year: 2025, Volume and Issue: 17(4)

Published: March 29, 2025

BACKGROUND Transcatheter arterial chemoembolization (TACE) is a key treatment approach for advanced invasive liver cancer (infiltrative hepatocellular carcinoma). However, its therapeutic response can be difficult to evaluate accurately using conventional two-dimensional imaging criteria due the tumor’s diffuse and multifocal growth pattern. Volumetric imaging, especially enhanced tumor volume (ETV), offers more comprehensive assessment. Nonetheless, bias field inhomogeneity in magnetic resonance (MRI) poses challenges, potentially skewing volumetric measurements undermining prognostic evaluation. AIM To investigate whether MRI correction enhances accuracy of assessment infiltrative carcinoma treated with TACE, analyze how this improved measurement impacts prediction. METHODS We retrospectively collected data from 105 patients who underwent TACE at Affiliated Hospital Xuzhou Medical University January 2020 2024. The N4 algorithm was applied process images, ETV before after calculated. were compared, their relationship patient prognosis analyzed. A Cox proportional hazards model used factors, Martingale residual analysis determining optimal cutoff value, followed by survival analysis. RESULTS Bias significantly affected measurements, corrected baseline mean (505.235 cm³) being lower than (825.632 cm³, P < 0.001). showed that hazard ratio (HR) (HR = 1.165, 95%CI: 1.069-1.268) higher 1.063, 1.031-1.095). Using 412 cm³ as cutoff, group 415 had longer median time compared ≥ (18.523 months vs 8.926 months, an reduction rate 41% better (17.862 9.235 0.006). Multivariate confirmed 0.412, 0.001), Child-Pugh classification 0.298, Barcelona Clinic Liver Cancer stage 0.578, 0.045) independent factors. CONCLUSION Volume based on improve evaluating efficacy cancer. serve indicators predicting prognosis, providing important reference developing individualized strategies.

Language: Английский

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