Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species (S. alata (L.) Roxb. and S. occidentalis (L.) Link) DOI Creative Commons
Sakina Yagi, Mehmet Veysi Çetiz, Gökhan Zengin

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 22, 2024

ABSTRACT Senna alata (L.) Roxb. and occidentalis Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed determine the phytoconstituents, antioxidant, enzyme inhibition, antimicrobial activities methanolic extract from leaves these two species. A total 75 phenolic compounds belonging dihydroxybenzoic acids, dihydroxycinnamic flavonoid C‐glycosides, O‐glycosides, aglycones, anthraquinone glycosides, aglycones were identified. Flavonoid C‐glycosides only found S. while sennosides A, B, C detected . In line with its higher flavonoids contents, exerted significantly ( p < 0.05) antiradical (2,2‐diphenyl‐1‐picrylhydrazy (DPPH) = 58.36 mg trolox equivalent (TE)/g; 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) 118.86 TE/g), ions reducing (cupric antioxidant capacity (CUPRAC) 93.85 TE/g; ferric power (FRAP) 50.42 (1.39 mmol TE/g) than revealed inhibitory effect against butyrylcholinesterase (1.67 galantamine (GALAE)/g), tyrosinase (45.07 KAE/g) 45.07 kojic (KAE)/g), α‐glucosidase (0.73 acarbose (ACAE)/g), α‐amylase (2.95 ACAE/g) enzymes. Both species showed high antibacterial antifungal remarkable activity by Trichoderma viride (minimum inhibition concentration (MIC) 1 mg/mL), similar that Ketoconazole. utilized molecular docking, mechanics Poisson–Boltzmann surface area (MM/PBSA) free energy calculations, dynamics simulations evaluate binding interactions between glycosides various bacterial enzymes, including targets Escherichia coli Staphylococcus aureus findings suggest like sennoside chrysophanol exhibit strong affinities, stable interactions, potential as inhibitors, especially vital proteins such MurE 30S ribosome S3. conclusion, our underscore biopharmaceutical species, suggesting their significance sources bioactive agents for health‐related applications.

Language: Английский

Exploring the chemical constituents and biological activities of leaf and twig extracts of two Amygdalus species from Turkey’s flora: cell-free, in vitro and molecular docking approaches DOI
Gökhan Zengin, Sakina Yagi, Zoltán Cziáky

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105869 - 105869

Published: Jan. 1, 2025

Language: Английский

Citations

0
Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods DOI Creative Commons
Mehmet Cengiz Baloğlu, Lütfiye Yıldız Özer,

Buket Pirci

et al.

Food Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

ABSTRACT Liquidambar orientalis , the Anatolian sweetgum tree, is a relict and endemic species in Southwestern Turkey, traditionally used for therapeutic purposes. Our study comprehensively evaluated potential of L. extracts from its aerial parts to maximize bioactive compound extraction using methanol, ethyl acetate, water as solvents. The methanolic extract exhibited highest phenolic (73.04 ± 3.94 mg gallic acid equivalent [GAE]/g) flavonoid content (48.86 0.76 rutin [RE]/g), demonstrating superior antioxidant activity 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) (256.61 1.70 Trolox [TE]/g), 2,2′‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) (308.41 3.14 TE/g), cupric ion–reducing capacity (CUPRAC) (411.13 8.48 TE/g) assays. It also showed significant enzyme inhibition acetylcholinesterase (4.43 0.09 galanthamine [GALAE]/g), tyrosinase (149.16 1.14 kojic [KAE]/g), amylase (0.93 0.02 mmol acarbose [ACAE]/g), glucosidase (1.60 0.01 ACAE/g), suggesting applications neurodegenerative disease management, skincare, diabetes treatment. Furthermore, methanol displayed promising antimicrobial due compounds such chlorogenic methyl‐3‐ O ‐caffeoyl quinate. potent anticancer effects against lung cancer (A549) cells, with reductions cell viability induction autophagy. aqueous remarkable efficacy prostate (PC3) modulating apoptosis markers. Breast cells (MDA‐MB‐231) differential responses, acetate promoting extract–enhancing molecular docking dynamics simulations provided additional evidence supporting key phytochemicals particularly afzelin epigallocatechin, cancer‐related targets bacterial enzymes. Overall, this fills gap understanding inhibitory diverse extracts, highlighting multi‐targeted applications, therapy.

Language: Английский

Citations

0
Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies DOI Creative Commons
Muammer Bahşi, Simonetta Cristina Di Simone, Dimitrina Zheleva‐Dimitrova

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT This study investigates the phytochemical composition and biopharmacological potential of three Hypericum species ( H. scabrum , lysimachioides uniglandulosum ) from Turkey. Aqueous hydroalcoholic extracts were analyzed for their total phenolic content (TPC), flavonoid (TFC), individual components (by UHPLC–HRMS technique). Antioxidant activities investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, metal chelating assays. The inhibition effects tested on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, glucosidase examined. One hundred compounds identified in chemical composition, specific genus such as hyperoside, hypericin, pseudohypericin, detected. highest TPC was detected ethanol/water extract with 69.21 mg GAE/g. Furthermore, showed strongest free radical reducing effect. more active than water extracts. Neuroprotective assessments indicated downregulation COX‐2 NOS‐2 genes LPS‐stimulated mouse cortex models, alongside modulation SERT NET expression, suggesting reduced neuroinflammation enhanced neurotransmitter release. Molecular docking dynamics analyses highlighted strong binding interactions, especially NET_hyperoside NET_myricitrin complexes. results indicate significant therapeutic these extracts, supporting development natural agents against oxidative stress, neuroinflammation, related neurodegenerative diseases.

Language: Английский

Citations

0
Antioxidants: a comprehensive review DOI Creative Commons
İlhami Gülçın

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

Citations

0
Characterization of the chemical profiles and biological activities of Thesium bertramii Azn. Extracts using a combination of in vitro, in silico, and network pharmacology methods DOI
Eulogio J. Llorent‐Martínez,

Sakina Yagi,

Gokhan Zengin

et al.

Fitoterapia, Journal Year: 2024, Volume and Issue: 180, P. 106329 - 106329

Published: Dec. 5, 2024

Language: Английский

Citations

2
Novel Natural Candidates for Replacing Synthetic Additives in Nutraceutical and Pharmaceutical Areas: Two Senna Species (S. alata (L.) Roxb. and S. occidentalis (L.) Link) DOI Creative Commons
Sakina Yagi, Mehmet Veysi Çetiz, Gökhan Zengin

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 13(1)

Published: Dec. 22, 2024

ABSTRACT Senna alata (L.) Roxb. and occidentalis Link (family Fabaceae) are commonly used in different systems of traditional medicine to treat ailments. The present study was designed determine the phytoconstituents, antioxidant, enzyme inhibition, antimicrobial activities methanolic extract from leaves these two species. A total 75 phenolic compounds belonging dihydroxybenzoic acids, dihydroxycinnamic flavonoid C‐glycosides, O‐glycosides, aglycones, anthraquinone glycosides, aglycones were identified. Flavonoid C‐glycosides only found S. while sennosides A, B, C detected . In line with its higher flavonoids contents, exerted significantly ( p < 0.05) antiradical (2,2‐diphenyl‐1‐picrylhydrazy (DPPH) = 58.36 mg trolox equivalent (TE)/g; 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS) 118.86 TE/g), ions reducing (cupric antioxidant capacity (CUPRAC) 93.85 TE/g; ferric power (FRAP) 50.42 (1.39 mmol TE/g) than revealed inhibitory effect against butyrylcholinesterase (1.67 galantamine (GALAE)/g), tyrosinase (45.07 KAE/g) 45.07 kojic (KAE)/g), α‐glucosidase (0.73 acarbose (ACAE)/g), α‐amylase (2.95 ACAE/g) enzymes. Both species showed high antibacterial antifungal remarkable activity by Trichoderma viride (minimum inhibition concentration (MIC) 1 mg/mL), similar that Ketoconazole. utilized molecular docking, mechanics Poisson–Boltzmann surface area (MM/PBSA) free energy calculations, dynamics simulations evaluate binding interactions between glycosides various bacterial enzymes, including targets Escherichia coli Staphylococcus aureus findings suggest like sennoside chrysophanol exhibit strong affinities, stable interactions, potential as inhibitors, especially vital proteins such MurE 30S ribosome S3. conclusion, our underscore biopharmaceutical species, suggesting their significance sources bioactive agents for health‐related applications.

Language: Английский

Citations

2