Role of anoikis-related gene RAC3 in prognosis, immune microenvironment, and contribution to malignant behavior in vitro and in vivo of bladder urothelial carcinoma DOI Creative Commons

Yusong Zhou,

Shiwei Huang,

Bing Yang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 26, 2024

Anoikis disrupts the normal apoptotic process in cells, leading to abnormal proliferation and migration, thereby promoting tumor formation development. However, role of anoikis bladder urothelial carcinoma (BLCA) still requires further exploration.

Language: Английский

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases DOI Creative Commons

Chuan Xu,

Chaoyang Jiang, Zhihui Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Exosomes are nanoscale vesicles of cellular origin. One the main characteristics exosomes is their ability to carry a wide range biomolecules from parental cells, which important mediators intercellular communication and play an role in physiological pathological processes. have advantages biocompatibility, low immunogenicity, biodistribution. As researchers' understanding has increased, various strategies been proposed for use diagnosing treating diseases. Here, we provide overview biogenesis composition exosomes, describe relationship between disease progression, focus on as biomarkers early screening, monitoring, guiding therapy refractory diseases such tumors neurodegenerative We also summarize current applications especially engineered efficient drug delivery, targeted therapies, gene immune vaccines. Finally, challenges potential research directions clinical application discussed. In conclusion, emerging molecule that can be used diagnosis treatment diseases, combined with multidisciplinary innovative solutions, will applications.

Language: Английский

Citations

2
LncRNA NR2F2‐AS1 inhibits the progression of oral squamous cell carcinoma by mediating the miR‐32‐5p/SEMA3A axis DOI Creative Commons
Shi‐Yu Qin, Bo Li,

Ji‐Mu Liu

et al.

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 40(10), P. 877 - 889

Published: Aug. 23, 2024

Abstract Previous studies have supported a tumor‐suppressive role of semaphorin 3A (SEMA3A) in several tumors including oral squamous cell carcinoma (OSCC). However, in‐depth characterization the SEMA3A OSCC and underlying molecular mechanisms is lacking. Gene protein expressions were detected using quantitative real‐time PCR, western blot assay, immunohistochemistry. metastasis was evaluated Transwell angiogenesis human umbilical vein endothelial cells (HUVECs) determined tube formation assay. The interactions among molecules predicted bioinformatics analysis validated luciferase activity experiment RNA immunoprecipitation Pulmonary hematoxylin eosin staining after constructing lung tumor model mice. expression decreased its overexpression led to suppression epithelial‐mesenchymal transition (EMT), migration, invasion HUVECs. miR‐32‐5p identified as an upstream molecule long non‐coding NR2F2 antisense 1 (NR2F2‐AS1) gene miR‐32‐5p. Further experiments revealed that inhibitory effects NR2F2‐AS1 on EMT, cells, HUVECs well growth mice mediated via miR‐32‐5p/SEMA3A axis. To conclude, may attenuate suppress

Language: Английский

Citations

2
Bladder cancer: non-coding RNAs and exosomal non-coding RNAs DOI

Jingang Zhao,

Yangyang Ma,

Xiaodong Zheng

et al.

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(5)

Published: Aug. 31, 2024

Language: Английский

Citations

1
Proangiogenic potential of plasma exosomes from prostate cancer patients DOI
Chao Wang, Chuan Zhou, Dong Wang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111398 - 111398

Published: Sept. 13, 2024

Language: Английский

Citations

1
STAMBPL1 promotes triple-negative breast cancer angiogenesis by upregulating the transcription of GRHL3/HIF1α/VEGFA via FOXO1 DOI Creative Commons
Ceshi Chen, Huan Fang, Huichun Liang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Anti-angiogenesis is a crucial therapeutic strategy for triple-negative breast cancer (TNBC), but the current targeted drugs are insufficient to meet clinical requirements. Our study has discovered that silencing deubiquitinating enzyme STAMBPL1 can effectively inhibit growth and angiogenesis of TNBC xenografts in nude mice. promotes expression HIF1α/VEGFA through non-enzymatic-dependent mechanism. interacts with transcription factor FOXO1, which binds promoter GRHL3 gene, thereby positively regulating its transcription. Subsequently, GRHL3 HIF1α gene promote angiogenesis. Moreover, we have demonstrated combination FOXO1 inhibitor AS1842856 VEGFR Apatinib significantly inhibited transplanted tumors These findings indicate STAMBPL1/FOXO1/GRHL3/HIF1α/VEGFA axis provides potential targets TNBC.

Language: Английский

Citations

0
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer DOI Creative Commons
Huan Fang, Huichun Liang,

Chuanyu Yang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Abstract In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative and advanced breast cancer. Our previous research revealed that deubiquitinase STAMBPL1 enhances stability of MKP-1, thereby promoting cisplatin resistance in this study, we discovered could upregulate expression hypoxia-inducible factor HIF1α cancer cells. Therefore, investigated whether promotes tumor angiogenesis. We demonstrated increased HIF1A transcription a non-enzymatic manner, activating HIF1α/VEGFA signaling pathway to facilitate TNBC Through RNA-seq analysis, identified GRHL3 as downstream target responsible mediating transcription. Furthermore, regulates by interacting with FOXO1. These findings shed light on role mechanism pathogenesis cancer, offering novel targets avenues treatment

Language: Английский

Citations

0
Exploring the Role of MicroRNAs in Progesterone and Estrogen Receptor Expression in Endometriosis DOI Creative Commons

Jing-Xian Hon,

Norhazlina Abdul Wahab, Abdul Kadir Abdul Karim

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2218 - 2218

Published: Sept. 28, 2024

: Patients with endometriosis still respond poorly to progestins due progesterone resistance associated microRNAs (miRNAs). The aim of this study was investigate the expression selected miRNAs, estrogen receptor (ER)α, ERβ, (PR)-A and PR-B determine target genes upregulated miRNAs in endometriosis.

Language: Английский

Citations

0
New perspectives of exosomes in urologic malignancies - mainly focus on biomarkers and tumor microenvironment DOI
Hai Tang, Yizhi Liu,

Jingwei Ke

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155645 - 155645

Published: Oct. 19, 2024

Language: Английский

Citations

0
Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host? DOI Creative Commons
Jun Zou, Baisheng Xu,

Peiyue Luo

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 19, 2024

In recent years, the role of gut microbiota (GM) in bladder cancer has attracted significant attention. Research indicates that GM not only contributes to carcinogenesis but also influences efficacy adjuvant therapies for cancer. Despite this, interventions targeting have been widely employed prevention and treatment cancer, mainly due incomplete understanding complex interactions between host flora. Simultaneously, aberrantly expressed non-coding RNAs (ncRNAs) frequently associated with playing crucial roles processes such as cell proliferation, invasion, drug resistance. It is known regulation GM-mediated pathophysiological partly regulated through epigenetic pathways. At same time, ncRNAs are increasingly regarded signaling molecules involved regulation. Accordingly, this review analyzes closely related context occurrence treatment, summarizes their interaction cancer-related phenotypes. The aim delineate a regulatory network provide new perspective study

Language: Английский

Citations

0
STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer DOI Creative Commons
Huan Fang, Huichun Liang,

Chuanyu Yang

et al.

eLife, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

In the clinic, anti-tumor angiogenesis is commonly employed for treating recurrent, metastatic, drug-resistant triple-negative and advanced breast cancer. Our previous research revealed that deubiquitinase STAMBPL1 enhances stability of MKP-1, thereby promoting cisplatin resistance in this study, we discovered could upregulate expression hypoxia-inducible factor HIF1α cancer cells. Therefore, investigated whether promotes tumor angiogenesis. We demonstrated increased HIF1A transcription a non-enzymatic manner, activating HIF1α/VEGFA signaling pathway to facilitate TNBC Through RNA-seq analysis, identified GRHL3 as downstream target responsible mediating transcription. Furthermore, regulates by interacting with FOXO1. These findings shed light on role mechanism pathogenesis cancer, offering novel targets avenues treatment

Language: Английский

Citations

0