Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 483 - 503

Published: Jan. 1, 2025

Abstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part immunotherapy. However, improve efficacy therapy is currently major challenge. Nanomaterials show their unique advantages whole process. At present, nanomaterials have achieved significant accomplishments medical applications, particularly field cancer-targeted therapy, showing enormous potential. It confirmed can not only directly target CAFs, but also interact with microenvironment (TME) immune affect tumorigenesis. As for treatment, could enhance therapeutic effect many ways. Therefore, this review, we first summarized current understanding complex interactions between TME, cells, cells. Next, discussed common modern medicine respective impacts on tumors. Finally, focus application nano drug delivery system therapy. Keywords: cancer-associated fibroblasts, delivery, nanomedicine, immunotherapy

Language: Английский

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Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

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The hepatoprotective potential of tannic acid against doxorubicin‐induced hepatotoxicity: Insights into its antioxidative, anti‐inflammatory, and antiapoptotic mechanisms

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(8)

Published: Aug. 1, 2024

Abstract Doxorubicin (DOX), which is frequently used in cancer treatment, has limited clinical use due to adverse effects on healthy tissues, especially the liver. Therefore, it necessary research molecular basis of DOX‐induced organ and tissue damage protective agents. In this study, we aimed examine tannic acid (TA) against hepatoxicity experimental rat models. Rats were randomly divided into four groups: untreated control, DOX, TA, cotreatment (DOX + TA) groups. We investigated antioxidant system's main components oxidative stress indicators. Moreover, examined alterations mRNA expression critical regulators that modulate apoptosis, inflammation, cell metabolism better understand underlying factors liver toxicity. The results showed DOX exposure caused an increase MDA levels a significant depletion GSH content tissues. Consistent with stress‐related metabolites, was found significantly suppress both enzyme activities system components. had regulating other regulatory genes studied. However, determined TA could alleviate many negative changes by DOX. present study indicated might be considered versatile candidate prevent hepatotoxicity, possibly preserving physiology, viability, redox balance.

Language: Английский

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Antitumor Research Based on Drug Delivery Carriers: Reversing the Polarization of Tumor-Associated Macrophages

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The development of malignant tumors is a complex process that involves the tumor microenvironment (TME). An immunosuppressive TME presents significant challenges to current cancer therapies, serving as key mechanism through which cells evade immune detection and play crucial role in progression metastasis. This impedes optimal effectiveness immunotherapeutic approaches, including cytokines, checkpoint inhibitors, vaccines. Tumor-associated macrophages (TAMs), major component tumor-infiltrating cells, exhibit dual functionalities: M1-like TAMs suppress tumorigenesis, while M2-like promote growth Consequently, various nanocarriers aimed at polarizing phenotypes distinct mechanisms has emerged promising therapeutic strategy inhibit escape enhance antitumor responses. Review covers origin types TAMs, common pathways regulating macrophage polarization, progression, strategies targeting aiming provide comprehensive understanding guidance for future research clinical applications.

Language: Английский

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Potential Strategies for Overcoming Drug Resistance Pathways Using Propolis and Its Polyphenolic/Flavonoid Compounds in Combination with Chemotherapy and Radiotherapy

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3741 - 3741

Published: Oct. 31, 2024

Conventional cancer treatments include surgical resection, chemotherapy, hyperthermia, immunotherapy, hormone therapy, and locally targeted therapies such as radiation therapy. Standard often require the use of multiple agents, which can activate nuclear factor kappa B (NF-κB) in tumor cells, leading to reduced cell death increased drug resistance. Moreover, agents also contributes added toxicity, resulting poor treatment outcomes. Cancer cells gradually develop resistance almost all chemotherapeutics through various mechanisms, efflux, alterations metabolism transport, changes signal transduction pathways, enhanced DNA repair capacity, evasion apoptosis, mutations, reactivation targets, interaction with microenvironment, cell-stroma interactions, epithelial–mesenchymal transition (EMT)-mediated chemoresistance, epigenetic modifications, metabolic alterations, effect stem (CSCs). Developing new strategies improve chemotherapy sensitivity while minimizing side effects is essential for achieving better therapeutic outcomes enhancing patients’ quality life. One promising approach involves combining conventional propolis its flavonoids. These natural compounds may enhance response reducing toxicity. Propolis components sensitize chemotherapeutic likely by inhibiting NF-κB activation, reprogramming tumor-associated macrophages (TAMs; an M2-like phenotype), thereby release matrix metalloproteinase (MMP)-9, cytokines, chemokines, vascular endothelial growth (VEGF). By TAMs, overcome EMT-mediated disrupt crosstalk between CSCs, inhibit maintenance stemness, reverse acquired immunosuppression, thus promoting antitumor mediated cytotoxic T-cells. This review highlights potential flavonoids modulate responsiveness modalities. The evidence suggests that novel incorporating could be developed positive cytotoxicity peripheral blood leukocytes, liver, kidney cells. Therefore, polyphenolic/flavonoid hold combination clinical types cancers.

Language: Английский

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Ferroptosis-related signaling pathways in cancer drug resistance

Cancer Drug Resistance, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 6, 2025

Ferroptosis is an iron-dependent form of programmed cell death induced by lipid peroxidation. This process regulated signaling pathways associated with redox balance, iron metabolism, and metabolism. Cancer cells' increased demand makes them especially susceptible to ferroptosis, significantly influencing cancer development, therapeutic response, metastasis. Recent findings indicate that cells can evade ferroptosis downregulating key related this process, contributing drug resistance. underscores the possibility modulating as approach counteract resistance enhance efficacy. review outlines involved in their interactions cancer-related pathways. We also highlight current understanding resistance, offering insights into how targeting provide novel approaches for drug-resistant cancers. Finally, we explore potential ferroptosis-inducing compounds examine challenges opportunities development evolving field.

Language: Английский

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Network pharmacological analysis of Salidroside in the treatment of rectal cancer

New discovery., Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Feb. 10, 2025

Objective: This study aims to conduct a comprehensive bioinformatic analysis identify pharmacological targets in rectum tissue, rectal cancer and the effects of Salidroside. Methods: Genes associated with cancer, Salidroside were identified using MeSH retrieval from NCBI database screened GeneCards, TCMSP, HERB, ETCM databases. The overlapping genes visualized Venn diagram created on jvenn website. Protein-protein interactions (PPI), Gene Ontology (GO) analysis, Kyoto Encyclopedia Genomes (KEGG) pathway enrichment analyses performed STRING Metascape Results: Bioinformatic several key differentially expressed following treatment. A total 22 intersecting through PPI network revealed top 10 core proteins CytoHubba plugin. GO KEGG highlighted localization degree within signaling pathways. Conclusions: elucidated mechanisms underlying therapeutic providing theoretical foundation for future research.

Language: Английский

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ATM and p53 in aging and cancer: a double-edged sword in genomic integrity

Biogerontology, Journal Year: 2025, Volume and Issue: 26(3)

Published: May 5, 2025

Language: Английский

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Bibliometric analysis of research trends on the combination of radiotherapy and PARP inhibitors in solid tumors

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Introduction Radiotherapy has served as a cornerstone in cancer treatment for over century. However, the efficacy of radiotherapy is often compromised by intrinsic and acquired radioresistance tumors, which can lead to failure disease recurrence. Recent advancements preclinical clinical research have highlighted potential synergistic combining with poly-ADP-ribose polymerase inhibitors (PARPi), offering promising therapeutic avenues solid tumors. This study employs bibliometric analysis systematically evaluate evolution, trends, intellectual landscape on combination PARPi Methods Publications addressing tumors between 2005 2024 were retrieved from Web Science Core Collection (WOSCC) database. Bibliometric assessments conducted using VOSviewer CiteSpace analyze publication collaborative networks, foci. Results A total 901 articles included. The United States dominated output, University Texas MD Anderson Cancer Center identified most productive institution. Hannah Farmer emerged frequently cited author. Keywords co-occurrence revealed thematic shift foundational studies molecular mechanisms, such DNA damage response mechanism action PARPi, toward investigations evaluating therapy safety trials. Conclusion underscores rapid growth therapy, maintaining leading role due its extensive scientific infrastructure networks. field transitioned mechanistic explorations translational applications, reflecting progress optimization. These findings provide comprehensive overview knowledge structure within this domain serve strategic reference guiding future priorities implementations.

Language: Английский

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A comprehensive overview of radiation therapy impacts of various cancer treatments and pivotal role in the immune system

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(6)

Published: July 29, 2024

Abstract The cancer treatment landscape is significantly evolving, focusing on advanced radiation therapy methods to maximize effectiveness and minimize the adverse effects. Recognized as a pivotal component in disease treatment, (RT) has drawn attention recent research that delves into its intricate interplay with inflammation immune response. This exploration unveils underlying processes influence outcomes. In this context, potential advantages of combining bronchoscopy RT across diverse clinical scenarios, alongside targeted impact brachytherapy, are explored. Concurrently, treatments serve multifaceted roles such DNA repair, cell elimination, generating stress signaling molecules known damage‐associated molecular patterns, elucidating their treating various diseases. External beam introduces versatility by utilizing particles photons, electrons, protons, or carbon ions, each offering distinct advantages. Advanced techniques contribute evolving landscape, emerging technologies like FLASH, spatially fractionated RT, others poised revolutionize field. comprehension striving for improved outcomes, reduced side effects, facilitating personalized innovative noncancer patients. After navigating these advancements, goal fixed usher new era which cornerstone precision medical interventions. summarizing myriad findings, review underscores significance understanding differential impacts approaches modulation, valuable insights developing therapeutic interventions harness system conjunction RT.

Language: Английский

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