Insights into tumor-derived exosome inhibition in cancer therapy

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 285, P. 117278 - 117278

Published: Jan. 13, 2025

Language: Английский

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Extracellular vesicles and microRNAs in cancer progression

Advances in clinical chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Unraveling the role of the P2X7 receptor in cancer radioresistance: Molecular insights and therapeutic implications

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: 1872(3), P. 119910 - 119910

Published: Jan. 29, 2025

Language: Английский

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Nanobody-enhanced chimeric antigen receptor T-cell therapy: overcoming barriers in solid tumors with VHH and VNAR-based constructs

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 11, 2025

Abstract CAR-T cells are genetically modified T lymphocytes that express chimeric antigen receptors (CAR) on their surfaces. These enable to recognize specific antigens target cells, triggering a response leads targeted cytotoxicity. While therapy has effectively treated various blood cancers, it faces significant challenges in addressing solid tumors. include identifying precise tumor antigens, overcoming evasion, and enhancing the function of within microenvironment. Single domain antibody, versatile tools with low immunogenicity, high stability, strong affinity, show promise for improving efficacy against By these challenges, single antibody potential overcome limitations associated ScFv antibody-based therapies. This review highlights benefits utilizing therapy, particularly targeting explores development strategies could advance field.

Language: Английский

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Tumor-derived vesicles in immune modulation: focus on signaling pathways

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 15, 2025

Tumor-derived extracellular vesicles (TDEVs) represent a heterogeneous population of (EVs), including exosomes, microvesicles, and apoptotic bodies, which are essential for tumor growth. EVs function as natural carriers bioactive molecules, lipids, proteins, nucleic acids, enabling them to influence regulate complex cellular interactions within the microenvironment (TME). The TDEVs mainly have immunosuppressive functions result inhibitory signals disrupting immune cell anti-tumor activity. They enhance progression evasion by inhibiting effector cells altering critical processes recruitment, polarization, functional suppression different signaling pathways. In this sense, modulate NF-κB pathway, promoting inflammation inducing evasion. Janus kinase (JAK)-signal transducer activator transcription (STAT) is required TDEV-mediated manifestation tumor-supporting features. phosphoinositide 3-kinase (PI3K)/protein B (Akt)/mammalian target rapamycin (mTOR) signaling, necessary metabolic reprogramming, orchestrated TDEV abrogate response drive cancer proliferation. Finally, exosomal cargo can NOD-, LRR-, pyrin domain-containing protein 3 (NLRP3) inflammasome, activating pro-inflammatory responses that development immunomodulation. review, we take deep dive into how affect key We also examine emerging therapeutic approaches aimed at EV-mediated pathways, offering promising avenues novel EV-based immunotherapy.

Language: Английский

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Therapeutic vaccine strategies in cancer: advances, challenges, and future directions

Clinical Cancer Bulletin, Journal Year: 2025, Volume and Issue: 4(1)

Published: May 26, 2025

Language: Английский

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In Vitro Assessment of Antiproliferative Properties of a Novel Benzoxazole-Conjugated Pyrrolotriazinone

International Journal of Chemistry and Technology, Journal Year: 2025, Volume and Issue: 9(1), P. 107 - 116

Published: June 4, 2025

In this study, a new class of antiproliferative agents was designed and synthesized against glioblastoma, the most lethal aggressive primary brain tumor. The structure by hybridizing benzoxazole pyrrolotriazinone, two important pharmacophore groups for antiproliferation. target compound in six-step procedure. benzoxazole-conjugated pyrrolotriazinone characterized FT-IR, 1H- 13C-NMR spectra. It found to have favorable drug similarity theoretical pharmacokinetic parameters according silico methods. effect on glioblastoma cell line U-87 MG evaluated, showing dose-dependent effectiveness. Furthermore, study investigates molecular docking novel with key glioblastoma-associated targets, revealing its potential as multi-target therapeutic agent. demonstrates strong binding affinity inhibitory VEGFR-2, VEGFR-1, PI3K, shows significant activity apoptotic pathways through Caspase-3 BCL-2. These results suggest disrupt tumor growth, angiogenesis, proliferation. Overall, hybrid promise treatment could represent step forward design candidates future.

Language: Английский

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Fascial Manual Medicine: A Continuous Evolution

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

From the perspective of fascial manual medicine (FMM), body should not be considered as a set compartments, but functional continuum, where most tissues (considering embryology) are fascia. The cells that make up fascia can use multiple strategies to communicate, with neighboring cells, tissue which they belong, and entire body, thanks biochemical (microscopy) electromagnetic (nanoscopy) possibilities. These capacities send receive information border or layer different seem absent. All techniques profess only ones work on patient's symptoms, dictating standardized procedure all patients undergo, represent clinical deviation. Likewise, thinking approach provide biomechanical stimuli single specific structure is conceptual error. This narrative review briefly reviews history fascial-related nomenclature how system currently considered, posing new reflections continuum could conceived by practitioners who apply FMM in clinic, such osteopaths, chiropractors, physiotherapists.

Language: Английский

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Coagulation factor II thrombin receptor as a promising biomarker in breast cancer management

Open Life Sciences, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 1, 2024

Abstract This study aims to comprehensively investigate the role of coagulation factor II thrombin receptor (F2R) in breast cancer (BC) and evaluate its potential as a biomarker this context. Data on female BC were retrieved from TCGA database. Comparative analyses performed, including enrichment analysis, tumor immune microenvironment drug sensitivity testing, molecular docking, cell-based experiments, assess expression function F2R BC. Statistical graphical representations conducted using R software. The confirmed significant upregulation BC, which was associated with more favorable prognosis. Clinical correlation analysis revealed strong association between key clinical parameters, such estrogen progesterone status. Additionally, genes co-expressed significantly linked various biological processes, cell cycle regulation, oxidative phosphorylation, ribosomal function, extracellular matrix interactions. also showed associations modulators, particularly CD200 NRP1. Drug experiments consistently demonstrated positive correlations dasatinib. underscores valuable providing insights into mechanisms underlying tumorigenesis.

Language: Английский

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Extracellular vesicles of ADSCs inhibit ischemic stroke-induced pyroptosis through Gbp3 regulation: A role for the NLRP3/GSDMD signaling pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 146, P. 113881 - 113881

Published: Dec. 24, 2024

Language: Английский

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