Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease DOI Creative Commons
Ivo Carrasco‐Wong, J. Sánchez, Jaime Gutiérrez

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE excessive release damage-associated molecular patterns (DAMPs) into the maternal circulation. This DAMP-rich milieu acts on innate immune cells, inducing proinflammatory state elevated cytokines such as IL-1β and IL-18. in mother placenta results endothelial dysfunction strongly associated cardiovascular disorders. While immediate fetal risks are well-documented, accumulating evidence indicates that also confers long-term to mother, including hypertension, coronary heart disease, stroke, failure. The underlying mechanisms connecting these chronic conditions remain unclear. article explores potential role trained immunity (TRIM) mechanistic link between increased risk. We propose persistent exposure DAMPs during may epigenetically reprogram cells their progenitors, leading TRIM. reprogramming enhances inflammatory response subsequent stimuli, potentially contributing inflammation predispose women diseases later life. Understanding TRIM could provide novel insights pathophysiology PE-related complications identify targets for therapeutic intervention. Further research warranted investigate epigenetic metabolic alterations induced determine how changes influence health.

Language: Английский

Administration of Apis cerana cerana melittin gene-encapsulated pectin for breast cancer therapy: an investigation of a new anti-cancer agent DOI Creative Commons

Esmaeil Alibeigi,

Arsham Azari Dehkordi,

Milad Asadian

et al.

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 5, 2025

Language: Английский

Citations

0
Cyclophilin A and C are the Main Components of Extracellular Vesicles in Response to Hyperglycemia in BV2 Microglial Cells DOI Creative Commons

Noelia Castedo,

Amparo Alfonso, Rebeca Alvariño

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Cyclophilins (Cyps) and CD147 receptor play a crucial role in the inflammatory responses. Chronic inflammation causes tissue damage is common condition of several inflammation-based pathologies as diabetes or Alzheimer´s disease. Under high glucose (HG) conditions, microglia activated releases mediators. In this process Cyps unknown, so study was aimed to investigate profile their release through extracellular vesicles (EVs) under hyperglycemia. An increase reactive oxygen species (ROS) nitric oxide (NO) levels observed when BV2 glia cells were incubated with HG concentration. These effects mitigated by inhibitor cyclosporine A (CsA), suggesting implication activation. these conditions intracellular expression CypA, B, C D, well membrane increased. addition, only CypA CypC detected medium. Then, presence inside EVs explored an alternative secretion route. Interestingly, treatment, four observed. When neurons treated derived from HG-treated cells, viability reduced cytosol pointing EVs-Cyps neurotoxic effect. findings provide novel insights into relationship between neuroinflammation hyperglycemia conditions. The current results strengthen cell communication its potential brain function pathological

Language: Английский

Citations

0
Promoting activities of human cyclophilin A on calcium oxalate stone formation at crystal growth, aggregation and crystal-cell adhesion phases DOI Creative Commons

Sudarat Hadpech,

Waralee Srinarawat,

Visith Thongboonkerd

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143374 - 143374

Published: April 1, 2025

Kidney stone is a specialized form of biomineralization involving complex interactions between crystals and urinary macromolecules. Renal tubular cells secrete cyclophilin A (CyPA), protein whose elevated level associated with various kidney diseases. Nevertheless, its role in formation has not previously been explored. This study thus aimed to investigate roles CyPA through calcium oxalate (CaOx) crystal assays. Recombinant human was generated mimic secretory excreted into the urine. Crystal assays yielded first evidence demonstrating that significantly promoted CaOx growth, aggregation crystal-cell adhesion, all which are critical steps during initial formation. Despite lack specific Ca2+-binding Ox2--binding domains inability bind free Ca2+/Ox2- ions solution, demonstrated distinct ability crystals. Upon binding, facilitated further adjacent adhesion. These findings unravel novel mechanism pathogenesis, expanding known functions CyPA. research also provides solid how became one compositions matrix highlights potential be therapeutic/preventive target for management/prevention disease.

Language: Английский

Citations

0
Trained innate immunity as a potential link between preeclampsia and future cardiovascular disease DOI Creative Commons
Ivo Carrasco‐Wong, J. Sánchez, Jaime Gutiérrez

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

Preeclampsia (PE) is a complex pregnancy syndrome characterized by hypertension with or without proteinuria, affecting 2–6% of pregnancies globally. PE excessive release damage-associated molecular patterns (DAMPs) into the maternal circulation. This DAMP-rich milieu acts on innate immune cells, inducing proinflammatory state elevated cytokines such as IL-1β and IL-18. in mother placenta results endothelial dysfunction strongly associated cardiovascular disorders. While immediate fetal risks are well-documented, accumulating evidence indicates that also confers long-term to mother, including hypertension, coronary heart disease, stroke, failure. The underlying mechanisms connecting these chronic conditions remain unclear. article explores potential role trained immunity (TRIM) mechanistic link between increased risk. We propose persistent exposure DAMPs during may epigenetically reprogram cells their progenitors, leading TRIM. reprogramming enhances inflammatory response subsequent stimuli, potentially contributing inflammation predispose women diseases later life. Understanding TRIM could provide novel insights pathophysiology PE-related complications identify targets for therapeutic intervention. Further research warranted investigate epigenetic metabolic alterations induced determine how changes influence health.

Language: Английский

Citations

0