Correlation between the RNA Expression and the DNA Methylation of Estrogen Receptor Genes in Normal and Malignant Human Tissues

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(4), P. 3610 - 3625

Published: April 19, 2024

Estrogen plays a multifaceted function in humans via interacting with the estrogen receptors ERα, ERβ, and G protein-coupled receptor 1 (GPER1). Previous research has predominantly concentrated on elucidating signaling route of estrogen. However, comprehensive understanding expression profile control these various human tissues is not well known. In present study, RNA levels normal malignant were retrieved from protein atlas, cancer genome atlas (TCGA), genotype-tissue (GTEx) databases for analyzing through gene profiling interactive analysis (GEPIA). The status DNA methylation genes TCGA analyzed software Wanderer cBioPortal. MethSurv tool was utilized to estimate relevance between specific cytosine-guanine (CG) tumor survival. revealed that GPER1 have unique patterns diverse malignancies. interesting results higher ERβ male testis than females positive association level ERα androgen different tissues. Especially, significant changes multiple malignancies showed consistent decrease no exception, which indicates role common inhibition. finding provides clues exploring novel potential physiological pathophysiological functions manifested substantial correlation CG sites cis-regulating region gene. such observed ERβ. When comparing tissues, certain survival but did always correlate or methyltransferases. We proposed variation at had other beyond its regulatory expression, this might be associated progression therapy efficiency based modulation chromatin configuration.

Language: Английский

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization.

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111566 - 111566

Published: Dec. 11, 2024

Language: Английский