Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer Therapy
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(4), P. 535 - 535
Published: April 5, 2025
Pharmacogenomics
is
revolutionizing
precision
medicine
by
enabling
tailored
therapeutic
strategies
based
on
an
individual
genetic
and
molecular
profile.
Circular
RNAs
(circRNAs),
a
distinct
subclass
of
endogenous
non-coding
RNAs,
have
recently
emerged
as
key
regulators
drug
resistance,
tumor
progression,
responses.
Their
covalently
closed
circular
structure
provides
exceptional
stability
resistance
to
exonuclease
degradation,
positioning
them
reliable
biomarkers
novel
targets
in
cancer
management.
This
review
comprehensive
analysis
the
interplay
between
circRNAs
pharmacogenomics,
focusing
their
role
modulating
metabolism,
efficacy,
toxicity
profiles.
We
examine
how
circRNA-mediated
regulatory
networks
influence
chemotherapy
alter
targeted
therapy
responses,
impact
immunotherapy
outcomes.
Additionally,
we
discuss
emerging
experimental
tools
bioinformatics
techniques
for
studying
circRNAs,
including
multi-omics
integration,
machine
learning-driven
biomarker
discovery,
high-throughput
sequencing
technologies.
Beyond
diagnostic
potential,
are
being
actively
explored
agents
delivery
vehicles.
Recent
advancements
circRNA-based
vaccines,
engineered
CAR-T
cells,
synthetic
circRNA
therapeutics
highlight
transformative
potential
oncology.
Furthermore,
address
challenges
standardization,
reproducibility,
clinical
translation,
emphasizing
need
rigorous
validation
frameworks
facilitate
integration
into
practice.
By
incorporating
profiling
pharmacogenomic
strategies,
this
underscores
paradigm
shift
toward
highly
personalized
therapies.
hold
immense
overcome
enhance
treatment
optimize
patient
outcomes,
marking
significant
advancement
Language: Английский
Products of abortive transcription can prime synthesis of chimeric oligonucleotides
K.S. Shavkunov,
No information about this author
Natalia Markelova,
No information about this author
Оlga Alikina
No information about this author
et al.
Mathematical Biology and Bioinformatics,
Journal Year:
2024,
Volume and Issue:
19(2), P. 453 - 471
Published: Dec. 8, 2024
The
aim
of
the
study
was
to
search
for
signal
RNAs
potentially
utilized
by
bacteria
intercellular
interactions.
This
not
limited
a
certain
category
regulatory
RNAs,
which
are
contained
in
large
numbers
all
domains
life.
performed
using
RNA-seq
data
obtained
wild-type
strain
E.
coli
and
its
mutant
derivative
(Δdps)
lacking
gene
encoding
nucleoid
protein
Dps.
can
bind
is
found
membrane
structures,
indicates
possibility
participation
their
secretion.
Since
spectra
intracellular
secreted
differed,
it
assumed
that
somehow
selected
Therefore,
RNA
sets
with
Dps-dependent
secretion,
we
searched
reads
non-template
nucleotides
at
ends,
point
nucleotide
substitutions,
insertions
deletions,
as
well
regularly
detected
chimeras.
One
chimera
9-mer
GCCAAGGCG
5'-end
transcript
from
fimA-fimI
intergenic
region
3'-end
chosen
detailed
study.
It
product
abortive
transcription
antisense
promoter
inside
ravA
gene.
efficiently
forms
chimeras
many
including
5'-ends
fragments
shortened
this
terminus.
Analysis
partners
different
revealed
coding
sites
genome,
feature
ability
form
stable
secondary
structures
therefore
cause
stops
or
pauses.
discovery
witnesses
they
formed
result
primed
synthesis
rather
than
random
ligation.
possible
biological
role
products,
whose
has
been
established
first
time,
discussed.
Language: Английский