Risk factors for severe COVID-19 infection and the impact of COVID-19 infection on disease progression among patients with AAV DOI Creative Commons
Chen Wang, Zhiying Li, Guiping Jiang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 9, 2024

Abstract Objective To identify risk factors for COVID-19 infection and investigate the impact of on chronic kidney disease (CKD) progression vasculitis flare in patients with antineutrophil cytoplasmic antibody (ANCA)-associated (AAV). Methods This cohort study retrospectively analyzed prevalence severity 276 AAV who were followed up. Logistic regression was employed to estimate as well CKD upon infection. Results During 6-month observation period, 213 (77.2%) had a diagnosis Of these patients, 49 (23.0%) COVID-19-related inpatient admission, including 17 died severe more likely be male (OR 1.921 [95% CI 1.020–3.619], P = 0.043), suffered from worse function (serum creatinine [Scr], OR 1.901 1.345–2.687], < 0.001), higher C-reactive protein (CRP) 1.054 1.010–1.101], 0.017) less have evidence initial vaccination 0.469 0.231–0.951], 0.036), Scr proven significantly associated even after multivariable adjustment. Severe subsequent 7.929 2.030-30.961], 0.003) 11.842 1.048-133.835], 0.046) among AAV. Conclusion male, susceptible infection, which subsequently increased flare.

Language: Английский

Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

29
Interleukin-33 modulates NET formation via an autophagy-dependent manner to promote neutrophilic inflammation in cigarette smoke-exposure asthma DOI
Jing Liu,

Peizhi Tao,

Beiting Su

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137257 - 137257

Published: Jan. 16, 2025

Language: Английский

Citations

1
Neutrophil extracellular traps in tumor metabolism and microenvironment DOI Creative Commons

Z. Liu,

Yuanyao Dou, Conghua Lu

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.

Language: Английский

Citations

1
Genetically Engineered Cellular Nanovesicle as Targeted DNase I Delivery System for the Clearance of Neutrophil Extracellular Traps in Acute Lung Injury DOI Creative Commons
Yang Du, Yining Chen, Fangyuan Li

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(32)

Published: Sept. 27, 2023

Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are prevalent critical illnesses with a high mortality rate among patients in intensive care units. Neutrophil extracellular traps (NETs) implicated the pathogenesis of ALI/ARDS and represent promising therapeutic target. However, clinical application deoxyribonuclease I (DNase I), only drug currently available to clear NETs, is limited due lack precise efficient delivery strategies. Therefore, targeted DNase inflamed remains issue be addressed. Herein, novel biomimetic system developed (DCNV) that employs genetically bioorthogonally engineered cellular nanovesicles for pulmonary NETs clearance. The CXC motif chemokine receptor 2 overexpressed can mimic inflammatory chemotaxis neutrophils ALI/ARDS, leading enhanced accumulation. Furthermore, immobilized through bioorthogonal chemistry exhibits remarkable enzymatic activity degradation, thus restraining inflammation safeguarding tissue lipopolysaccharide‐induced ALI murine model. Collectively, findings present groundbreaking proof‐of‐concept utilization deliver treating ALI/ARDS. This innovative strategy may usher new era development pharmacological interventions various inflammation‐related diseases.

Language: Английский

Citations

21
Induction of protective immune responses at respiratory mucosal sites DOI Creative Commons
Seok‐Chan Park,

Matthew J. Wiest,

Vivian Yan

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: July 2, 2024

Many pathogens enter the host through mucosal sites. Thus, interfering with pathogen entry local neutralization at sites therefore is an effective strategy for preventing disease. Mucosally administered vaccines have potential to induce protective immune responses This manuscript delves into some of latest developments in vaccination, particularly focusing on advancements adjuvant technologies and role these adjuvants enhancing vaccine efficacy against respiratory pathogens. It highlights anatomical immunological complexities system, emphasizing significance secretory IgA tissue-resident memory T cells responses. We further discuss differences between induced traditional parenteral vaccination approaches vs. administration strategies, explore advantages offered by immunization routes.

Language: Английский

Citations

7
Deep insight into cytokine storm: from pathogenesis to treatment DOI Creative Commons
Jiali Nie, Ling Zhou,

Weiwei Tian

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: April 15, 2025

Abstract Cytokine storm (CS) is a severe systemic inflammatory syndrome characterized by the excessive activation of immune cells and significant increase in circulating levels cytokines. This pathological process implicated development life-threatening conditions such as fulminant myocarditis (FM), acute respiratory distress (ARDS), primary or secondary hemophagocytic lymphohistiocytosis (HLH), cytokine release (CRS) associated with chimeric antigen receptor-modified T (CAR-T) therapy, grade III to IV graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. The involvement JAK-STAT pathway, Toll-like receptors, neutrophil extracellular traps, NLRP3 inflammasome, other signaling pathways has been recognized pathogenesis CS. Therapies targeting these have developed are currently being investigated. While novel drugs demonstrated promising therapeutic efficacy mitigating CS, overall mortality rate CS resulting from underlying diseases remains high. In clinical setting, management typically necessitates multidisciplinary team strategy encompassing removal abnormal system activation, preservation vital organ function, treatment disease, provision life supportive therapy. review provides comprehensive overview key cytokines elucidates impact dysregulated delineates resultant injury addition, we offer insights current literature on cases FM, ARDS, response syndrome, treatment-induced CRS, HLH, related conditions.

Language: Английский

Citations

0
Urine Neutrophil Elastase: A Novel Predictor of ICU Admission for Patients with COVID-19 Infection DOI Creative Commons
Yu Song, Kai Zeng, Likun Zhang

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 5545 - 5553

Published: April 1, 2025

We aimed to explore the differences of neutrophil elastase (NE) levels between intensive care unit (ICU) and non-ICU patients with COVID-19 infection, as well its predictive value for progression. enrolled admitted a primary diagnosis COVID-19. All in ICU were diagnosed critical type upon admission. Blood was taken within 24 hours, followed by examination blood NE level urine level. Other clinical features recorded. A logistic regression model used predict total 83 diagnosed, including 52 cases 31 cases. The group showed significantly elevated Neutrophil%, Cr, D-dimer (DD), Procalcitonin (PCT), C-reactive protein (CRP). Meanwhile, CD3-cell, T4-cell, Lymphocyte% lower group. Notably, similar groups, whereas highly higher vs After dimension reduction, we constructed (UD) using only two factors: DD overall accuracy 86.1%. has strong efficacy prediction (AUC = 0.893), performance UD even better 0.933). Urine is useful predictor progression, particularly requiring care. positive correlation neutrophil%, DD, PCT, negative lymphocyte levels.

Language: Английский

Citations

0
Increased serum levels of IL-40 are associated with IgA and NETosis biomarkers in Covid-19 patients: IL-40 and infectious diseases DOI Creative Commons
Emin Ümit Bağrıaçık, Resul Karakuş, Melek Yaman

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(5), P. e0321578 - e0321578

Published: May 2, 2025

Interleukin 40 (IL-40) is a novel cytokine that has been associated with B lymphocytes, particularly IgA-secreting cells in gut mucosa. Considering mucosal association of IL-40, we aimed to determine serum IL-40 levels patients Covid-19. We compared concentrations healthy people both mild symptoms SARS-CoV-2 infection and pneumonia. was measured by ELISA. Serum IgA were tested nephelometry. For the first time, demonstrated increased significantly. The elevation related severity infection. Therefore, quite higher Our findings indicated NETosis biomarkers increase. Based on these findings, speculated would be immune activities mucosa lungs SARS-CoV-2-infected patients. This may linked mechanism control NETosis.

Language: Английский

Citations

0
Targeting NETosis: nature’s alarm system in cancer progression DOI Open Access

Yixia Liang,

Guo Wu,

Jiabao Tan

et al.

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: July 19, 2024

Neutrophils are recognized active participants in inflammatory responses and intricately linked to cancer progression. In response stimuli, neutrophils become activated, releasing extracellular traps (NETs) for the capture eradication of pathogens, a phenomenon termed NETosis. With deeper understanding NETs, there is growing evidence supporting their role progression involvement conferring resistance various therapies, especially concerning tumor reactions chemotherapy, radiation therapy (RT), immunotherapy. This review summarizes roles NETs microenvironment (TME) mechanisms neutrophil host defense. Additionally, it elucidates through which promote treatment resistance, highlighting potential as promising therapeutic targets clinical applicability.

Language: Английский

Citations

3
SARS-CoV-2 disrupts host gene networks: Unveiling key hub genes as potential therapeutic targets for COVID-19 management DOI Creative Commons
Marta Majewska, Mateusz Maździarz, Katarzyna Krawczyk

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 183, P. 109343 - 109343

Published: Nov. 4, 2024

Language: Английский

Citations

3