Kojic acid alleviates osteoarthritis by attenuating inflammation and restoring impaired autophagy through regulating NF-κB and PI3K/AKT/mTOR signaling pathways: An in vivo and in vitro study DOI Creative Commons
Junhong Li, Guihua Yu,

Zhiyong He

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114022 - 114022

Published: Jan. 6, 2025

Osteoarthritis (OA) is the most prevalent joint disorder globally, causing a substantial and increasing socioeconomic burden. Kojic acid (KA) presented potential biological roles in regulating inflammation autophagy, which was implicated OA progression. However, its role chondrocytes has not been reported. To do so, this study aims to explore chondroprotective effect of KA elucidate regulatory mechanisms. IL-1β vitro used induce OA-like phenotypes. Cell viability measured by cell counting kit-8 assay. RT-qPCR, western blotting, as well immunofluorescence staining were assess protein RNA expression inflammatory (COX2 iNOS), catabolic (MMP13 MMP3), anabolic (collagen II, aggrecan SOX9), signaling pathways factors. Destabilized medial meniscus (DMM) surgery adopted build model vivo. After consecutive 8 weeks intra-articular injection KA, X-ray, μ-CT, histological staining, immunohistochemistry evaluate effects on articular cartilage did affect chondrocyte viability. notably elevated factors expression, simultaneously, inhibited vitro. Mechanistically, significantly suppressed activated NF-κB PI3K/AKT/mTOR pathways. Moreover, impaired autophagy restored KA. Inhibition 3-MA diminished Intra-articular can alleviate DMM-induced damage Collectively, our work first demonstrate that osteoarthritis attenuatinginflammationand restoring through relevant This vivo provides strong evidence supportingKA novel valuable approach for treating OA.

Language: Английский

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review DOI Creative Commons
Jana Riegger, Astrid Schoppa,

Leonie Ruths

et al.

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Sept. 30, 2023

Abstract During aging and after traumatic injuries, cartilage bone cells are exposed to various pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated molecular patterns, proinflammatory cytokines. This detrimental environment triggers cellular stress subsequent dysfunction, which not only contributes the development of associated diseases, that is, osteoporosis osteoarthritis, but also impairs regenerative processes. To counter ROS-mediated reduce overall tissue damage, possess diverse defense mechanisms. However, antioxidative capacities limited thus ROS accumulation can lead aberrant cell fate decisions, have adverse effects on homeostasis. In this narrative review, we address oxidative as a major driver processes in bone, senescence, misdirected differentiation, death, mitochondrial impaired mitophagy by illustrating consequences homeostasis regeneration. Moreover, elaborate mechanisms, with particular focus response mitophagy, briefly discuss respective therapeutic strategies improve protection.

Language: Английский

Citations

70
Insights and implications of sexual dimorphism in osteoporosis DOI Creative Commons
Yuanyuan Zhang, Na Xie,

Xiaodong Sun

et al.

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Feb. 18, 2024

Osteoporosis, a metabolic bone disease characterized by low mineral density and deterioration of microarchitecture, has led to high risk fatal osteoporotic fractures worldwide. Accumulating evidence revealed that sexual dimorphism is notable feature osteoporosis, with sex-specific differences in epidemiology pathogenesis. Specifically, females are more susceptible than males while prone disability or death from the disease. To date, sex chromosome abnormalities steroid hormones have been proven contribute greatly osteoporosis regulating functions cells. Understanding its related complications essential for improving treatment strategies tailored women men. This literature review focuses on mechanisms underlying mainly population aging patients, chronic glucocorticoid administration, diabetes. Moreover, we highlight implications developing therapeutics preventive screening approaches Additionally, challenges translating bench research bedside treatments future directions overcome these obstacles will be discussed.

Language: Английский

Citations

27
Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in osteoporotic mice DOI Creative Commons

Kun Yan,

Ruikun Zhang, Jiaxin Wang

et al.

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: Jan. 3, 2025

Yigu decoction (YGD) is a traditional Chinese medicine prescription for the treatment of osteoporosis, although many clinical studies have confirmed its anti-OP effect, but specific mechanism still not completely clear.

Language: Английский

Citations

2
Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration DOI Creative Commons

Xuwei Jiang,

Sun Yu-xiang,

Yuanning Lyu

et al.

BMEMat, Journal Year: 2024, Volume and Issue: 2(2)

Published: March 1, 2024

Abstract Osteoarthritis (OA) is a chronic and degenerative disease with limited clinical options for effective suppression. Recently, significant endeavors have been explored to reveal its pathogenesis develop treatments against OA. Hydrogels, designed striking resemblance the extracellular matrix, offer biomimetic interaction biological tissues, presenting promising avenue OA amelioration. As result, biocompatible hydrogels erected incorporating on‐demand bioactivities optimize intra‐articular microenvironment, thereby alleviating symptoms fostering eventual regeneration of articular joints. This review highlights collaborative objectives underlying establishment this tissue encompassing mechanical modulation, anti‐inflammation, regeneration. Specifically, we consolidate recent advances in hydrogel‐based biomaterials, serving as engineering scaffolds replicate lubrication properties natural joints or bioactive agent‐loaded vehicles combat localized inflammation. Additionally, function cell facilitate maintenance cellular homeostasis contribute advancement cartilage Finally, outlines prospective directions hydrogel‐mediated therapies.

Language: Английский

Citations

14
A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment DOI Creative Commons

Shi-Yuan Yang,

Yan Zhu,

Chunxiao Ji

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 239 - 256

Published: July 24, 2024

Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are currently primary challenges to control progression rebuild damaged bone. However, existing treatments for periodontitis fail comprehensively address these issues. Herein, an injectable composite hydrogel (SFD/CS/ZIF-8@QCT) encapsulating quercetin-modified zeolitic imidazolate framework-8 (ZIF-8@QCT) developed. This possesses thermo-sensitive adhesive properties, which can provide excellent flowability post-injection stability, resist oral fluid washout as well achieve effective tissue adhesion. Inspirationally, it observed SFD/CS/ZIF-8@QCT exhibits rapid localized hemostatic effect following implantation, then virtue sustained release zinc ions quercetin exerts collective functions including antibacterial, immunomodulation, pro-osteo-/angiogenesis pro-recruitment, ultimately facilitating regeneration. Notably, our study also demonstrates inhibition PDLSCs under due strong energy metabolism powerful activation oxidative stress autophagy, whereas synergistic effects released reversing biological processes. Overall, presents innovative insights into advancement biomaterials regenerate periodontitis.

Language: Английский

Citations

14
Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies DOI Creative Commons
Xiaocui Chen, Zhuowen Hao, Hanke Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 3859 - 3899

Published: Jan. 1, 2024

Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve medication hormone therapy. However, these lack directionality are often ineffective for locally severe osteoporosis, with the potential complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as most promising approaches. This review proposes twelve microenvironmental targets osteoporosis-related pathological changes, including local accumulation of inflammatory factors reactive oxygen species (ROS), mitochondrial dynamics, insulin resistance, disruption cell autophagy, apoptosis, changes in neural secretions, aging cells, increased tissue vascular destruction, decreased regeneration. Additionally, this examines current research status effective biophysical biochemical stimuli based on summarizes advantages optimal parameters different bioengineering to support preclinical clinical osteoporosis Finally, addresses ongoing challenges future prospects.

Language: Английский

Citations

12
Glycolysis: an emerging regulator of osteoarthritis DOI Creative Commons

Dingming Jiang,

Jianan Guo,

Yingquan Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 9, 2024

Osteoarthritis (OA) has been a leading cause of disability in the elderly and there remains lack effective therapeutic approaches as mechanisms pathogenesis progression have yet to be elucidated. As OA progresses, cellular metabolic profiles energy production are altered, emerging reprogramming highlights importance specific pathways disease progression. crucial part glucose metabolism, glycolysis bridges inflammatory dysfunctions. Moreover, glycolytic pathway is involved different areas metabolism inflammation, associated with variety transcription factors. To date, it not fully elucidated whether changes its key enzymes onset or OA. This review summarizes important role mediating inducing tissue inflammation injury, aim providing further insights into pathological functions proposing new targets for treatment

Language: Английский

Citations

11
Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues DOI Creative Commons
Wenlong Chen,

Qiufei Wang,

Huaqiang Tao

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

Osteoarthritis (OA) is the most common joint disease, and good therapeutic results are often difficult to obtain due its complex pathogenesis diverse causative factors. After decades of research exploration OA, it has been progressively found that subchondral bone essential for pathogenesis, pathological changes in can be observed even before cartilage lesions develop. Osteoclasts, main cells regulating resorption, play a crucial role bone. Subchondral osteoclasts regulate homeostasis through secretion degradative enzymes, immunomodulation, cell signaling pathways. In overactivated by autophagy, ncRNAs, Rankl/Rank/OPG Excessive resorption disrupts balance remodeling, leading increased loss, decreased mineral density consequent structural damage articular pain. With understanding biology targeted therapies, researchers have activity function affected multiple this review, we summarize roles mechanisms enumerate latest advances osteoclast-targeted therapy look forward future trends therapies clinical applications fill gaps current knowledge OA treatment develop new strategies.

Language: Английский

Citations

8
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis DOI

Qishun Geng,

Jiahe Xu,

Xiaoxue Cao

et al.

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 146, P. 103214 - 103214

Published: April 21, 2024

Language: Английский

Citations

8
SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets DOI Open Access
Luning Yang,

Di Liu,

Shide Jiang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 116917 - 116917

Published: June 21, 2024

Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass, strength, and physical function, severely affecting the quality of life (QoL) elderly population. Sirtuin 1 (SIRT1), as a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases, has been reported to participate in various signaling pathways exert protective effect on many human diseases. SIRT1 functioned important role occurrence progression sarcopenia through regulating key related protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance autophagy muscle, including SIRT1/Forkhead Box O (FoxO), AMP-activated kinase (AMPK)/SIRT1/nuclear factor κB (NF-κB), SIRT1/p53, AMPK/SIRT1/peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), SIRT1/live B1 (LKB1)/AMPK pathways. However, specific mechanisms these processes have not fully illuminated. Currently, several SIRT1-mediated interventions preliminarily developed, such activator polyphenolic compounds, exercising calorie restriction. In this review, we summarized predominant involved therapeutic modalities targeting for prevention prognosis sarcopenia.

Language: Английский

Citations

8