VPS13 and bridge-like lipid transporters, mechanisms, and mysteries DOI Creative Commons
Laura E. Swan

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 28, 2025

Bridge-like lipid transporters (BLTPs) have recently been revealed as key regulators of intraorganellar trafficking, with their loss being associated defective synaptic signalling and congenital neurological diseases. This group consists five protein subfamilies [BLTP1-3, autophagy-related 2 (ATG2), vacuolar sorting 13 (VPS13)], which mediate minimally selective transfer between cellular membranes. Deceptively simple in both structure presumed function, this review addresses open questions to how bridge-like work, the functional consequences bulk on signalling, summarises some recent studies that shed light surprising level regulation specificity found family transporters.

Language: Английский

Neuronal autophagy in the control of synapse function DOI Creative Commons
Anna Karpova, P. Robin Hiesinger, Marijn Kuijpers

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Neurons are long-lived postmitotic cells that capitalize on autophagy to remove toxic or defective proteins and organelles maintain neurotransmission the integrity of their functional proteome. Mutations in genes cause congenital diseases, sharing prominent brain dysfunctions including epilepsy, intellectual disability, neurodegeneration. Ablation core neurons glia disrupts normal behavior, leading motor deficits, memory impairment, altered sociability, which associated with defects synapse maturation, plasticity, neurotransmitter release. In spite importance for physiology, substrates neuronal mechanisms by affect synaptic function health disease remain controversial. Here, we summarize current state knowledge autophagy, address existing controversies inconsistencies field, provide a roadmap future research role control function.

Language: Английский

Citations

0
TGFB signaling induces mitophagy via PLSCR3-mediated cardiolipin externalization in conjunction with a BNIP3L/NIX-, BNIP3-, and FUNDC1-dependent mechanism DOI
Jiong Yan, Xin Chen,

Swati Choksi

et al.

Autophagy, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Selective clearance of damaged mitochondria through mitophagy is crucial for the maintenance mitochondrial homeostasis. While can be activated by various toxins, physiologically relevant signal that triggers less studied. TGFB/TGFβ signaling has been linked to autophagic induction, but its specific role in not well understood. Here, we discovered a novel induction paradigm stimulated TGFB1. The mitophagic response exclusively mediated SMAD2, SMAD3, and SMAD4 underlying TGFB receptor signaling. transcriptional regulation activates genes involved canonical pathway which required TGFB1-induced mitophagy. Moreover, TGFB1 promotes flux upregulating PLSCR3 externalizes cardiolipin conjunction with MAP1LC3/LC3/GABARAPs-interacting proteins (BNIP3L/NIX, BNIP3, FUNDC1)-dependent mechanism. Overall, our study characterized essential components engaged demonstrated an important induces

Language: Английский

Citations

0
Molecular and epigenetic responses to crowding stress in rainbow trout (Oncorhynchus mykiss) skeletal muscle DOI Creative Commons
Daniela Aravena-Canales, Valentina Valenzuela-Muñóz, Cristian Gallardo‐Escárate

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Chronic stress is a critical challenge in fish aquaculture, adversely affecting growth, health, and overall productivity. Among the most significant chronic stressors intensive farming crowding, which triggers release of cortisol, primary hormone fish. Cortisol re-allocates energy away from growth-related processes toward response mechanisms. Consequently, overcrowded often exhibit slower growth rates, impaired skeletal muscle development. Understanding mechanisms underlying crowding their long-term effects, including epigenetic changes, essential for optimizing conditions, enhancing welfare. This study aims to characterize physiological, transcriptomic, epigenomic responses juvenile rainbow trout (Oncorhynchus mykiss) exposed 30 days high stocking densities. Crowding led decreased weight high-density (HD) group. It also resulted elevated cortisol levels, oxidative DNA damage, protein carbonylation muscle. Using RNA-seq, we identified 4,050 differentially expressed genes (DEGs), through whole-genome bisulfite sequencing (WGBS), detected 11,672 methylated (DMGs). Integrative analyses revealed 263 with negative correlation between upregulated expression downregulated methylation, primarily associated autophagy, mitophagy, insulin signaling pathway. Conversely, 299 exhibited reverse trend, mainly linked ATP-dependent chromatin remodeling. offers first detailed exploration molecular stress, integrating RNA-seq WGBS analysis trout, offering valuable information improving aquaculture practices.

Language: Английский

Citations

0
VPS13 and bridge-like lipid transporters, mechanisms, and mysteries DOI Creative Commons
Laura E. Swan

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 28, 2025

Bridge-like lipid transporters (BLTPs) have recently been revealed as key regulators of intraorganellar trafficking, with their loss being associated defective synaptic signalling and congenital neurological diseases. This group consists five protein subfamilies [BLTP1-3, autophagy-related 2 (ATG2), vacuolar sorting 13 (VPS13)], which mediate minimally selective transfer between cellular membranes. Deceptively simple in both structure presumed function, this review addresses open questions to how bridge-like work, the functional consequences bulk on signalling, summarises some recent studies that shed light surprising level regulation specificity found family transporters.

Language: Английский

Citations

0