In vitro activation of the CB₁ receptor by the semi‐synthetic cannabinoids hexahydrocannabinol (HHC), hexahydrocannabinol acetate (HHC‐O) and hexahydrocannabiphorol (HHC‐P)

Drug Testing and Analysis, Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

Abstract Semi‐synthetic cannabinoids (SSCs) including hexahydrocannabinol (HHC) are emerging on the drug market and sold openly as purportedly legal replacements for cannabis Δ 9 ‐THC. By beginning of 2024, 24 European countries had identified HHC, often in edibles (foods/candy), vapes low‐THC flowers resins. The SSC is developing rapidly, with HHC acetate (HHC‐O), hexahydrocannabiphorol (HHC‐P) others recently identified. These developments may mark first major change ‘legal’ to since ‘Spice’ containing synthetic cannabinoids, such JWH‐018, emerged 2008. Currently, there some data available pharmacology SSCs, which crucial understanding their effects, evaluating health risks informing public responses. This study focused characterizing vitro activation human CB 1 receptor by ( R ) ‐ S epimers HHC‐P HHC‐O. Using recombinant CHO‐K1 cells expressing receptor, potency (EC 50 efficacy were determined. It was established that (9 )‐HHC )‐HHC‐P activated partial agonists five two times lower compared respectively, while exhibited even potency. epimer HHC‐O activate lesser extent )‐epimer showed no activation. For HHC‐P, all similar level efficacy. evidence suggests cannabimimetic effects tested exception acetates likely function pro‐drugs vivo.

Language: Английский

---

The Association Between Past 12-Month Synthetic Cannabinoid Polysubstance Use and Cannabis Use Disorder in a Nationally Representative US Sample

International Journal of Mental Health and Addiction, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

---

Retail Availability of Delta-8 THC Near Schools, Fort Worth, Texas, 2021

Health Behavior Research, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 16, 2025

Delta-8 THC (D8) is an intoxicating compound linked to poisonings and hospitalizations, no federal laws prohibit its sale minors. We examined retail D8 availability near public schools (n=231) in Fort Worth, Texas, where sales are minimally regulated. Between September-October 2021, trained data collectors collected from 1,178 retailers with alcohol, tobacco, and/or consumable hemp licenses. differences product for (within 0.5 miles) vs. not schools. There was a higher prevalence of selling (vs. near) (12.4% 8.2%; chi-square test 5.84, p<0.05). Of the 231 schools, 37.2% (n=86) had at least one retailer nearby. 86 nearby, cheapest products were vaping (40.7%) edibles (31.4%). school-level racialized socioeconomic inequities availability. Ongoing surveillance urgently needed.

Language: Английский

---

Accidental Synthetic Cannabinoid Poisoning in a Pediatric Patient: A Case Report

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

A six-year-old boy presented to the pediatric emergency department following an accidental ingestion of a synthetic cannabinoid. The child ingested edible product containing tetrahydrocannabinol (THC) and with lethargy, altered mental status, increased muscle tone. airway was protected, patient breathing spontaneously. Initial assessment included thorough history provided by caregivers, which confirmed cannabinoid gummies approximately two hours prior presentation. An electrocardiogram demonstrated sinus tachycardia prolonged QTc. Toxicology screening presumed positive for cannabinoids. Therapeutic management focused on supportive care. admitted hospital discharged day no neurologic sequelae. caregivers were expectant counseled regarding safe storage use cannabis cannabis-derived products. This case report discusses growing incidence exposure in population while highlighting biochemistry, clinical presentation, therapeutic

Language: Английский

---

Severe Outcomes in Suspected Pediatric Delta-8-THC Exposures

Journal of Medical Toxicology, Journal Year: 2024, Volume and Issue: 21(1), P. 89 - 92

Published: Dec. 24, 2024

Language: Английский

---