Spatial Omics and Gene Circuits DOI

Shantagoud Biradar,

Chandana Korrapati,

R. Krishna

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 383 - 408

Published: Dec. 17, 2024

Spatial transcriptomics is a powerful tool in biomedical research that enables the analysis of gene expression patterns within their spatial context. By providing insights into organisation expression, this technology can help address limitations design synthetic circuits controlled manner. In cancer biology, combining with other approaches allows researchers to gain deeper understanding spatiotemporal dynamics regulation. This method has significant potential for revealing tissue architecture and cellular heterogeneity, which complements circuits. study explores advantages circuit analysis, focusing on integrating these techniques understand better temporal regulation genes tissues.

Language: Английский

Depressive symptoms partially mediate the relationship between psychosocial factors and epigenetic age acceleration in a multi-racial/ethnic sample of older adults DOI Creative Commons

Lauren Opsasnick,

Wei Zhao, Lauren Schmitz

et al.

Brain Behavior & Immunity - Health, Journal Year: 2025, Volume and Issue: 45, P. 100994 - 100994

Published: April 13, 2025

Psychosocial factors, including cumulative psychosocial stress and loneliness, have been linked to epigenetic aging in older adults. Further, depressive symptoms established relationships with both factors aging. However, it is not known whether mediate the association between aging.We conducted linear regression models examine associations stress, five age acceleration (AA) measures estimated by DNA methylation a multi-racial/ethnic sample of 2681 adults from Health Retirement Study (mean age: 70.4 years). For all identified associations, we tested for effect modification sex educational attainment performed mediation analysis characterize role on these associations.Psychosocial were each associated at least one measure AA (FDR q < 0.05). observed interactions DunedinPACE, as well loneliness GrimAA, PhenoAA, females individuals without college degree appearing more sensitive effects Depressive mediated 24 % 35 HannumAA, 40 37 GrimAA respectively. this study may help elucidate relationship aging, which critical understanding biological mechanisms through contribute age-related disease.

Language: Английский

Citations

0
Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study DOI Creative Commons
Eileen M. Crimmins, Eric T. Klopack, Jung Ki Kim

et al.

Epigenomics, Journal Year: 2024, Volume and Issue: 16(14), P. 1031 - 1042

Published: July 17, 2024

Aim: This is a brief description of links between nine epigenetic clocks related to human aging and socioeconomic behavioral characteristics as well health outcomes. Materials & methods: We estimate frequently used novel from one data source, the Health Retirement Study. Results: While all these are thought reflect "aging," they use different CpG sites do not strongly relate each other. First fourth generation linked status or outcomes second third clocks. Conclusion: Epigenetic exciting new tools their continued evolution likely improve our understanding how exposures get under skin accelerate aging.

Language: Английский

Citations

3
Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS) DOI Creative Commons

Lauren Opsasnick,

Wei Zhao, Scott M. Ratliff

et al.

Clinical Epigenetics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Dec. 18, 2024

Abstract Background Exposure to psychosocial stress is linked a variety of negative health outcomes, including cardiovascular disease and its cardiometabolic risk factors. DNA methylation has been associated with both disease; however, little known about the mediating role on association between risk. Thus, using high-dimensional mediation testing method, we conducted an epigenome-wide analysis relationship ten factors in multi-racial/ethnic population older adults ( n = 2668) from Health Retirement Study (mean age 70.4 years). Results A total 50, 46, 7, 12 CpG sites across epigenome mediated effects body mass index, waist circumference, high-density lipoprotein cholesterol, C-reactive protein, respectively. When reducing dimensionality mediators their top 10 uncorrelated principal components (PC), cumulative effect PCs explained 35.8 46.3% these associations. Conclusions subset were expression genes enriched pathways related cytokine binding receptor activity, as well neuron development. Findings this study help elucidate underlying mechanisms through which partially mediates

Language: Английский

Citations

2
Spatial Omics and Gene Circuits DOI

Shantagoud Biradar,

Chandana Korrapati,

R. Krishna

et al.

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 383 - 408

Published: Dec. 17, 2024

Spatial transcriptomics is a powerful tool in biomedical research that enables the analysis of gene expression patterns within their spatial context. By providing insights into organisation expression, this technology can help address limitations design synthetic circuits controlled manner. In cancer biology, combining with other approaches allows researchers to gain deeper understanding spatiotemporal dynamics regulation. This method has significant potential for revealing tissue architecture and cellular heterogeneity, which complements circuits. study explores advantages circuit analysis, focusing on integrating these techniques understand better temporal regulation genes tissues.

Language: Английский

Citations

0