Published: Jan. 1, 2024
Language: Английский
Journal of Molecular Graphics and Modelling, Journal Year: 2025, Volume and Issue: 137, P. 109009 - 109009
Published: March 10, 2025
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(8), P. 1788 - 1788
Published: April 16, 2025
Neglected tropical diseases (NTDs), including Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria, remain a major global health challenge, disproportionately affecting low-income populations. Current therapies for these suffer from significant limitations, such as reduced efficacy, high toxicity, emerging parasite resistance, highlighting the urgent need new therapeutic strategies. In response, substantial efforts have been directed toward synthesis of molecules with improved potency, selectivity, pharmacokinetic profiles. However, despite many compounds exhibiting favorable ADMET (absorption, distribution, metabolism, excretion, toxicity) profiles strong in vitro activity, their translation into vivo models remains limited. Key challenges include lack investment, absence fully representative experimental models, difficulties extrapolating cell-based assay results to more complex biological systems. this review, we analyzed latest advancements (2019–2024) development compound classes, correlating predictive parameters observed activity. Among parameters, highlighted partition coefficient (LogP), which measures compound’s lipophilicity influences its ability cross membranes, Caco-2 cell permeability, an model widely used predict intestinal drug absorption. Additionally, prioritized most promising structural classes pharmaceutical development, discussing structure–activity relationships (SARs) remaining that must be overcome enable clinical application treatment NTDs.
Language: Английский
Citations
0
RSC Advances, Journal Year: 2024, Volume and Issue: 14(50), P. 36989 - 37018
Published: Jan. 1, 2024
Due to the important role of protein kinases in phosphorylation within vital cellular processes, their abnormal function, especially cancer situations, has underscored importance therapy.
Language: Английский
Citations
1
Pest Management Science, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 4, 2024
Abstract BACKGROUND The potential application of vanillin as a fungicide has garnered significant attention in the agricultural product market and food industries. Consequently, novel series derivatives containing thiazole hydrazone fragments were strategically designed, synthesized, evaluated for their antifungal activity against six representative plant phytopathogenic fungi. RESULTS In vitro assay, some title showed good Botrytis cinerea , Fusarium solani Magnaporthe grisea . Significantly, compound 4a exhibited remarkable broad‐spectrum fungistatic potency displayed most potent B. F. with half maximal effective concentration (EC 50 ) values 1.07 0.78 μg/mL, respectively, substantially surpassing efficacy commercial hymexazol comparable to carbendazim. addition, 4k selectively inhibited M. lowest EC value 7.77 μg/mL. vivo assay revealed that superior protective compared At same time, scanning electron microscopy (SEM), transmission (TEM), fluorescent dye staining exerted its fungicidal by damaging cell wall, membrane mitochondria cinerea. CONCLUSION Modification through electron‐withdrawing group substitution hydrophobic substitution, followed condensation thiazole‐4‐carbohydrazide, could result highly active derivatives. Among them, which excellent inhibitory activities potentially serve lead compound. © 2024 Society Chemical Industry.
Language: Английский
Citations
0
Journal of the Iranian Chemical Society, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0