4‐Octyl Itaconate Alleviates Myocardial Ischemia‐Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Myocardial ischemia‐reperfusion (IR) injury is a critical complication following revascularization therapy for ischemic heart disease. Itaconate, macrophage‐derived metabolite, has been implicated in inflammation and metabolic regulation. This study investigates the protective role of itaconate derivatives against IR injury. Using mice model injury, impact 7‐day 4‐Octyl (4‐OI) administration on cardiac function assessed. Exogenous 4‐OI significantly reduces myocardial damage, enhances angiogenesis, alleviates hypoxia during reperfusion. RNA sequencing molecular docking techniques are used to find target itaconate, changes observed Immune‐Responsive Gene1 (IRG1) global knockout mice. In cell culture studies, promotes endothelial proliferation migration, mediated by Mitogen‐Activated Protein Kinases (MAPK) signaling pathway activation, particularly through Extracellular Signal‐Regulated Kinase (ERK) signaling. Inhibition ERK blocks these beneficial effects cells. Furthermore, synthesis inhibition worsens which mitigated supplementation. The results indicate that angiogenesis activating MAPK via FMS‐like tyrosine kinase 1 (Flt1), highlighting its potential as therapeutic strategy

Language: Английский

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Cardioprotective potential of transcription factor PRRX1 silencing against myocardial ischemia/reperfusion injury by regulating excessive mitophagy and ferroptosis through FKBP5-p38 MAPK axis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(5), P. 167766 - 167766

Published: March 3, 2025

Language: Английский

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A Gelatin‐Based Bioadhesive Featuring Mechanically Induced Glue‐To‐Gel Transition

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract In the field of bioadhesives, development machinable adhesives with a “glue‐to‐gel transition” remains significant challenge. This study presents novel design strategy to endow Gel/Eg adhesive mechanical machinability. It leverages combination hydrogen bond interactions, metal complexation, and secondary structure gelatin through one‐step mixing method. Rheological analysis shows that exhibits frequency‐dependent transition,” maintaining glue state at low frequencies transitioning gel higher frequencies. During stretching, β‐sheet transforms into random coil structure. Moreover, features excellent water resistance, swelling ratio, strong adhesion strength, high extensibility, instantaneous adhesion, self‐healing, both biocompatibility hemocompatibility. These attributes enable exhibit multiple fault‐tolerance capabilities on tissue surfaces, highlighting its potential for diverse biomedical applications.

Language: Английский

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Exosome-Loaded Tannic Acid–Thioctic Acid Hydrogel Enhances Wound Healing in Coagulation Disorders

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101496 - 101496

Published: Jan. 25, 2025

Language: Английский

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Bioactive Matters based on Natural Product for Cardiovascular Diseases

Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(4), P. 542 - 565

Published: Nov. 16, 2024

Language: Английский

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Versatile poly (deep eutectic solvents) electroactive chitosan eutectogel for infected wound healing and monitoring administration

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 352, P. 123192 - 123192

Published: Dec. 25, 2024

Language: Английский

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