SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials DOI Creative Commons
Qian Cai, Rui Guo, Dafu Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Language: Английский

A nanotechnology driven effectual localized lung cancer targeting approaches using tyrosine kinases inhibitors: Recent progress, preclinical assessment, challenges, and future perspectives DOI

Ankaj Kumar,

Klaudi K. Vaiphei,

Arvind Gulbake

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124745 - 124745

Published: Sept. 1, 2024

Language: Английский

Citations

4
Macrophage-targeting nano-formulated bicalutamide alleviates colitis by inducing MAP3K1-mediated degradation of NLRP3 DOI
Suqin Zhong,

Suzhen Zhong,

Yi Wu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 417 - 432

Published: Feb. 10, 2025

Language: Английский

Citations

0
Applications, challenges, and future perspective of albumin in drug delivery DOI
Ankaj Kumar,

Akhila Reddy,

Adinath Dadhale

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 621 - 658

Published: Jan. 1, 2025

Language: Английский

Citations

0
QUERCETIN-LOADED GRAPHENE OXIDE NANOPARTICLES: SYNTHESIS, OPTIMIZATION, AND EVALUATION FOR BREAST CANCER TREATMENT DOI Open Access
PRASHANT S. TANDALE, Ashish Suttee,

Prakash Prabhakar

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 243 - 251

Published: May 7, 2025

Objective: This study aimed to develop graphene oxide (GO) nanoparticles (NPs) loaded with Quercetin (QUE) for oncological applications, enhancing therapeutic efficacy while minimizing adverse effects. Methods: QUE-GO NPs were synthesized using Tween 80 and probe sonication, optimization achieved through a Box-Behnken Design (BBD) that considered parameters including GO weight, surfactant volume, sonication time. Results: The optimized batch 14 an Entrapment Efficiency (EE) of 92.5±0.7%, particle size 86.9±0.46 nm Polydispersity Index (PDI) 0.158±0.001, indicating good stability. Drug release studies showed 88.60±2.3% over 8 h (n = 3). Cytotoxicity assays in MCF-7 breast cancer HEK293 noncancerous cells revealed enhanced cytotoxicity against (IC50: 126.20 µg/ml) (p<0.001) compared pure QUE's (MW: 302.24 g/mol) IC50 175.89 µg/ml (p<0.05). safety profile was observed HEK 293 1009.40 µg/ml). Conclusion: These findings support as promising nanocarrier targeted therapy. A favourable observed.

Language: Английский

Citations

0
SynBioNanoDesign: pioneering targeted drug delivery with engineered nanomaterials DOI Creative Commons
Qian Cai, Rui Guo, Dafu Chen

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Synthetic biology and nanotechnology fusion represent a transformative approach promoting fundamental clinical biomedical science development. In SynBioNanoDesign, biological systems are reimagined as dynamic programmable materials to yield engineered nanomaterials with emerging specific functionalities. This review elucidates comprehensive examination of synthetic biology's pivotal role in advancing for targeted drug delivery systems. It begins exploring the synergy between nanotechnology, then highlights current landscape applications. Subsequently, discusses design novel informed by principles, focusing on expounding tools potential developing advanced nanomaterials. Afterward, research advances innovative through were systematically summarized, emphasizing integration genetic circuitry program nanomaterial responses. Furthermore, challenges, weaknesses opportunities, prospective directions, ethical societal implications SynBioNanoDesign elucidated. Finally, summarizes impact that may have drug-delivery technologies future.

Language: Английский

Citations

0