Exploring the Potential of Gold Nanoparticles in Proton Therapy: Mechanisms, Advances, and Clinical Horizons

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 176 - 176

Published: Jan. 30, 2025

Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation tumors while sparing surrounding healthy tissues. Despite its clinical success, proton faces challenges optimizing therapeutic precision and efficacy. Recent research has highlighted potential gold nanoparticles enhance outcomes. Due their high atomic number favorable biological properties, act as radiosensitizers by amplifying generation secondary electrons reactive oxygen species upon irradiation. This enhances DNA damage tumor cells preserving Additionally, functionalization with tumor-targeting ligands offers improved precision, making more effective against broader range cancers. review synthesizes current knowledge on mechanisms nanoparticle radiosensitization, preclinical evidence, technological hurdles that must be addressed integrate this promising approach into practice, aiming advance efficacy accessibility therapy.

Language: Английский

Enhanced Efficacy and Bioavailability of Amikacin-Loaded Niosomal Nanovesicles Based on Low-HLB Amphiphiles: In Vitro/Ex Vivo/In Vivo Studies

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106709 - 106709

Published: Feb. 1, 2025

Language: Английский

Preparation and characterization of niosomes containing silver nanoparticles as a radiosensitizer for enhancing radiotherapy of the lung cancer

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 29, 2025

Language: Английский