Study on the Preparation of Multifunctional Bacterial Cellulose-Based Wound Dressings and Their In Vitro Hemostatic Performance
Abstract
Bacterial
cellulose
(BC)
is
a
favored
material
for
medical
wound
dressings
due
to
its
biocompatibility
and
water-holding
capacity,
yet
it
lacks
inherent
antibacterial
hemostatic
capabilities.
To
enhance
functionality,
novel
BC-based
dressing
(HBP)
was
engineered
by
integrating
chitosan
quaternary
ammonium
salt
(HACC)
hydroxyapatite
(HAP)
into
BC's
3D
structure
via
soaking,
stirring,
freeze-drying
techniques.
This
composite
demonstrates
significant
activity,
evidenced
distinct
inhibition
zones
in
antimicrobial
assays,
rapid
performance,
with
an
vitro
clotting
time
of
300
±
5
seconds.
Characterized
using
SEM,
XRD,
FT-IR,
XPS,
HBP
exhibits
superior
physicochemical
characteristics
biocompatibility,
positioning
as
highly
viable
option
advanced
biomedical
dressings.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Language: Английский