Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Progress of metal-organic frameworks in improving the effect of sonodynamic therapy DOI Creative Commons
Qiang Cai, Jine Wang,

Ruhui Yan

et al.

Biomedical Technology, Journal Year: 2025, Volume and Issue: 9, P. 100070 - 100070

Published: Feb. 14, 2025

Language: Английский

Citations

0
Development and Application of Organic Sonosensitizers in Cancer Therapy DOI Creative Commons
Yuhan Ding,

Yuchen Yang,

Ömer Aras

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

Citations

0