Genetic and Epigenetic Association of FOXP3 with Papillary Thyroid Cancer Predisposition DOI Open Access
Charoula Achilla, Angeliki Chorti,

Theodosios Papavramidis

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7161 - 7161

Published: June 28, 2024

Papillary thyroid cancer (PTC) is the most common type of malignancy with an increased female incidence ratio. The specific traits X chromosome inheritance may be implicated in gender differences PTC predisposition. aim this study was to investigate association two X-linked genes, Forkhead Box P3 (FOXP3) and Protein Phosphatase 1 Regulatory Subunit 3F (PPP1R3F), predisposition disparity. One hundred thirty-six patients equal number matched healthy volunteers were enrolled study. Genotyping for rs3761548 rs5953283 (PPP1R3F) performed using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). methylation status FOXP3 assessed combined bisulfite restriction analysis (COBRA) method. SPSS software used statistical analyses. Gender stratification revealed that CA AA genotypes A allele variant are associated only females. Moreover, different observed up promoter locus between patients, carrying CC genotype, controls. Both associations explain higher females through reducing expression as reported immune related blood cells.

Language: Английский

T-helper Transcription Factor Profiling in Peripheral Blood Mononuclear Cells: A Non-invasive Approach to Predicting Disease Stage in Breast Cancer DOI
Maryam Rezaee,

Fatemeh Kheiri,

Fatemeh Faraji

et al.

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

Citations

0
3-O-acetyl-11-keto-beta-boswellic acid (β-AKBA) and 11-keto-beta-boswellic acid (β-KBA) increase FoxP3 expression in CD4+ T regulatory cells DOI

Abdo Meyiah,

Ahmed Al-Harrasi,

Najeeb Ur Rehman

et al.

Fitoterapia, Journal Year: 2025, Volume and Issue: 184, P. 106641 - 106641

Published: May 27, 2025

Language: Английский

Citations

0
Genetic and Epigenetic Association of FOXP3 with Papillary Thyroid Cancer Predisposition DOI Open Access
Charoula Achilla, Angeliki Chorti,

Theodosios Papavramidis

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7161 - 7161

Published: June 28, 2024

Papillary thyroid cancer (PTC) is the most common type of malignancy with an increased female incidence ratio. The specific traits X chromosome inheritance may be implicated in gender differences PTC predisposition. aim this study was to investigate association two X-linked genes, Forkhead Box P3 (FOXP3) and Protein Phosphatase 1 Regulatory Subunit 3F (PPP1R3F), predisposition disparity. One hundred thirty-six patients equal number matched healthy volunteers were enrolled study. Genotyping for rs3761548 rs5953283 (PPP1R3F) performed using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). methylation status FOXP3 assessed combined bisulfite restriction analysis (COBRA) method. SPSS software used statistical analyses. Gender stratification revealed that CA AA genotypes A allele variant are associated only females. Moreover, different observed up promoter locus between patients, carrying CC genotype, controls. Both associations explain higher females through reducing expression as reported immune related blood cells.

Language: Английский

Citations

2