4D printing for biomedical applications

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(12), P. 2985 - 3005

Published: Jan. 1, 2024

Schematic illustration of 4D printing.

Language: Английский

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Harnessing the power of artificial intelligence for human living organoid research

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 140 - 164

Published: Aug. 30, 2024

As a powerful paradigm, artificial intelligence (AI) is rapidly impacting every aspect of our day-to-day life and scientific research through interdisciplinary transformations. Living human organoids (LOs) have great potential for

Language: Английский

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Facilitation of Tumor Stroma-Targeted Therapy: Model Difficulty and Co-Culture Organoid Method

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 62 - 62

Published: Jan. 8, 2025

Background: Tumors, as intricate ecosystems, comprise oncocytes and the highly dynamic tumor stroma. Tumor stroma, representing non-cancerous non-cellular composition of microenvironment (TME), plays a crucial role in oncogenesis progression, through its interactions with biological, chemical, mechanical signals. This review aims to analyze challenges stroma mimicry models, highlight advanced personalized co-culture approaches for recapitulating using patient-derived organoids (PDTOs). Methods: synthesizes findings from recent studies on composition, stromal remodeling, spatiotemporal heterogeneities TME. It explores popular stroma-related systems integrating PDTOs elements, techniques improve mimicry. Results: Stroma driven by cells, highlights dynamism heterogeneity PDTOs, derived tissues or cancer-specific stem accurately mimic tissue-specific genetic features primary tumors, making them valuable drug screening. Co-culture models combining elements effectively recreate TME, showing promise anti-cancer therapy. Advanced flexible combinations enhance precision tumor-stroma recapitulation. Conclusions: PDTO-based offer promising platform therapy development. underscores importance refining these advance medicine therapeutic outcomes.

Language: Английский

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Photo-Crosslinking Hydrogel Based on Porcine Small Intestinal Submucosa Decellularized Matrix/Fish Collagen/GelMA for Culturing Small Intestinal Organoids and Repairing Intestinal Defects

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 663 - 663

Published: Jan. 14, 2025

Organoid technology, as an innovative approach in biomedicine, exhibits promising prospects disease modeling, pharmaceutical screening, regenerative medicine, and oncology research. However, the use of tumor-derived Matrigel primary method for culturing organoids has significantly impeded clinical translation organoid technology due to concerns about potential risks, batch-to-batch instability, high costs. To address these challenges, this study innovatively introduced a photo-crosslinkable hydrogel made from porcine small intestinal submucosa decellularized matrix (SIS), fish collagen (FC), methacrylate gelatin (GelMA). The cost-effective demonstrated excellent biocompatibility, tunable mechanical properties, rapid gelation low immunogenicity. Importantly, proliferation differentiation capacities cultured were comparable those Matrigel, with no significant disparity observed. Furthermore, after one week transplantation nude mice, hydrogel-organoid complex exhibited sustained structural functional stability while preserving characteristics organoids. Our also effective FC/SIS/GelMA accelerating repair process defects, reducing area scar formation, promoting regeneration both villi smooth muscle tissue. In summary, presents novel protocol organoids, offering implications future applications serving experimental foundation development tissue-engineered intestines based on

Language: Английский

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Recent advances in 3D food printing: Therapeutic implications, opportunities, potential applications, and challenges in the food industry

Food Research International, Journal Year: 2025, Volume and Issue: 203, P. 115791 - 115791

Published: Jan. 20, 2025

Language: Английский

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3D printed arrowroot starch-gellan scaffolds for wound healing applications

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130604 - 130604

Published: March 5, 2024

Language: Английский

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A Review on 3D Printing Processes in Pharmaceutical Engineering and Tissue Engineering: Applications, Trends and Challenges

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: July 9, 2024

Abstract As a 3D rapid prototyping technology, printing (3DP) technology has been widely applied in medical research, fabricating various devices or implants. With the development of biomaterials and cell‐related technologies, 3DP, especially bioprinting is quietly bringing great changes opportunities industry. Beyond surgical models, devices, implants, traditional cell‐based bioprinting, emerging 4D (4DP) have significantly aided advancement manufacture pharmaceuticals biological alternatives for tissue engineering. It envisioned that future healthcare systems, based on evolving 3DP precision medicine, will deliver customized solutions cater to unique differences needs each patient. In this review work, several mainstream technologies are presented, with focus recent advances pharmaceutical engineering important engineering, including vascular bone Challenges prospects drug discovery, delivery artificial blood vessels, scaffolds, practical applications also covered. Finally, between 4DP, as well advantages disadvantages different stimulus response mechanisms 4DP their potential summarized.

Language: Английский

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3D‐Printed Polymeric Biomaterials for Health Applications

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Abstract 3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health‐related devices. With advancements in polymer chemistry biomedical engineering, polymeric biomaterials have become integral to 3D‐printed applications. However, there still exists a bottleneck the compatibility with different printing methods, well intrinsic challenges such limited resolution rates. Therefore, this review aims introduce current state‐of‐the‐art It begins an overview landscape techniques, followed by examination commonly used biomaterials. Subsequently, examples devices are provided classified into categories biosensors, bioactuators, soft robotics, energy storage systems, self‐powered devices, data science bioplotting. The emphasis is on exploring capabilities manufacturing desired geometries that facilitate device functionality studying reasons material choice. Finally, outlook possible improvements near future presented, projecting contribution general field healthcare.

Language: Английский

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Applications of 3D organoids in toxicological studies: a comprehensive analysis based on bibliometrics and advances in toxicological mechanisms

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(8), P. 2309 - 2330

Published: May 28, 2024

Language: Английский

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Advances in skin-mimetic platforms: A comprehensive review of drug permeation models

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 98, P. 105887 - 105887

Published: June 15, 2024

Language: Английский

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