Microbial Consortium of Jeju Traditional Fermented Foods and Their Cosmetic Ingredient Potential DOI Creative Commons

Sung-Eun Bae,

Sung Min Bae, Sung Jin Park

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(7), P. 345 - 345

Published: July 1, 2024

In this study, we analyzed the microbial community of traditional fermented foods Jeju Island to identify distribution useful microorganisms and confirm their anti-inflammatory anti-melanogenic effects determine potential use as cosmetic ingredients. Firstly, examined communities Omphalius rusticus Jeotgal (OR), Spratelloides gracilis (SG), Chromis notata (CN), Turbo cornutus (TC), Trichiurus lepturus intestine (TL), Branchiostegus japonicus Sweet Rice Punch (BJ), Salted Anchovy Sauce (SA), Soy (JSS), Soybean Paste (JSP). We found that Latilactobacillus sakei (87.2%), Tetragenococcus halophilus (37.7%), T. (96.8%), Bacillus subtilis (23.4%), (71.3%), L. (53.7%), Lentibacillus sp. (42.9%), Enterococcus durans (14.6%), E. (32.8%) were dominant species. Secondly, study nine foods’ effects, employed RAW 264.7 B16F10 cells, classic cell models for inflammation melanogenesis studies. Ethyl acetate extracts all inhibited nitric oxide (NO) melanin production in a concentration-dependent manner. Thirdly, test applicability human skin, used MTT assay assess cytotoxic on keratinocytes (HaCaT cells). Finally, topical was tested through primary skin irritation, it they did not cause any adverse effects. Therefore, from have applications ingredients products can be industry.

Language: Английский

Advances in next-generation sequencing (NGS) applications in drug discovery and development DOI
Huihong Wang,

Jiale Huang,

Xianfu Fang

et al.

Expert Opinion on Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Drug discovery is a complex and multifaceted process driven by scientific innovation advanced technologies. Next-Generation Sequencing (NGS) platforms, encompassing both short-read long-read technologies, have revolutionized the field enabling high-throughput cost-effective analysis of DNA RNA molecules. Continuous advancements in NGS-based technologies enabled their seamless integration across preclinical clinical workflows drug discovery, early-stage target identification, candidate selection, genetically stratified trials, pharmacogenetic studies. This review provides an overview current potential applications development process, including roles novel screening, medication The based on literature retrieval from PubMed Web Science databases between 2018 2024. As advance rapidly, NGS enhances accuracy generates vast datasets. These datasets are extensively integrated with other heterogeneous data systems biology mined using machine learning to extract significant insights, thereby driving progress discovery.

Language: Английский

Citations

0
Microbial Consortium of Jeju Traditional Fermented Foods and Their Cosmetic Ingredient Potential DOI Creative Commons

Sung-Eun Bae,

Sung Min Bae, Sung Jin Park

et al.

Fermentation, Journal Year: 2024, Volume and Issue: 10(7), P. 345 - 345

Published: July 1, 2024

In this study, we analyzed the microbial community of traditional fermented foods Jeju Island to identify distribution useful microorganisms and confirm their anti-inflammatory anti-melanogenic effects determine potential use as cosmetic ingredients. Firstly, examined communities Omphalius rusticus Jeotgal (OR), Spratelloides gracilis (SG), Chromis notata (CN), Turbo cornutus (TC), Trichiurus lepturus intestine (TL), Branchiostegus japonicus Sweet Rice Punch (BJ), Salted Anchovy Sauce (SA), Soy (JSS), Soybean Paste (JSP). We found that Latilactobacillus sakei (87.2%), Tetragenococcus halophilus (37.7%), T. (96.8%), Bacillus subtilis (23.4%), (71.3%), L. (53.7%), Lentibacillus sp. (42.9%), Enterococcus durans (14.6%), E. (32.8%) were dominant species. Secondly, study nine foods’ effects, employed RAW 264.7 B16F10 cells, classic cell models for inflammation melanogenesis studies. Ethyl acetate extracts all inhibited nitric oxide (NO) melanin production in a concentration-dependent manner. Thirdly, test applicability human skin, used MTT assay assess cytotoxic on keratinocytes (HaCaT cells). Finally, topical was tested through primary skin irritation, it they did not cause any adverse effects. Therefore, from have applications ingredients products can be industry.

Language: Английский

Citations

2