The role of urinary microbiota in primary and recurrent bladder cancer: insights from a propensity score matching study DOI Creative Commons
Zhuping Sheng,

Jinshan Xu,

Maoyu Wang

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 14, 2025

Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder (NMIBC), posing significant clinical challenges. Emerging evidence links microbiota to progression; however, their role BCa remains unclear. This study aimed explore differences between primary and recurrent identify potential microbiological markers mechanisms associated recurrence. Urine samples were collected from 170 patients, including 125 Bca(BCa_P) 45 (BCa_R). All underwent 16 S rRNA gene sequencing, data collected, age, sex, body mass index (BMI), smoking history, pathological grade, other biological characteristics. Propensity score matching (1:1 ratio, caliper = 0.02) minimized baseline differences, resulting 39 matched pairs. Microbial diversity was analyzed using α β indices. Differential taxa identified Linear Discriminant Analysis Effect Size (LEfSe), functional pathways predicted Phylogenetic Investigation of Communities by Reconstruction Unobserved States (PICRUSt). Alpha significantly higher BCa_P than BCa_R, particularly Chao1 revealed distinct microbial structures (ADONIS, P 0.004, R² 0.025). At the phylum level, both BCa_R dominated Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Firmicutes Bacteroidetes lower BCa_R. genus enriched Sphingomonas, Corynebacterium, Capnocytophaga, Massilia, Aquabacterium, while showed levels Aeromonas, Cupriavidus, Bradyrhizobium. Functional predictions glucose metabolism oxidative stress pollutant degradation TCA cycle prominent BCa_P. These findings reveal compositions profiles cases exhibiting reduced enrichment potentially pathogenic communities, highlighting roles tumor progression Registered Chinese Clinical Trial Registry (ChiCTR2300070969) on April 27, 2023.

Language: Английский

Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges DOI
Babak Pezeshki, Hussein T. Abdulabbas, Asma M. Alturki

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
The role of urinary microbiota in primary and recurrent bladder cancer: insights from a propensity score matching study DOI Creative Commons
Zhuping Sheng,

Jinshan Xu,

Maoyu Wang

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 14, 2025

Bladder cancer (BCa) is a common urinary malignancy with high recurrence rates in non-muscle invasive bladder (NMIBC), posing significant clinical challenges. Emerging evidence links microbiota to progression; however, their role BCa remains unclear. This study aimed explore differences between primary and recurrent identify potential microbiological markers mechanisms associated recurrence. Urine samples were collected from 170 patients, including 125 Bca(BCa_P) 45 (BCa_R). All underwent 16 S rRNA gene sequencing, data collected, age, sex, body mass index (BMI), smoking history, pathological grade, other biological characteristics. Propensity score matching (1:1 ratio, caliper = 0.02) minimized baseline differences, resulting 39 matched pairs. Microbial diversity was analyzed using α β indices. Differential taxa identified Linear Discriminant Analysis Effect Size (LEfSe), functional pathways predicted Phylogenetic Investigation of Communities by Reconstruction Unobserved States (PICRUSt). Alpha significantly higher BCa_P than BCa_R, particularly Chao1 revealed distinct microbial structures (ADONIS, P 0.004, R² 0.025). At the phylum level, both BCa_R dominated Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Firmicutes Bacteroidetes lower BCa_R. genus enriched Sphingomonas, Corynebacterium, Capnocytophaga, Massilia, Aquabacterium, while showed levels Aeromonas, Cupriavidus, Bradyrhizobium. Functional predictions glucose metabolism oxidative stress pollutant degradation TCA cycle prominent BCa_P. These findings reveal compositions profiles cases exhibiting reduced enrichment potentially pathogenic communities, highlighting roles tumor progression Registered Chinese Clinical Trial Registry (ChiCTR2300070969) on April 27, 2023.

Language: Английский

Citations

0