Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma DOI Creative Commons
Xue Wang, Shanshan Ma,

Shuting Zhu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 225 - 225

Published: Jan. 17, 2025

Malignant melanoma (MM) is a malignant tumor, resulting from mutations in melanocytes of the skin and mucous membranes. Its mortality rate accounts for 90% all dermatologic tumor mortality. Traditional treatments such as surgery, chemotherapy, radiotherapy are unable to achieve expected results due MM's low sensitivity, high drug resistance, toxic side effects. As treatment advances, immunotherapy targeted therapy have made significant breakthroughs MM demonstrated promising application prospects. However, heterogeneity immune response causes more than half patients not benefit clinical therapy, which delays patient's condition them suffer adverse events' The combination can help improve therapeutic effects, delay mitigate This review provides comprehensive overview current development status research progress checkpoints, genes, their inhibitors, with view providing reference MM.

Language: Английский

Advances in Immunotherapy and Targeted Therapy of Malignant Melanoma DOI Creative Commons
Xue Wang, Shanshan Ma,

Shuting Zhu

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 225 - 225

Published: Jan. 17, 2025

Malignant melanoma (MM) is a malignant tumor, resulting from mutations in melanocytes of the skin and mucous membranes. Its mortality rate accounts for 90% all dermatologic tumor mortality. Traditional treatments such as surgery, chemotherapy, radiotherapy are unable to achieve expected results due MM's low sensitivity, high drug resistance, toxic side effects. As treatment advances, immunotherapy targeted therapy have made significant breakthroughs MM demonstrated promising application prospects. However, heterogeneity immune response causes more than half patients not benefit clinical therapy, which delays patient's condition them suffer adverse events' The combination can help improve therapeutic effects, delay mitigate This review provides comprehensive overview current development status research progress checkpoints, genes, their inhibitors, with view providing reference MM.

Language: Английский

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