Impressive stability-indicating RP-HPLC method for concurrent quantification of salbutamol, guaifenesin, and sodium benzoate in cough syrup: Application of six sigma and green metrics

Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 1, 2025

Abstract Analytical chemistry research has shifted towards environmentally friendly substitutes that reduce waste and avoid hazardous substances. These efforts align with broader environmental goals inspire sustainable responsible science. The objective of this work is to develop validate an analytical method verify its greenness using specific tools, including GREEnness (AGREE), metric for sample preparation (AGREEprep), green procedure index, complex Eco-Scale, volume intensity, score, HPLC-EAT (Environmental Assessment Tool). Effective treatment chronic cough relies heavily on adequately utilizing salbutamol (SAL) guaifenesin (GUA) in the presence sodium benzoate (SOB) preservative. isocratic elution mode used Zorbax Eclipse Plus C18 column (15 cm × 4.6 mm, 3.5 µm). It could move 1.5 mL·min −1 , hold 50 µL, have a temperature 30°C, autosampler 5°C. detect UV light at 276 nm had mobile phase 80:20 v/v buffer solution acetonitrile. We successfully established highly accurate calibration curves three components SAL, GUA, SOB within optimal range 2–50 µg·mL . coefficient correlation ( r ) these was impressive 0.9999 SAL while it 0.9998 SOB. recovery values were 100.15%, 100.47%, 100.92% SOB, respectively. selectivity sensitivity ingredients confirmed according International Council Harmonisation guidelines, as no interference occurred from any components. implemented Six Sigma, resulting precision productivity.

Language: Английский

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Quantitative analysis of quaternary mixtures in topical creams using cutting-edge HPLC technique: environmental impact and sigma methodology

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 20, 2025

Language: Английский

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Strategic Approaches to Elevate Quality and Sustainability in Drug Development: Comprehensive Pretomanid (PA-824) Chemical Stability study using QbD and Green Chemistry Principles

Microchemical Journal, Journal Year: 2024, Volume and Issue: 200, P. 110413 - 110413

Published: March 26, 2024

Language: Английский

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Cutting‐edge HPLC and MCR techniques for synchronically quantifying anticholinergic drugs in the presence of C12 and C14 homologs: Robust application to green and white chemistry

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 357(9)

Published: June 18, 2024

Green and white chemistry are vital to revolutionizing the chemical industry through their unparalleled potential enhance sustainability efficiency. In this study, nine tools of both green metrics, including analytical procedure index (GAPI), ComplexGAPI, greenness, greenness metric for sample preparation, Analytical Eco-Scale (ESA), method score, high-performance liquid chromatography- environmental assessment tool (HPLC-EAT), volume intensity, blue applicability grade (BAGI), have been developed appraising friendliness innovative straightforward mean centering ratio spectra (MCR) reversed-phase chromatography (RP-HPLC) strategies utilized concurrent analysis separation cyclopentolate (CYC) C12 C14 homologs benzalkonium chloride (BNZ) in pure ophthalmic solution. The mobile phase, formed buffer phosphate acetonitrile (35:65, v/v), was adjusted pH 6.3, 215-nm UV detection used. experimental flow rate 2.0 mL min

Language: Английский

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Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach

Green Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 100211 - 100211

Published: Jan. 1, 2025

Language: Английский

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Integrating Quality by Design and Green Chemistry for Sustainable Drug Development: Acalabrutinib Stability Study

Chromatographia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Micellar HPLC and UV Methods with Time Programming for Synchronically Quantifying Gatifloxacin and Its Preservative in Eye Drops: Appraisal of Ecological Impact

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Modern society is increasingly reliant on sustainable solutions. We suggest a creative study that meets the standards of sustainability in analytical chemistry. The objective to promote eco-friendly methods for concurrently detecting Gatifloxacin (GAT) and benzalkonium chloride (BEN) ocular Using sustained mobile phase flow rate 0.8 mL/min-1 acidic water: 10% 1-butanol water (40:60, v/v), GAT was retained 2.242 min at 287 nm, followed by BEN homologues 215 nm next 2.982 4.201 min. This process simple, quick, precise. method demonstrated peak symmetry, low processing times, good resolution, correlation values 0.999. For GAT, linearity ranged from 0.001 0.023 mgmL-1, while BEN, it 0.003 0.060 mgmL-1 HPLC system, UV range 0.005-0.03 all drugs. A unique feature this integration multiple assessment tools, such as AGREE, AGREEprep, ComplexGAPI, ESA, BAGI, NEMI pictograms, providing an exhaustive appraisal methods' environmental impact enhancing robustness findings. In addition, cost-effective alternatives were explored using solvent complementary spectrophotometric procedures mean centering ratio spectra (MCR). Each technique showed respectable accuracy precision (RSD ≤ 2%) high r2 > 0.9990. proposed methodologies provide inexpensive, conventional approaches, promoting less harmful future quality control moving chemistry closer more methods.

Language: Английский

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State-of-the-art mean centering of ratio spectra and HPLC methodologies for comprehensive analysis of some dry eyes drugs: investigation of white and green practices

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 4, 2025

Language: Английский

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Ultra-performance liquid chromatography method for quantitative analysis of nystatin and triamcinolone acetonide in topical creams after in vitro release using franz diffusion cell

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 19, 2025

The accurate quantification of active ingredients in topical creams is critical for ensuring efficacy, safety, and quality. Therefore, this initiative to develop validate a robust ultra-performance liquid chromatography (UPLC) method the nystatin (Nys) triamcinolone acetonide (TA) creams. Validation vitro release test (IVRT) apparatus UPLC was conducted according standard requirements. IVRT demonstrated exceptional control over key parameters, aligning with stringent standards, thus consistent reproducible drug profiles. Membrane inertness evaluation confirmed no significant binding Nys TA. proposed found be linear range 0.65–31.93 µg/mL TA 17.67-863.27 IU/mL determination coefficients 1.0000 both drugs, enabling measurement across wide concentrations. Recovery rates mass balance results were within acceptable ranges, validating method's accuracy. exhibited low day-1 day-2 variability, underscoring its reliability. Sensitivity specificity comparable similar studies, demonstrating applicability distinguishing between different formulation strengths variations. robustness by resistance variations dose amount, receptor media composition, stirring speed (stirring controlled rotation controller connected vertical diffusion cell Instrument. Material construction plastic, plastic bead helix spring placed uniform mixing.), temperature. validation affirmed high sensitivity reliability detecting levels ingredients, excellent selectivity, specificity, linearity, precision, accuracy, stability, robustness. equipment's analytical thorough certification procedures verify fit precise dependable cream compositions. These techniques satisfy all scientific legal criteria. Not Applicable.

Language: Английский

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Green RP-HPLC method for simultaneous quantification of epigallocatechin-3-gallate and rosmarinic acid in lipid-based nanocarriers and biological fluids: Quality by Design-driven optimization and lean six sigma approach

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: 11, P. 100153 - 100153

Published: Sept. 14, 2024

Language: Английский

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