Relationship between nutritional-inflammatory markers and postoperative outcomes in ovarian cancer: a retrospective study

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 11, 2025

Background Elevated inflammatory markers are commonly linked to poor prognoses in cancer patients, while optimal nutritional status correlates with improved survival outcomes. This study aimed explore the interplay between and their impact on postoperative outcomes ovarian patients through a retrospective analysis. Methods Data were retrospectively retrieved from diagnosed who required surgical intervention at Department of Obstetrics Gynecology. Overall (OS) cancer-specific (CSS) monitored during follow-up. Kaplan-Meier curves employed assess OS CSS across different patient cohorts, evaluating prognostic significance markers. Nomograms for predicting one, three, five years postoperatively constructed, followed by external validation. Results The index (PNI) Naples score (NPS) exhibited significant correlation ( p < 0.05). Analysis indicated that PNI > 51.2 demonstrated most favorable Furthermore, those low-NPS (L-NPS) had notably better rates compared high-NPS (H-NPS) counterparts. Independent predictors included age, PNI, NPS, histological type, tumor size, targeted therapy, diabetes. Similarly, prediction model incorporated nomograms robust predictive accuracy three- five-year survival, though one-year calibration showed limited agreement. Despite slightly reduced validation performance initial sample, maintained strong capability. Conclusions serves as key independent marker patients. based NPS provide valuable insights management. Incorporating these indices into clinical practice could improve stratification guide personalized treatment plans.

Language: Английский

Prognostic significance of preoperative Naples prognostic score for disease-free and overall survival in oral cavity squamous cell carcinoma post-surgery

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Oral cavity squamous cell carcinoma (OCSCC) is a common malignancy with high morbidity and mortality. This research seeks to assess the correlation between Naples Prognostic Score (NPS) survival outcomes in patients OCSCC who are receiving surgical treatment, highlighting its potential as prognostic tool for predicting patient outcomes. retrospective study included 589 from two large regional medical centers central China, treated February 2008 September 2019. Inclusion criteria mandated confirmed diagnosis, age ≥ 18 years, radical surgery, while distant metastasis, multiple tumors, or insufficient data were excluded. Data on 29 clinicopathological variables, including demographic details, tumor characteristics, nutritional/inflammatory markers, collected. The statistical approach both univariate multivariate Cox regression models determine factors associated disease-free (DFS) overall (OS). Additionally, Kaplan-Meier analysis was employed evaluate effect of adjuvant radiotherapy various NPS subgroups. Surgical margin status, ENE, NPS, age-adjusted Charlson comorbidity index (ACCI), American Joint Committee Cancer (AJCC) stage identified independent DFS. Similarly, Eastern Cooperative Oncology Group Performance Status (ECOG PS), extranodal extension (ENE), ACCI, AJCC found be OS. A higher poorer prognosis. In III-IVb 1-2, significantly improved DFS Likewise, 3-4, better OS However, no significant impact observed I-II those 0, regardless stage. underscores importance stratifying therapy. beneficial indicator patients. Its integration into clinical practice may assist risk stratification treatment decision-making, particularly undergoing radiotherapy.

Language: Английский