PROTAC Technology as a New Tool for Modern Pharmacotherapy DOI Creative Commons

Natalia Kubryń,

Łukasz Fijałkowski, Jacek Nowaczyk

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2123 - 2123

Published: May 11, 2025

The publication focuses on the innovative applications of PROTAC (proteolysis-targeting chimera) technology in modern pharmacotherapy, with particular emphasis cancer treatment. PROTACs represent an advanced therapeutic strategy that enables selective protein degradation, opening new possibilities drug design. This shows potential treatment cancers, viral infections (such as HIV and COVID-19), chronic diseases including atherosclerosis, Alzheimer’s disease, atopic dermatitis, Huntington’s disease. Promising results from clinical studies compound ARV-471 confirm effectiveness this approach. New types PROTACs, like TF-PROTAC PhosphoTAC, are designed to enhance effectiveness, stability, absorption drugs. conclusions review highlight broad various their relevance for future therapies, particularly oncology.

Language: Английский

Key advances and application prospects of PROTAC technologies in the next 5 years DOI
Shuanglin Qin, Xiaohe Xiao

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 3

Published: May 2, 2025

Language: Английский

Citations

0
PROTAC Technology as a New Tool for Modern Pharmacotherapy DOI Creative Commons

Natalia Kubryń,

Łukasz Fijałkowski, Jacek Nowaczyk

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2123 - 2123

Published: May 11, 2025

The publication focuses on the innovative applications of PROTAC (proteolysis-targeting chimera) technology in modern pharmacotherapy, with particular emphasis cancer treatment. PROTACs represent an advanced therapeutic strategy that enables selective protein degradation, opening new possibilities drug design. This shows potential treatment cancers, viral infections (such as HIV and COVID-19), chronic diseases including atherosclerosis, Alzheimer’s disease, atopic dermatitis, Huntington’s disease. Promising results from clinical studies compound ARV-471 confirm effectiveness this approach. New types PROTACs, like TF-PROTAC PhosphoTAC, are designed to enhance effectiveness, stability, absorption drugs. conclusions review highlight broad various their relevance for future therapies, particularly oncology.

Language: Английский

Citations

0