The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer DOI Creative Commons
Thomas N. Seyfried,

Derek C. Lee,

Tomás Duraj

et al.

Journal of Bioenergetics and Biomembranes, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Otto Warburg originally proposed that cancer arose from a two-step process. The first step involved chronic insufficiency of mitochondrial oxidative phosphorylation (OxPhos), while the second protracted compensatory energy synthesis through lactic acid fermentation. His extensive findings showed oxygen consumption was lower lactate production higher in cancerous tissues than non-cancerous tissues. considered both and extracellular as accurate markers for ATP OxPhos glycolysis, respectively. Warburg’s hypothesis challenged showing remained high some cells despite elevated suggesting largely unimpaired. New information indicates neither nor are surrogates quantification cells. also did not know significant amount could come glutamine-driven substrate level glutaminolysis pathway with succinate produced end product, thus confounding linkage to origin within mitochondria. Moreover, new shows cytoplasmic lipid droplets aerobic fermentation biomarkers insufficiency. original can now be linked more complete understanding how underlies dysregulated cell growth. These address several questionable assumptions regarding allowing field advance effective therapeutic strategies less toxic metabolic management prevention cancer.

Language: Английский

Malignant Tumors in Vagal-innervated Organs: Exploring Its Homeostatic Role DOI
Pierrick Martinez, Jean‐Marc Sabatier

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217539 - 217539

Published: Feb. 1, 2025

Language: Английский

Citations

2
Rethinking corticosteroids use in oncology DOI Creative Commons
Pierrick Martinez, Jean‐Marc Sabatier

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Corticosteroids (CSs), widely used in oncology for their anti-inflammatory and immunosuppressive properties, help manage cancer-related symptoms side effects. However, long-term use may negatively affect patient survival exacerbate tumor progression. Elevated glucose glutamine metabolism, disruption of vitamin D levels, alterations the microbiome are some key factors contributing to these adverse outcomes. Approaches such as ketogenic diets, fasting, sartans, supplementation have shown promise providing similar benefits CSs while mitigating risks associated with mechanisms identified This perspective underscores necessity a reevaluation cancer care advocates further research into safer, more effective therapeutic strategies.

Language: Английский

Citations

0
The Warburg hypothesis and the emergence of the mitochondrial metabolic theory of cancer DOI Creative Commons
Thomas N. Seyfried,

Derek C. Lee,

Tomás Duraj

et al.

Journal of Bioenergetics and Biomembranes, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Otto Warburg originally proposed that cancer arose from a two-step process. The first step involved chronic insufficiency of mitochondrial oxidative phosphorylation (OxPhos), while the second protracted compensatory energy synthesis through lactic acid fermentation. His extensive findings showed oxygen consumption was lower lactate production higher in cancerous tissues than non-cancerous tissues. considered both and extracellular as accurate markers for ATP OxPhos glycolysis, respectively. Warburg’s hypothesis challenged showing remained high some cells despite elevated suggesting largely unimpaired. New information indicates neither nor are surrogates quantification cells. also did not know significant amount could come glutamine-driven substrate level glutaminolysis pathway with succinate produced end product, thus confounding linkage to origin within mitochondria. Moreover, new shows cytoplasmic lipid droplets aerobic fermentation biomarkers insufficiency. original can now be linked more complete understanding how underlies dysregulated cell growth. These address several questionable assumptions regarding allowing field advance effective therapeutic strategies less toxic metabolic management prevention cancer.

Language: Английский

Citations

0