Risk Factors of Human Mpox (Monkeypox) Infection: A Systematic Review and Meta-Analysis DOI Creative Commons
Chigozie Louisa J. Ugwu, Nicola Luigi Bragazzi, Jian Wu

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Background Mpox (formerly Monkeypox) virus has affected the lives of thousands individuals both in endemic and non-endemic countries. Before May 2022 outbreak, infections were sporadically Central Western Africa, still research into been limited lacking epidemiological data. Thus, identification potential risk factors to better understand who is at being infected critical for future prevention control. Objective To synthesize comprehensive evidence on associated with human transmission countries from inception March 31, 2024. Methods The Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines followed conducting systematic review. Electronic databases searched. Two reviewers sifted articles that included review: firstly, by title abstract, secondly, full text. We used Newcastle-Ottawa Scale (NOS) assess bias articles. Fixed or random effects meta-analysis conducted when least two studies reported odds ratios (OR), relative risks (RR), 95% confidence intervals (CI). Heterogeneity was assessed using I 2 statistic sensitivity analysis also done. study protocol registered under PROSPERO ID: CRD42023459895 . Results 947 identified database search 31 eligible be findings showed interaction animals ( OR = 5.61, CI 2.83, 11.13), HIV 4.46, 3.27, 6.08), other STIs 1.76, 1.42, 2.91), sexual contact/activities (OR 1.53, 1.13, 4.82), contact an person 2.39, 95%CI 1.87, 3.05), as men have sex (MSM) 2.18, 1.88, 2.51), having multiple partners 1.61, 1.24, 2.09), increased contracting Mpox. However, patients vaccinated against smallpox had a lower infection 0.24, 0.11, 0.55). Conclusion This first Our demonstrated certain Mpox, whereas vaccination protective role could facilitate strategic public health planning targeted intervention. Key messages this article What already known topic (monkeypox) zoonotic infectious disease notable global importance due recent outbreaks Prior travel areas animals, close lesions, particularly among household members. adds add body efforts assist intervention revealed strong correlation between infection, HVI, STIs, physical contacts, MSM. While may factor lesions STIs. How might affect research, practice policy results review provide support policymakers based factors.

Language: Английский

Risk factors associated with human Mpox infection: a systematic review and meta-analysis DOI Creative Commons
Chigozie Louisa J. Ugwu, Nicola Luigi Bragazzi, Jian Wu

et al.

BMJ Global Health, Journal Year: 2025, Volume and Issue: 10(2), P. e016937 - e016937

Published: Feb. 1, 2025

Background Mpox emerged as a significant global public health concern during the 2022–2023 outbreak, impacting populations in both endemic and non-endemic countries. This study reviews synthesises evidence on risk factors associated with human transmission across these regions. Methods A systematic search of peer-reviewed original studies was conducted Scopus, Embase, Web Science PubMed databases, covering publications up to 31 March 2024. The review followed Preferred Reporting Items for Systematic Reviews Meta-Analyses. Two authors independently screened articles by title, abstract full text. Newcastle–Ottawa Scale used assess bias included articles. Fixed- or random-effects meta-analysis when at least two reported ORs relative risks, 95% CIs. Heterogeneity assessed using I2 statistic. registered PROSPERO (ID: CRD42023459895 ). Results identified 947 through database searches, which met our inclusion criteria. revealed infection. Interaction infected animals (OR=5.61, CI 2.83, 11.13), HIV infection (OR=4.46, 3.27, 6.08), other sexually transmitted infections (OR=1.76, 1.42, 2.19), unprotected sexual activities (OR=1.53, 1.13, 2.07), contact an person (OR=2.39, 1.87, 3.05), identification men who have sex (OR=2.18, 1.88, 2.51) having multiple partners (OR=1.61, 1.24, 2.09) were increased risk. Conversely, smallpox vaccination significantly reduced (OR=0.24, 0.11, 0.55). Conclusion Identification provides insights strategic planning, enabling targeted interventions high-risk groups optimising resource allocation strengthen control efforts.

Language: Английский

Citations

1
Chemsex among men who have sex with men during the Mpox health crisis in Brazil: A nationwide web survey DOI Creative Commons
Guilherme Reis de Santana Santos, Caí­que Jordan Nunes Ribeiro, Shirley Verônica Melo Almeida Lima

et al.

Public Health Nursing, Journal Year: 2024, Volume and Issue: 41(3), P. 589 - 601

Published: March 25, 2024

Abstract Objective To understand the factors associated with practice of chemsex among MSM in Brazil, especially during Mpox health crisis, and to design effective prevention intervention strategies specifically for this population. Design A cross‐sectional analytical study using an electronic survey, conducted from September December 2022, peak outbreak Brazil. Sample total 1452 aged 18 older. Measurements Data were collected via REDCap platform through a survey 46 questions. These addressed demographic data, sexual affiliations, practices, experiences Mpox, healthcare service usage, stigma or fear related Mpox. Results The prevalence was 19.42% ( n = 282). Multivariate Poisson modeling indicated high incidence those diagnosed involved high‐risk behaviors. six times higher (95% CI: 4.73–9.10). who engage bugchasing had twice that main outcome 1.31–3.16). Conclusion There is significant need targeted interventions given outbreak. This highlights strong relationships between chemsex, various behaviors, underscoring importance public initiatives.

Language: Английский

Citations

3
Risk Factors of Human Mpox (Monkeypox) Infection: A Systematic Review and Meta-Analysis DOI Creative Commons
Chigozie Louisa J. Ugwu, Nicola Luigi Bragazzi, Jian Wu

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 20, 2024

Abstract Background Mpox (formerly Monkeypox) virus has affected the lives of thousands individuals both in endemic and non-endemic countries. Before May 2022 outbreak, infections were sporadically Central Western Africa, still research into been limited lacking epidemiological data. Thus, identification potential risk factors to better understand who is at being infected critical for future prevention control. Objective To synthesize comprehensive evidence on associated with human transmission countries from inception March 31, 2024. Methods The Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines followed conducting systematic review. Electronic databases searched. Two reviewers sifted articles that included review: firstly, by title abstract, secondly, full text. We used Newcastle-Ottawa Scale (NOS) assess bias articles. Fixed or random effects meta-analysis conducted when least two studies reported odds ratios (OR), relative risks (RR), 95% confidence intervals (CI). Heterogeneity was assessed using I 2 statistic sensitivity analysis also done. study protocol registered under PROSPERO ID: CRD42023459895 . Results 947 identified database search 31 eligible be findings showed interaction animals ( OR = 5.61, CI 2.83, 11.13), HIV 4.46, 3.27, 6.08), other STIs 1.76, 1.42, 2.91), sexual contact/activities (OR 1.53, 1.13, 4.82), contact an person 2.39, 95%CI 1.87, 3.05), as men have sex (MSM) 2.18, 1.88, 2.51), having multiple partners 1.61, 1.24, 2.09), increased contracting Mpox. However, patients vaccinated against smallpox had a lower infection 0.24, 0.11, 0.55). Conclusion This first Our demonstrated certain Mpox, whereas vaccination protective role could facilitate strategic public health planning targeted intervention. Key messages this article What already known topic (monkeypox) zoonotic infectious disease notable global importance due recent outbreaks Prior travel areas animals, close lesions, particularly among household members. adds add body efforts assist intervention revealed strong correlation between infection, HVI, STIs, physical contacts, MSM. While may factor lesions STIs. How might affect research, practice policy results review provide support policymakers based factors.

Language: Английский

Citations

0