Inflammaging: The ground for sarcopenia?

Experimental Gerontology, Journal Year: 2022, Volume and Issue: 168, P. 111931 - 111931

Published: Aug. 17, 2022

Language: Английский

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Association of gut microbiome and primary liver cancer: A two‐sample Mendelian randomization and case–control study

Liver International, Journal Year: 2022, Volume and Issue: 43(1), P. 221 - 233

Published: Oct. 27, 2022

Observational epidemiology studies suggested a relationship between the gut microbiome and primary liver cancer. However, causal remains unclear because of confounding factors reverse causality. We aimed to explore role in development cancer, including hepatocellular carcinoma (HCC) intrahepatic cholangiocarcinoma (ICC).

Language: Английский

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The Effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People

Nutrients, Journal Year: 2022, Volume and Issue: 14(16), P. 3384 - 3384

Published: Aug. 18, 2022

Obesity is a problem of modern health care that causes the occurrence many concomitant diseases: arterial hypertension, diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. New strategies for treatment prevention obesity are being developed based on using probiotics modulation gut microbiota. Our study aimed to evaluate bacterial composition obese patients before after two weeks lactic acid bacteria (

Language: Английский

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Calorie restriction improves metabolic state independently of gut microbiome composition: a randomized dietary intervention trial

Genome Medicine, Journal Year: 2022, Volume and Issue: 14(1)

Published: March 14, 2022

The gut microbiota has been suggested to play a significant role in the development of overweight and obesity. However, effects calorie restriction on obese adults, especially over longer durations, are largely unexplored.Here, we longitudinally analyzed intermittent (ICR) operationalized as 5:2 diet versus continuous (CCR) fecal 147 or adults 50-week parallel-arm randomized controlled trial, HELENA Trial. primary outcome trial was differential ICR CCR gene expression subcutaneous adipose tissue. Changes microbiome, which focus this publication, were defined exploratory endpoint trial. comprised 12-week intervention period, maintenance final follow-up period 26 weeks.Both diets resulted ~5% weight loss. except for Lactobacillales being enriched after ICR, post-intervention microbiome composition did not significantly differ between groups. Overall loss associated with metabolic improvements, but changes microbiome. Nonetheless, abundance Dorea genus at baseline moderately predictive subsequent (AUROC 0.74 distinguishing highest lowest quartiles). Despite lack consistent composition, study group-independent co-variation bacterial families biomarkers, anthropometric measures, dietary detectable. Our analysis particular revealed associations insulin sensitivity (HOMA-IR) Akkermansiaceae, Christensenellaceae, Tanerellaceae. It also suggests possibility beneficial modulation latter two intestinal taxa by high vegetables fiber, low processed meat.Overall, our results suggest that remains stable highly individual-specific under restriction.The including present component, prospectively registered ClinicalTrials.gov NCT02449148 May 20, 2015.

Language: Английский

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Long-term human spaceflight and inflammaging: Does it promote aging?

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 87, P. 101909 - 101909

Published: March 12, 2023

Spaceflight and its associated stressors, such as microgravity, radiation exposure, confinement, circadian derailment disruptive workloads represent an unprecedented type of exposome that is entirely novel from evolutionary stand point. Within this perspective, we aimed to review the effects prolonged spaceflight on immune-neuroendocrine systems, brain brain-gut axis, cardiovascular system musculoskeletal apparatus, highlighting in particular similarities with accelerated aging process. In particular, spaceflight-induced muscle atrophy/sarcopenia bone loss, vascular metabolic changes, hyper hypo reaction innate adaptive immune appear be modifications shared Most these are mediated by molecular events include oxidative mitochondrial stress, autophagy, DNA damage repair telomere length alteration, among others, which directly or indirectly converge activation inflammatory response. According inflammaging theory aging, response could a driver acceleration normal, physiological rate it likely all systemic turn lead increase sort vicious cycle. The most updated countermeasures fight will also discussed light their possible application not only for astronauts' benefit, but older adults ground.

Language: Английский

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Aerial transport of bacteria by dust plumes in the Eastern Mediterranean revealed by complementary rRNA/rRNA-gene sequencing

Communications Earth & Environment, Journal Year: 2023, Volume and Issue: 4(1)

Published: Feb. 6, 2023

Abstract Processes influencing the transport of airborne bacterial communities in atmosphere are poorly understood. Here, we report comprehensive and quantitative evidence key factors by dust plumes Eastern Mediterranean. We extracted DNA RNA from size-resolved aerosols sampled air masses different origins, followed qPCR high-throughput amplicon sequencing 16 S ribosomal gene transcripts. find that community composition varied with mass origin particle size. Bacterial abundance, alpha diversity species richness were higher terrestrially influenced than marine-influenced coarse fraction (3.0 to 10.0 µm) fine (0.49 1.5 µm). This suggests bacteria mainly associated particles or transported as cell aggregates. High abundances rRNA human, animal plant pathogen taxa indicate potential ecological impacts atmospheric transport.

Language: Английский

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Gut microbiome and frailty: insight from genetic correlation and mendelian randomization

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(2)

Published: Nov. 21, 2023

Observational studies have shown that the gut microbiome is associated with frailty. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess genetic correlation and relationships between genetically predicted frailty using linkage disequilibrium score regression (LDSC) Mendelian Randomization (MR). Summary statistics for were obtained from a genome-wide association (GWAS) meta-analysis of MiBioGen consortium (N = 18,340). GWAS meta-analysis, including UK Biobank TwinGene 175,226). We used LDSC MR analyses estimate causality Our findings indicate suggestive Christensenellaceae R-7 Moreover, we found evidence twelve genus-level microbes on at least two methods. There was no horizontal pleiotropy or heterogeneity in analysis. This provides potential several More population-based observational animal experiments are required clarify underlying mechanisms.

Language: Английский

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Probiotics Mediate Intestinal Microbiome and Microbiota-Derived Metabolites Regulating the Growth and Immunity of Rainbow Trout (Oncorhynchus mykiss)

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(2)

Published: March 14, 2023

Emerging evidence confirms using probiotics in promoting growth and immunity of farmed fish. However, the molecular mechanisms underlying host-microbiome interactions mediated by are not fully understood. In this study, we used rainbow trout (Oncorhynchus mykiss) as a model to investigate internal influenced two probiotic bacteria, Bacillus velezensis Lactobacillus sakei. We carried out experiments, including intestinal histology, serum physiology, transcriptome combined microbiome metabolite profiling. Our results showed that both had positive effect on growth, immunity, enzyme activity, gut microbiome, resistance Aeromonas salmonicida trout. Moreover, microbial structure was reshaped with increased relative abundance potential beneficial such Ruminococcus, Lachnospiraceae ucg-004, Leptotrichia, coagulans, Porphyromonadaceae, Anaerococcus, Photobacterium B. group Paenibacillaceae Eubacterium hallii L. sakei group. Metabolomic profiling analysis revealed upregulated metabolites biomarkers, i.e., sucrose l-malic acid group, N-acetyl-l-phenylalanine, N-acetylneuraminic acid, hydroxyproline Additionally, multiomics illustrated significant correlations between microflora, metabolites, gene expression associated growth. This study highlights role effectors activity shows different can have species-specific physiological regulation host. These findings contribute better understanding complex may implications for use aquaculture. IMPORTANCE Probiotics kinds live microbes impart effects Recent studies proven when given supplementation probiotics, fish improved disease prevention promotion. metabolic functions regarding their involvement regulating phenotypes, nutrient utilization, immune response yet well understood aquaculture field. Given active microbiota performance, conducted experiments The microbiome- microbiota-derived fish, participated contributed functional host health species.

Language: Английский

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Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity

Cell Reports Medicine, Journal Year: 2023, Volume and Issue: 4(12), P. 101341 - 101341

Published: Dec. 1, 2023

The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease (NAFLD). Histidine is a key energy source for microbiota, scavenging it from host. Its role in NAFLD poorly known. Plasma metabolomics, transcriptomics, and fecal metagenomics were performed three human cohorts coupled with hepatocyte, rodent, Drosophila models. Machine learning analyses identified plasma histidine as being strongly inversely associated steatosis linked hepatic transcriptomic signature involved insulin signaling, inflammation, trace amine-associated receptor 1. Circulating was Proteobacteria positively bacteria lacking utilization (Hut) system. supplementation improved different animal models (diet-induced mouse flies, ob/ob mouse, ovariectomized rats) reduced de novo lipogenesis. Fecal transplantation (FMT) low-histidine donors mono-colonization germ-free flies Enterobacter cloacae increased triglyceride accumulation content. interplay among catabolism, opens therapeutic opportunities.

Language: Английский

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Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: April 29, 2024

Microbial-based therapeutics in clinical practice are of considerable interest, and a recent study demonstrated fecal microbial transplantation (FMT) followed by dietary fiber supplements improved glucose homeostasis. Previous evidence suggests that donor recipient compatibility FMT protocol key determinants, but little is known about the involvement specific factors. Using data from our randomized placebo-control phase 2 trial adults with obesity metabolic syndrome, we grouped participants received one 4 donors either supplement into HOMA-IR responders (n = 21) non-responders 8). We further assessed plasma bile acids using targeted metabolomics performed subgroup analyzes to evaluate effects parameters gastrointestinal factors on microbiota engraftment homeostatic model assessment insulin resistance (HOMA2-IR) response. The baseline composition at genus level recipients could predict improvements HOMA2-IR week 6 (ROC-AUC 0.70). Prevotella was identified as an important predictor, having significantly lower relative abundance than (p .02). In addition, displayed highly individualized degree donors. Compared non-responders, had increased bacterial richness (Chao1) after more consistent donor-specific bacteria ASVs (amplicon sequence variants) such Faecalibacillus intestinalis (ASV44), Roseburia spp. (ASV103), Christensenellaceae (ASV140) < .05). Microbiota strongly associated recipients' including initial gut diversity, nutrient intakes, inflammatory markers, acid derivative levels. This therapy higher rate microbes, which were correlated sensitivity improvements. Further, related determinants for responsiveness supplementation. findings provide basis development precision treatment syndrome.

Language: Английский

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