Inulin-enriched Megamonas funiformis ameliorates metabolic dysfunction-associated fatty liver disease by producing propionic acid DOI Creative Commons
Xinyue Yang,

Meihong Zhang,

Yan Liu

et al.

npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)

Published: Nov. 4, 2023

Abstract Accumulated evidence supports the beneficial role of inulin in alleviating metabolic dysfunction-associated fatty liver disease (MAFLD) by modulating gut microbiota. However, underlying mechanisms are not fully understood. Here we used high-fat diet (HFD)-induced laying hen model MAFLD to investigate effect on ameliorating and found that inulin-enriched Megamonas genus was inversely correlated with hepatic steatosis-related parameters. Oral administration a newly isolated commensal bacterium culturomics, M. funiformis CML154, HFD-fed hens mice ameliorated MAFLD, changed gene expression profiles, increased intestinal propionate concentration. Further demonstrated anti-MAFLD CML154 is attributed propionate-mediated activation APN - AMPK PPARα signaling pathway, thereby inhibiting acid de novo synthesis promoting β-oxidation. These findings establish causal relationships among inulin, , suggest probiotic candidate for preventative or therapeutic intervention MAFLD.

Language: Английский

Pathogenic effects of Desulfovibrio in the gut on fatty liver in diet-induced obese mice and children with obesity DOI
Yu‐Cheng Lin, Hsueh-Fang Lin, Chi-Chien Wu

et al.

Journal of Gastroenterology, Journal Year: 2022, Volume and Issue: 57(11), P. 913 - 925

Published: Aug. 17, 2022

Language: Английский

Citations

46
Lactobacillus sakei MJM60958 as a Potential Probiotic Alleviated Non-Alcoholic Fatty Liver Disease in Mice Fed a High-Fat Diet by Modulating Lipid Metabolism, Inflammation, and Gut Microbiota DOI Open Access
Huong Thi Nguyen, Mingkun Gu,

Pia Werlinger

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13436 - 13436

Published: Nov. 3, 2022

Non-alcoholic fatty liver disease (NAFLD) is a common with rapidly increasing number of cases worldwide. This study aimed to evaluate the effects Lactobacillus sakei MJM60958 (MJM60958) on NAFLD in vitro and vivo. In tests, significantly inhibited lipid accumulation by 46.79% HepG2 cells stimulated oleic acid cholesterol (OA-C). Moreover, showed safe probiotic characteristics vitro. animal study, administration high-fat diet-induced mouse model reduced body weight weight, controlled aspartate aminotransferase (ALT), transaminase (AST), triglyceride (TG), urea nitrogen (BUN), uric (UA) levels blood, which are features NAFLD. Further, treatment also steatosis scores tissues, serum leptin interleukin, increased adiponectin content. resulted decreased expression some genes proteins related accumulation, such as synthase (FAS), acetyl-CoA carboxylase (ACC), sterol regulatory element-binding protein 1 (SREBP-1), upregulated oxidation peroxisome proliferator-activated receptor alpha (PPARα) carnitine palmitoyltransferase 1a (CPT1A). Administration relative abundance specific microbial taxa Verrucomicrobia, abundant non-NAFLD mice, Firmicutes, major group mice. affected modulation gut microbiota altered strain profile short-chain acids (SCFAs) production cecum lactic enhanced acetic production. Overall, potential that can prevent treat

Language: Английский

Citations

41
Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress DOI Creative Commons
Ling Ye,

Yuanlong Hou,

Wanyu Hu

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 3, 2023

Chronic stress is a known risk factor for breast cancer, yet the underlying mechanisms are unclear. This study explores potential involvement of microbial and metabolic signals in chronic stress-promoted cancer progression, revealing that reduced abundances Blautia its metabolite acetate may contribute to this process. Treatment with increases antitumor responses CD8

Language: Английский

Citations

34
Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota DOI
Yanan Li, Junping Zheng, Yao Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 242, P. 124789 - 124789

Published: May 9, 2023

Language: Английский

Citations

32
Inulin-enriched Megamonas funiformis ameliorates metabolic dysfunction-associated fatty liver disease by producing propionic acid DOI Creative Commons
Xinyue Yang,

Meihong Zhang,

Yan Liu

et al.

npj Biofilms and Microbiomes, Journal Year: 2023, Volume and Issue: 9(1)

Published: Nov. 4, 2023

Abstract Accumulated evidence supports the beneficial role of inulin in alleviating metabolic dysfunction-associated fatty liver disease (MAFLD) by modulating gut microbiota. However, underlying mechanisms are not fully understood. Here we used high-fat diet (HFD)-induced laying hen model MAFLD to investigate effect on ameliorating and found that inulin-enriched Megamonas genus was inversely correlated with hepatic steatosis-related parameters. Oral administration a newly isolated commensal bacterium culturomics, M. funiformis CML154, HFD-fed hens mice ameliorated MAFLD, changed gene expression profiles, increased intestinal propionate concentration. Further demonstrated anti-MAFLD CML154 is attributed propionate-mediated activation APN - AMPK PPARα signaling pathway, thereby inhibiting acid de novo synthesis promoting β-oxidation. These findings establish causal relationships among inulin, , suggest probiotic candidate for preventative or therapeutic intervention MAFLD.

Language: Английский

Citations

29