Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Language: Английский

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Integrating multi-omics data to reveal the host-microbiota interactome in inflammatory bowel disease

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 10, 2025

Numerous studies have accelerated the knowledge expansion on role of gut microbiota in inflammatory bowel disease (IBD). However, precise mechanisms behind host-microbe cross-talk remain largely undefined, due to complexity human intestinal ecosystem and multiple external factors. In this review, we introduce interactome concept systematically summarize how dysbiosis is involved IBD pathogenesis terms microbial composition, functionality, genomic structure, transcriptional activity, downstream proteins metabolites. Meanwhile, review also aims present an updated overview relevant mechanisms, high-throughput multi-omics methodologies, different types cohort resources, computational methods used understand host-microbiota interactions context IBD. Finally, discuss challenges pertaining integration data order reveal offer insights into future research directions.

Language: Английский

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Reducing diagnostic delays of extraintestinal manifestations in inflammatory bowel disease: a comparative study of a multidisciplinary outpatient clinic versus conventional referral specialists

Therapeutic Advances in Gastroenterology, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 1, 2025

Managing extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD) patients remains challenging due to considerable heterogeneity diagnostic criteria and the lack of a standardised definition validated pathways. Delays recognising treating EIMs can lead significant progression. Therefore, early detection treatment are crucial. We aimed assess effectiveness dedicated immune-mediated diseases (IMIDs) clinic reducing EIM delays improving patients' outcomes. A single-centre observational study was conducted, including IBD presenting with red flags. compared delay between who attended multidisciplinary IMID outpatient (IMID-G) those individual referral specialists representing standard group (SOC-G). further evaluated impact timing on 18-month clinical outcomes, therapeutic changes, steroid immunosuppressant use biological therapy switch/swap. enrolled 238 patients, 127 IMID-G 111 SOC-G. The average time diagnosis 2.48 ± 1.8 5.36 2.3 months for SOC-Gs (Δ = 2.88 months, p 0.005). majority received peripheral arthritis (IMID-G 37.5%; SOC-G 33.7%) spondyloarthropathy 32.1%; 33.7%). No difference observed rates two groups (88.2% vs 92.8% SOC-G, 0.27). Regarding reported mean first change driven by specialist 2.96 6.09 2.5 showing (p 0.007). had higher frequency switching/swapping adding immunosuppressive than 0.008 0.04, respectively). Survival curves revealed reduction (log-rank test, < 0.001). Attending enhance process thereby allowing interventions avoid

Language: Английский

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Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 18, 2025

ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized

Language: Английский

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Bile acids, gut microbiota, and therapeutic insights in hepatocellular carcinoma

Cancer Biology and Medicine, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 19

Published: Dec. 23, 2023

Hepatocellular carcinoma (HCC) is a prevalent and aggressive liver malignancy. The interplay between bile acids (BAs) the gut microbiota has emerged as critical factor in HCC development progression. Under normal conditions, BA metabolism tightly regulated through bidirectional microorganisms BAs. plays role metabolism, BAs are endogenous signaling molecules that help maintain intestinal homeostasis. Of note, dysbiotic changes during pathogenesis cancer can disrupt homeostasis, thereby leading to inflammation fibrosis, ultimately contributing development. Therefore, understanding intricate crucial for elucidating mechanisms underlying hepatocarcinogenesis. In this review, we comprehensively explore roles functions of with focus on interactions HCC. Additionally, therapeutic strategies targeting discussed, including use agonists/antagonists, probiotic/prebiotic dietary interventions, fecal transplantation, engineered bacteria. summary, complex BA-microbiota crosstalk provide valuable insights into facilitate innovative approaches

Language: Английский

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Gigantol ameliorates DSS-induced colitis via suppressing β2 integrin mediated adhesion and chemotaxis of macrophage

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 118123 - 118123

Published: March 28, 2024

Language: Английский

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Ophthalmological Manifestations in Inflammatory Bowel Diseases: Keep an Eye on It

Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 142 - 142

Published: Jan. 12, 2024

Background and aims: Inflammatory bowel diseases (IBD) are multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. However, a broad spectrum of extraintestinal manifestations (EIMs) is associated with IBD, several organs systems, such as skin, musculoskeletal hepatobiliary and, not least, eye. Approximately 10% IBD patients can develop ocular EIMs (O-EIMs) higher prevalence in Crohn’s disease (CD). Eye-redness, photophobia, pain, blurred vision common symptoms, wide rate severity clinical impact on quality life. This narrative review aims to summarize prevalence, pathogenesis, current evidence-based management O-EIMs, underlying importance holistic approach specialties collaboration for prompt diagnosis treatment. Methods: PubMed was searched up December 2023 identify relevant studies investigating epidemiology, treatment O-EIMs patients. Results: The mechanisms partially unknown, encompassing immune dysregulation, shared antigens between eye gut, genetic predisposition, systemic inflammation driven by high levels interleukins cytokines complexity O-EIMs’ pathogenesis reflects these conditions, varying from topical steroids immunomodulatory molecules biologic therapy, anti-tumor necrosis factor (TNF)-alpha. A multidisciplinary backbone O-EIMs.

Language: Английский

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Current Knowledge of Enterococcal Endocarditis: A Disease Lurking in Plain Sight of Health Providers

Pathogens, Journal Year: 2024, Volume and Issue: 13(3), P. 235 - 235

Published: March 7, 2024

Enterococcus faecalis is a bacterial pathogen that can cause opportunistic infections. Studies indicate initial biofilm formation plays crucial regulatory role in these infections, as well colonising and maintaining the gastrointestinal tract commensal member of microbiome most land animals. It has long been thought vegetation endocarditis resulting from attachment to endocardial endothelium requires some pre-existing tissue damage, animal models experimental endocarditis, mechanical valve damage typically induced by cardiac catheterisation preceding infection. This section reviews historical contemporary model studies demonstrate ability E. colonise undamaged endovascular endothelial surface directly produce robust microcolony biofilms encapsulated within bacterially derived extracellular matrix. report both previous current demonstrating resilient capacity The article also considers morphological similarities when develop on different host sites, such colonises epithelium common vertebrate microbiome, lurking plain sight transmitting systemic These phenotypes may enable organism survive an unrecognised infection asymptomatic subjects, providing infectious resource for subsequent clinical process endocarditis.

Language: Английский

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Exploring the Role of Gut Microbiota in Patients with Alopecia Areata

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4256 - 4256

Published: April 11, 2024

Imbalances in gut microbiota reportedly contribute to the development of autoimmune diseases, but association between etiopathogenesis alopecia areata (AA) and microbial dysbiosis remains unclear. This cross-sectional study was conducted identify compare composition microbiome patients affected by AA those a healthy control (HC) group, investigate possible bacterial biomarkers for disease. Fecal samples were collected from 19 20 HCs analyze relationship with fecal bacteria. The three major genera constituting Bacteroides, Blautia, Faecalibacterium. alpha diversity group not statistically significant different that HC group. However, community significantly according Jensen–Shannon dissimilarities. In AA, we found an enriched presence Blautia Eubacterium_g5 compared (p < 0.05), whereas Bacteroides less prevalent 0.05). distinct Our findings suggest involvement as-yet-undefined pathogenesis AA.

Language: Английский

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Development of Akkermansia Muciniphila Membrane‐Coated Mesoporous Silica Nanoparticles with a Cerium Oxide Core for Inflammatory Bowel Disease Treatment

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Abstract While convenient for patient compliance, the efficacy of oral treatments inflammatory bowel disease (IBD) is often compromised by dynamic and harsh chemical environment gastrointestinal tract, presenting challenges effective therapeutic management. The pathological complexity IBD frequently involves multiple factors such as oxidative stress, immune dysregulation, gut microbiome abnormality, inadequate drug bioavailability, among others. To address these challenges, this project develops an nanomedicine platform based on mesoporous silica nanoparticles with a cerium oxide core, further coated outer membrane (OM) derived from Akkermansia muciniphila ( Akk ), beneficial bacteria naturally present in human gut. This novel nanocomplex, termed “OM‐CeMeso,” evaluated its enhanced stability, reactive oxygen species (ROS) scavenging capacity, ability to restore microbiota homeostasis. demonstrates that silica‐based nanomaterials’ acid‐resistant yet base‐degradable properties significantly improved stability murine model. incorporation (CeO 2 NPs) added benefits enhancing ROS scavenging. Notably, Akk‐ OM coat also increases diversity abundance microbiota. These complementary integrated functions lead significant symptom alleviation models while avoiding any unwanted toxicity.

Language: Английский

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